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  1. 61
    por Caplin, Martyn E.
    Publicado 2021
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    Can the peptide receptor radionuclide therapy [(177)Lu]Lu-DOTA-TATE provide a net benefit for NET patients?
  2. 62
    “…SIMPLE SUMMARY: Neuroendocrine neoplasms have been usually described as infrequent tumors, but their incidence has been rising over time. [(177)Lu]Lu-DOTA-TATE (PRRT-Lu) was approved by the European Medicines Agency and by the Food and Drug Administration as the first radiopharmaceutical for peptide receptor radionuclide therapy in progressive gastroenteropancreatic NET. …”
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    Peptide Receptor Radionuclide Therapy with [(177)Lu]Lu-DOTA-TATE in Patients with Advanced GEP NENS: Present and Future Directions
  3. 63
    “…The purpose of this study was to compare the SSR-expression of differentiated gastroentero-pancreatic neuroendocrine tumours (GEP-NET) measured by [18F]SiTATE-PET/CT in patients with and without previous treatment with long-acting SSAs to evaluate if SSA treatment needs to be paused prior to [18F]SiTATE-PET/CT. …”
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    Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [(18)F]SiTATE
  4. 64
    “…SIMPLE SUMMARY: Peptide receptor radionuclide therapy (PRRT) with [(177)Lu]Lu-DOTA-TATE is used to treat gastroenteropancreatic neuroendocrine tumours (GEP-NET) by targeting somatostatin receptors (SSTRs) found on the cell surface. …”
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    Correlations between [(68)Ga]Ga-DOTA-TOC Uptake and Absorbed Dose from [(177)Lu]Lu-DOTA-TATE
  5. 65
    “…Longitudinal SPECT/CT images were acquired for (155)Tb- and (161)Tb- labelled crown-TATE in male NRG mice bearing AR42J tumours. The radiotracers, [(155)Tb]Tb-crown-TATE and [(161)Tb]Tb-crown-TATE, showed high tumour targeting (32.6 and 30.0 %ID/g, respectively) and minimal retention in non-target organs at 2.5 h post-administration. …”
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    Preclinical Evaluation of [(155/161)Tb]Tb-Crown-TATE—A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours
  6. 66
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    Comparison of 99mTc radiolabeled somatostatin antagonist with [(68) Ga]Ga-DOTA-TATE in a patient with advanced neuroendocrine tumor
  7. 67
    “…Patients received postoperative MRI and [(68)Ga]Ga-DOTA-TATE PET/CT and were followed regularly with MRI surveillance scans for detection of tumor recurrence/progression. …”
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    Postoperative [(68)Ga]Ga-DOTA-TATE PET/CT imaging is prognostic for progression-free survival in meningioma WHO grade 1
  8. 68
    “…BACKGROUND: The TATE trial was a multicentre pragmatic randomized controlled trial of supplementing primary care management (PCM)–consisting of a GP consultation followed by information and advice on exercises–with transcutaneous electrical nerve stimulation (TENS), to reduce pain intensity in patients with tennis elbow. …”
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    An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial
  9. 69
    “…We report the first use of (68)Gallium (Ga)-DOTA-TATE PET/CT to diagnose an ectopic TSH-secreting tumor located in the nasopharynx. …”
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    SAT-618 Ectopic Thyroid-Stimulating Hormone-Secreting Pituitary Adenoma of the Nasopharynx Diagnosed by (68)Ga-DOTA-TATE PET/CT
  10. 70
    “…In this study, we investigated the toxicity of a combined treatment with everolimus and [(177)Lu]Lu-DOTA-TATE in female Lewis rats. METHODS: Animals received 200 MBq of [(177)Lu]Lu-DOTA-TATE once and/or 5 mg/kg body weight everolimus or placebo weekly for 16 weeks and were divided into four groups (group 1, placebo; group 2, everolimus; group 3, placebo + [(177)Lu]Lu-DOTA-TATE; group 4, everolimus + [(177)Lu]Lu-DOTA-TATE). …”
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    Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [(177)Lu]Lu-DOTA-TATE in Lewis rats
