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154401por Marler, Jennifer D, Fujii, Craig A, Utley, David S, Tesfamariam, Lydia J, Galanko, Joseph A, Patrick, Heather“…Pivot includes 5 sequential stages (Explore, Build, Mobilize, Quit, and Secure), taking 14.5 to 18.5 weeks to complete. Data were collected via app and online questionnaires. …”
Publicado 2019
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154402por Amroze, Azraa, Field, Terry S, Fouayzi, Hassan, Sundaresan, Devi, Burns, Laura, Garber, Lawrence, Sadasivam, Rajani S, Mazor, Kathleen M, Gurwitz, Jerry H, Cutrona, Sarah L“…We encountered 2 main challenges: (1) Capturing a historical snapshot of EHR status (number of InBasket messages at time of alert delivery) required incorporation of data generated many months prior with longitudinal follow-up. (2) Accurately interpreting data elements required iterative work by a physician/data manager team taking action within the EHR and then examining audit logs to identify corresponding documentation. …”
Publicado 2019
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154403por Büyükkaramikli, Nasuh C., de Groot, Saskia, Riemsma, Rob, Fayter, Debra, Armstrong, Nigel, Portegijs, Piet, Duffy, Steven, Kleijnen, Jos, Al, Maiwenn J.“…After two appraisal committee meetings and a revised base case submitted by the company (including a second enhanced patient access scheme discount), the committee concluded that taking into account the uncertainties in the calculation of the cost effectiveness, there were plausible cost-effectiveness estimates broadly in the range that could be considered as a cost-effective use of National Health Service resources. …”
Publicado 2018
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154404por Manne-Goehler, Jennifer, Geldsetzer, Pascal, Agoudavi, Kokou, Andall-Brereton, Glennis, Aryal, Krishna K., Bicaba, Brice Wilfried, Bovet, Pascal, Brian, Garry, Dorobantu, Maria, Gathecha, Gladwell, Singh Gurung, Mongal, Guwatudde, David, Msaidie, Mohamed, Houehanou, Corine, Houinato, Dismand, Jorgensen, Jutta Mari Adelin, Kagaruki, Gibson B., Karki, Khem B., Labadarios, Demetre, Martins, Joao S., Mayige, Mary T., McClure, Roy Wong, Mwalim, Omar, Mwangi, Joseph Kibachio, Norov, Bolormaa, Quesnel-Crooks, Sarah, Silver, Bahendeka K., Sturua, Lela, Tsabedze, Lindiwe, Wesseh, Chea Stanford, Stokes, Andrew, Marcus, Maja, Ebert, Cara, Davies, Justine I., Vollmer, Sebastian, Atun, Rifat, Bärnighausen, Till W., Jaacks, Lindsay M.“…Diabetes was defined as fasting plasma glucose ≥ 7.0 mmol/l (126 mg/dl), random plasma glucose ≥ 11.1 mmol/l (200 mg/dl), HbA1c ≥ 6.5%, or reporting to be taking medication for diabetes. Stages of the care cascade were as follows: tested, diagnosed, lifestyle advice and/or medication given (“treated”), and controlled (HbA1c < 8.0% or equivalent). …”
Publicado 2019
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154405“…This study highlights the need for specific interventions by taking into consideration the contextual factors within the region and involving multi-sectoral collaboration between health authorities and related stakeholders (e.g., bureau of education, bureau of public works and infrastructure) to improve designs in planning and intervention strategies to succesfully eliminate malaria in Maluku and Papua. …”
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154406por Gupta-Wright, Ankur, Corbett, Elizabeth L., Wilson, Douglas, van Oosterhout, Joep J., Dheda, Keertan, Huerga, Helena, Peter, Jonny, Bonnet, Maryline, Alufandika-Moyo, Melanie, Grint, Daniel, Lawn, Stephen D., Fielding, Katherine“…Their median age was 36 years (IQR 30–43), 45.4% were female, median CD4 cell count at admission was 76 cells/μl (IQR 23–206), and 80.2% (210/262) of those who knew they were HIV-positive at hospital admission were taking antiretroviral therapy (ART). Two-month mortality was 30% (94/315), and mortality was associated with the following factors included in the score: age 55 years or older, male sex, being ART experienced, having severe anaemia (haemoglobin < 80 g/l), being unable to walk unaided, and having a positive urinary Determine TB LAM Ag test (Alere). …”
Publicado 2019
