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  1. 1801
    “…We recently described an oncolytic vaccinia virus (VV), VVLΔTKΔN1L, which has potent antitumor activity, and a regime to enhance intravenous delivery of VV by pharmacological inhibition of pharmacological inhibition of PI3 Kinase δ (PI3Kδ) to prevent virus uptake by macrophages. …”
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    A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer
  2. 1802
    “…RESULTS: We found that the best ray tracing combination (Anterion-OKULIX) resulted in an arithmetic prediction error statistically significantly lower than that achieved with the best formula calculation (Barret True-K no-history) (−0.13 D and −0.32 D, respectively, adjusted p = 0.01), while the Barret TK NH had the lowest SD. The absolute prediction error was 0.26 D and 0.35 D for Anterion-OKULIX and Barret TK NH, respectively, but this was not statistically significantly different. …”
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    Refractive Precision of Ray Tracing IOL Calculations Based on OCT Data versus Traditional IOL Calculation Formulas Based on Reflectometry in Patients with a History of Laser Vision Correction for Myopia
  3. 1803
    “…Based on a comparative genome analysis, we found that the isolated Enterococcus faecium TK-P5D clustered with a well-defined probiotic strain, while E. faecalis TK-P4B clustered with a pathogenic strain. …”
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    Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks
  4. 1804
    “…Total N (TN), total P (TP), total K (TK), Mg and Fe contents in leaf were positively affected by PSBs while showed a significant relationship with strain and dilution ratio. …”
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    Isolation and screening of multifunctional phosphate solubilizing bacteria and its growth-promoting effect on Chinese fir seedlings
  5. 1805
    “…The Mer tyrosine kinase (MerTK) deficiency or the knockout of chemokine receptor C–C motif chemokine receptor 2 (CCR2) reversed these protective effects of MSCs or DMSCs. …”
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    Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine
  6. 1806
    “…Gene expression analysis assessing the levels of the 33 proteins showed that 5 (YBX3, EIF4EBP2, DKK1, GNPNAT1 and TK1) had higher expression levels in the radiosensitive cells compared to their radioresistant derivatives; 3 of these proteins (DKK1, GNPNAT1 and TK1) underwent in-lab and initial clinical validation. …”
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    A Novel Approach for the Discovery of Biomarkers of Radiotherapy Response in Breast Cancer
  7. 1807
    “…Five mice underwent human skeletal muscle-derived stem/progenitor cell (huSkMDS/PC EF1-HSV-TK) intracardial transplantation after induction of myocardial infarction (MI). …”
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    Molecular imaging of myogenic stem/progenitor cells with [(18)F]-FHBG PET/CT system in SCID mice model of post-infarction heart
  8. 1808
    “…Compared with si-NC group, si-lncRNA IGF2-AS group had increased proliferation ability, decreased pyroptosis, decreased HMGA1, RRM2, TK1, and TYMS expressions. lncRNA IGF2-AS played a regulatory role by binding HMGA1. …”
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    lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients
  9. 1809
    “…Using this method, we identified both a new DNA endonuclease activity for a previously described RNA endonuclease (Nob1) and a novel AP lyase DNA repair enzyme family (termed 'TK0353') that is found only in a small subset of Thermococcales. …”
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    Capillary Electrophoresis-Based Functional Genomics Screening to Discover Novel Archaeal DNA Modifying Enzymes
  10. 1810
    “…Perioperative dynamics of interleukin (IL)‐6, soluble tyrosine‐protein kinase MER (sMerTK), soluble CD163 (sCD163), and cytokeratin (CK) 18 were assessed to reflect pathophysiological processes. …”
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    Immunological Aspects of AXL/GAS‐6 in the Context of Human Liver Regeneration
  11. 1811
    “…Methods: We investigated the differential expression of 15 efferocytosis-related molecules (Axl, Tyro3, MerTK, CX3CL1, Tim-4, BAI1, Stab2, Gas6, IDO1, Rac1, MFGE8, ICAM-1, CD47, CD31, and PD-L1) and other 12 common immune checkpoint-related molecules in tumor and normal tissues, the correlation between their expression and various clinicopathological features in 16 types of cancers using publicly available pancancer datasets in The Cancer Genome Atlas. …”
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    The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity
  12. 1812
    “…PATIENTS AND METHODS: In this single-arm, open-label Phase 2 trial, patients with mTNBC were treated with ADV/HSV-tk [5 × 10(11) virus particles (vp)] intratumoral injection, followed by SBRT to the injected tumor site, then pembrolizumab (200 mg, every 3 weeks). …”
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    A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
  13. 1813
    por Horie, Yasuyuki
    Publicado 2009
    “…Of the four extensive chapters in this volume, the first two describe the reactive behavior of condensed phase explosives, - Condensed-Phase Explosives: Shock Initiation and Detonation Phenomena (SA Sheffield and R Engelke) - First Principles Molecular Simulations of Energetic Materials at High-Pressures (F Zhang, S Alavi, and TK Woo), and the remaining two discuss the inert, mechanical response of solid materials. - Combined Compression and Shear Plane Waves (ZP Tang and JB Aidun), and - Dynamic Fragmentation of Solids (D Grady). …”
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    Shock wave science and technology reference library
  14. 1814
    “…A major restructuring of its core has resulted in an improvement in its modularity, with some immediate advantages: its tracking core, which is one of the fastest available for this kind of simulations, is now interfaced toward three different scripting languages to further expand its simulation capabilities: Tcl/Tk, Octave, and Python. These three languages provide access to a vast and diverse library of scientific tools, mechanisms for parallel computing, and access to Java interfaces for control systems. …”
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    Evolution of the Tracking Code PLACET
  15. 1815
    por Kumar, Lokesh, E. Futschik, Matthias
    Publicado 2007
    “…The additional package Mfuzzgui provides a convenient TclTk based graphical user interface. AVAILABILITY: The R package Mfuzz and Mfuzzgui are available at http://itb1.biologie.hu-berlin.de/~futschik/software/R/Mfuzz/index.html. …”
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    Mfuzz: A software package for soft clustering of microarray data
  16. 1816
    “…Gromita is a cross-platform, perl/tcl-tk based, interactive front end designed to break the command line barrier and introduce a new user-friendly environment to run molecular dynamics simulations through Gromacs. …”
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    Gromita: A Fully Integrated Graphical User Interface to Gromacs 4
  17. 1817
    “…SeqCalc is a package of offline program, developed using Perl and TCL/Tk scripts that serve ten different applications. …”
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    SeqCalc: A portable bioinformatics software for sequence analysis
  18. 1818
    “…We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect.…”
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    Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
  19. 1819
    “…Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. …”
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    The Gas6/TAM System and Multiple Sclerosis
  20. 1820
    por Hamilton, Chris
    Publicado 2008
    “…The paper then follows this with an analysis of how knowledge is treated in those same systems, focusing specifically on some of the challenges that arise when attempting to bring traditional knowledge (TK) under the rubric of the IPR system. Finally, it examines the allegation of biopiracy in greater depth, and reflects on how it critiques the way the bioeconomy and the IPR regime treat nature, culture, knowledge, and the relationship between them.…”
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    Intellectual property rights, the bioeconomy and the challenge of biopiracy
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