  11. 71
    “…AIM: To evaluate the cost-effectiveness of [(177)Lu]Lu-DOTA-TATE versus relevant comparators for the treatment of neuroendocrine tumours located in the gastrointestinal tract (GI-NETs) and the pancreas (P-NETs). …”
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    Use of [(177)Lu]Lu-DOTA-TATE in the treatment of gastroenteropancreatic neuroendocrine tumours: Results of a UK cost-effectiveness modelling study
  12. 72
    “…METHOD: A total of 17 patients with neuroendocrine tumors who underwent clinical (68)Ga-DOTA-TATE PET/CT were involved in this study retrospectively. …”
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    The Impact of Total Variation Regularized Expectation Maximization Reconstruction on (68)Ga-DOTA-TATE PET/CT Images in Patients With Neuroendocrine Tumor
  13. 73
    “…This is the first evaluation of the association between TATE and the biologic behavior of MCTs. This study suggests that TATE investigation could be an important source of information for this tumor and for other neoplasms. …”
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    Preliminary Assessment of Tumor-Associated Tissue Eosinophilia (TATE) in Canine Mast Cell Tumors: Prevalence and Prognostic Relevance and Its Association with Neoangiogenesis
  14. 74
    “…METHODS: Patients with gastro-entero-pancreatic (GEP) NEN who received LuTate followed by quantitative SPECT/CT (Q-SPECT/CT) the next day (Jul 2010 to Jan 2019) were retrospectively reviewed. …”
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    The relationship between tumour dosimetry, response, and overall survival in patients with unresectable Neuroendocrine Neoplasms (NEN) treated with (177)Lu DOTATATE (LuTate)
  15. 75
    “…We provide the first [(18)F]SiTATE PET/CT data of a large cohort of meningioma patients. …”
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    Next-generation PET/CT imaging in meningioma—first clinical experiences using the novel SSTR-targeting peptide [(18)F]SiTATE
  16. 76
    “…TSH, and FT4, and iii. prolactin at or before day-30 of [(177)Lu]Lu-DOTA-TATE. No significant changes were observed in the gonadotropic axis and GH levels. …”
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    Early short-term effects on catecholamine levels and pituitary function in patients with pheochromocytoma or paraganglioma treated with [(177)Lu]Lu-DOTA-TATE therapy
  17. 77
    “…Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. …”
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    Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.)
  18. 78
    “…The aim of this study was to perform a side-by-side comparison of the in vitro and in vivo performance of (64)Cu-NODAGA-JR11 (NODAGA = 1,4,7-triazacyclononane,1-glutaric acid,4,7-acetic acid, JR11 = p-Cl-Phe-cyclo(D-Cys-Aph(Hor)-D-Aph(cbm)-Lys-Thr-Cys)D-Tyr-NH(2)), a somatostatin receptor 2 antagonist, with the clinically used sst2 agonist (64)Cu-DOTA-TATE ((TATE = D-Phe-cyclo(Cys-Tyr-D-Trp-Lys-Thr-Cys)Thr). …”
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    The somatostatin receptor 2 antagonist (64)Cu-NODAGA-JR11 outperforms (64)Cu-DOTA-TATE in a mouse xenograft model
  19. 79
    “…Objective: (177)Lu-DOTA-EB-TATE is a theranostic agent based on octreotate that uses an Evans blue structure to bind albumin to improve the pharmacokinetics and pharmacodynamics. …”
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    Response to Single Low-dose (177)Lu-DOTA-EB-TATE Treatment in Patients with Advanced Neuroendocrine Neoplasm: A Prospective Pilot Study
  20. 80
    “…PET/CT imaging with SSAs such as [(68)Ga]Ga-DOTA-TATE, [(68)Ga]Ga-DOTA-TOC, and [(68)Ga]Ga-DOTA-NOC allows for NET staging with high accuracy and is used to qualify patients for RLT. …”
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    The Search for an Alternative to [(68)Ga]Ga-DOTA-TATE in Neuroendocrine Tumor Theranostics: Current State of (18)F-labeled Somatostatin Analog Development
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