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154407por Castro, Juan Camilo, Valdés, Ivan, Gonzalez-García, Laura Natalia, Danies, Giovanna, Cañas, Silvia, Winck, Flavia Vischi, Ñústez, Carlos Eduardo, Restrepo, Silvia, Riaño-Pachón, Diego Mauricio“…METHOD: We defined interactions between pairs of genes (edges in the GRN) as the partial mutual information between these genes that takes into account time and possible lags in time from one gene in relation to another. …”
Publicado 2019
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154408por Pariyo, George W., Greenleaf, Abigail R., Gibson, Dustin G., Ali, Joseph, Selig, Hannah, Labrique, Alain B., Al Kibria, Gulam Muhammed, Khan, Iqbal Ansary, Masanja, Honorati, Flora, Meerjady Sabrina, Ahmed, Saifuddin, Hyder, Adnan A.“…Careful design can help ensure clarity of questions to minimize cognitive burden for respondents, many of whom may not have prior experience in taking automated surveys. Further research should explore possible differences and determinants of survey reliability between delivery modes and ideally compare both IVR and CATI surveys to in-person face-to-face interviews. …”
Publicado 2019
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154409por Schroeder, Emily B, Moore, Kelly, Manson, Spero M, Baldwin, Megan A, Goodrich, Glenn K, Malone, Allen S, Pieper, Lisa E, Xu, Stanley, Fort, Meredith M, Johnson, David, Son-Stone, Linda, Steiner, John F“…The messages include reminders of upcoming appointments at First Nations Community HealthSource, requests to reschedule recently missed appointments, monthly reminders to refill medications, and weekly motivational messages to encourage self-care, appointment keeping, and medication taking for hypertension. Individuals in the IVR-T arm could opt to nominate a care partner to also receive notices of upcoming and missed appointments. …”
Publicado 2019
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154410por Ramos, Elvira, Sanabria, Maria Concepcion, Montañez, M Carmen, de Miguel, M Paz, Calle, Alfonso L, Diaz, Jose Angel“…Only 10.4% were treated with somatostatin analogs. Taking into account both groups: Mean age was 64.75 (SD 12.03) in controls and 63.47 (SD 11.35) in cases. 75% of controls and 62% of cases were female.…”
Publicado 2019
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154411“…BACKGROUND Achieving diabetes control often takes months to years with intermittent clinic visits, infrequent changes in therapy and management by HbA1c levels. …”
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154412por Borgan, Faith, Laurikainen, Heikki, Veronese, Mattia, Marques, Tiago Reis, Haaparanta-Solin, Merja, Solin, Olof, Dahoun, Tarik, Rogdaki, Maria, Salokangas, Raimo KR, Karukivi, Max, Di Forti, Marta, Turkheimer, Federico, Hietala, Jarmo, Howes, Oliver“…Study 1 consisted of 18 volunteers, including 7 patients with affective or nonaffective psychoses taking antipsychotic medication and 11 matched controls; study 2, 40 volunteers, including 20 antipsychotic-naive or antipsychotic-free patients with schizophrenia or schizoaffective disorder and 20 matched controls. …”
Publicado 2019
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154413por Raman, Arjun S., Gehrig, Jeanette L., Venkatesh, Siddarth, Chang, Hao-Wei, Hibberd, Matthew C., Subramanian, Sathish, Kang, Gagandeep, Bessong, Pascal O., Lima, Aldo A.M., Kosek, Margaret N., Petri, William A., Rodionov, Dmitry A., Arzamasov, Aleksandr A., Leyn, Semen A., Osterman, Andrei L., Huq, Sayeeda, Mostafa, Ishita, Islam, Munirul, Mahfuz, Mustafa, Haque, Rashidul, Ahmed, Tahmeed, Barratt, Michael J., Gordon, Jeffrey I.“…This characteristic demands a different approach to describing the form of a microbiota—one that takes into consideration the abundances as well as the interactions between members. …”
Publicado 2019
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154414por Nash, Denis, Stief, Matthew, MacCrate, Caitlin, Mirzayi, Chloe, Patel, Viraj V, Hoover, Donald, Pantalone, David W, Golub, Sarit, Millett, Gregorio, D’Angelo, Alexa B, Westmoreland, Drew Anne, Grov, Christian“…Per eligibility criteria, all T5K participants reported having sex with >2 male partners in the 90 days before enrollment, self-reported not having been diagnosed with HIV, and were not actively taking PrEP. In addition, 79.39% (6968/8777) reported >2 insertive condomless anal sex (CAS) acts, 61.02% (5356/8777) reported >1 receptive CAS acts in the past 90 days. …”
Publicado 2019
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154415“…He was commenced on tocilizumab as a steroid sparing agent taking into consideration the severity and extent of his disease, the need for dual antiplatelet therapy and increased bleeding risk. …”
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154416por Sze, Jeeu Teck“…During his last clinic visit, he was taking prednisolone 2mg daily and the plan was to taper the dose down to zero over eight weeks. …”
Publicado 2019
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154417por Ashmeik, Walid, Joseph, Gabby B., Nevitt, Michael C., Lane, Nancy E., McCulloch, Charles E., Link, Thomas“…RESULTS/ANTICIPATED RESULTS: The average age of all study participants was 58.8 years (SD ± 8.6) with a higher proportion of men (59.4%), average body mass index (BMI) was 28.3 (SD ± 4.5), average SBP was 122.4 (SD ± 15.4) mmHg, average DBP was 75.5 (SD ± 9.6) mmHg and 469 (38.1%) study participants were taking at least one AHM. Higher baseline DBP was significantly associated with a faster increase in global T2 (0.22 [0.10,0.35], P < 0.001), global deep layer T2 (0.20 [0.03,0.36], P < 0.022) and global superficial layer T2 (0.39 [0.20,0.58], P < 0.001). …”
Publicado 2019
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154418por Scholtz, Arne W., Hahn, Ales, Stefflova, Bohdana, Medzhidieva, Daniela, Ryazantsev, Sergey V., Paschinin, Alexander, Kunelskaya, Natalia, Schumacher, Kai, Weisshaar, Gerhard“…CONCLUSION: The fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg was found to be not only non-inferior, but superior to betahistine 16 mg in the improvement of peripheral vestibular vertigo. Furthermore, taking into account a good and slightly favorable safety profile, the present study provides evidence that the fixed-combination preparation is a potent and even superior alternative to betahistine in the treatment of vertigo related to peripheral vestibular disorders. …”
Publicado 2019
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154419por Sathyendranath, Shubha, Brewin, Robert J.W., Brockmann, Carsten, Brotas, Vanda, Calton, Ben, Chuprin, Andrei, Cipollini, Paolo, Couto, André B., Dingle, James, Doerffer, Roland, Donlon, Craig, Dowell, Mark, Farman, Alex, Grant, Mike, Groom, Steve, Horseman, Andrew, Jackson, Thomas, Krasemann, Hajo, Lavender, Samantha, Martinez-Vicente, Victor, Mazeran, Constant, Mélin, Frédéric, Moore, Timothy S., Müller, Dagmar, Regner, Peter, Roy, Shovonlal, Steele, Chris J., Steinmetz, François, Swinton, John, Taberner, Malcolm, Thompson, Adam, Valente, André, Zühlke, Marco, Brando, Vittorio E., Feng, Hui, Feldman, Gene, Franz, Bryan A., Frouin, Robert, Gould, Richard W., Hooker, Stanford B., Kahru, Mati, Kratzer, Susanne, Mitchell, B. Greg, Muller-Karger, Frank E., Sosik, Heidi M., Voss, Kenneth J., Werdell, Jeremy, Platt, Trevor“…To ensure that the products meet, as well as possible, the requirements of the user community, marine-ecosystem modellers, and remote-sensing scientists were consulted at the outset on their immediate and longer-term requirements as well as on their expectations of ocean-colour data for use in climate research. Taking the user requirements into account, a series of objective criteria were established, against which available algorithms for processing ocean-colour data were evaluated and ranked. …”
Publicado 2019
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154420“…Neonates born to GBS colonized mothers who deliver via cesarean section will have a decreased incidence of sepsis compared to neonates born to GBS colonized mothers who deliver vaginally DISCUSSION/SIGNIFICANCE OF IMPACT: There have been no comprehensive studies to date that use the CLAP data to characterize the epidemiology of maternal GBS colonization and GBS disease and the burden of neonatal GBS disease in Latin America. Taking advantage of this unique database, this is the first region-wide study using systematically collected data. …”
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