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232841por Sawula, Evan, Miersch, Shane, Jong, Eric D., Li, Chengjin, Chou, Fang-Yu, Tang, Jean Kit, Saberianfar, Reza, Harding, Jeffrey, Sidhu, Sachdev S., Nagy, Andras“…METHODS: Mouse embryonic stem cells equipped with our FailSafe™ and induced allogeneic cell tolerance technologies were engineered to express factors that potently neutralize SARS-CoV-2, which we call ‘neutralizing biologics’ (nBios). …”
Publicado 2023
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232842por Dammer, Eric B., Shantaraman, Anantharaman, Ping, Lingyan, Duong, Duc M., Gerasimov, Ekaterina S., Ravindran, Suda Parimala, Gudmundsdottir, Valborg, Frick, Elisabet A., Gomez, Gabriela T., Walker, Keenan A., Emilsson, Valur, Jennings, Lori L., Gudnason, Vilmundur, Western, Daniel, Cruchaga, Carlos, Lah, James J., Wingo, Thomas S., Wingo, Aliza P., Seyfried, Nicholas T., Levey, Allan I., Johnson, Erik C.B.“…Here we describe the proteomic landscape of cerebrospinal fluid (CSF) changes associated with Aβ and tau pathology in 300 individuals as assessed by two different proteomic technologies—tandem mass tag (TMT) mass spectrometry and SomaScan. …”
Publicado 2023
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232843por Afshari, Ali, Torabi, Mohammad, Navkhasi, Sasan, Aslani, Marzieh, Khazaei, Afshin“…Prehospital emergency stress can be reduced and managed more skillfully by adjusting various factors such as shortening workdays, offering continuous training, augmenting workforce, supplying ambulance equipment insurance, refraining from hiring personnel devoid of clinical training, hiring psychologists, hiring midwives in an emergency, updating prehospital protocols and guidelines, encouraging cooperation between EMTs and other relief groups, and utilizing cutting-edge technologies.…”
Publicado 2023
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232844por Schroeder, Marie A., Swietach, Pawel, Atherton, Helen J., Gallagher, Ferdia A., Lee, Phillip, Radda, George K., Clarke, Kieran, Tyler, Damian J.“…AIMS: Technological limitations have restricted in vivo assessment of intracellular pH (pH(i)) in the myocardium. …”
Publicado 2010
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232845por Maia, Ana-Teresa, Antoniou, Antonis C, O'Reilly, Martin, Samarajiwa, Shamith, Dunning, Mark, Kartsonaki, Christiana, Chin, Suet-Feung, Curtis, Christina N, McGuffog, Lesley, Domchek, Susan M, Easton, Douglas F, Peock, Susan, Frost, Debra, Evans, D Gareth, Eeles, Ros, Izatt, Louise, Adlard, Julian, Eccles, Diana, Sinilnikova, Olga M, Mazoyer, Sylvie, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Faivre, Laurence, Venat-Bouvet, Laurence, Delnatte, Capucine, Nevanlinna, Heli, Couch, Fergus J, Godwin, Andrew K, Caligo, Maria Adelaide, Barkardottir, Rosa B, Chen, Xiaoqing, Beesley, Jonathan, Healey, Sue, Caldas, Carlos, Chenevix-Trench, Georgia, Ponder, Bruce AJ“…SNPs tagging the expression haplotypes were correlated with the total expression of several genes in breast tissue measured by Taqman and microarray technologies. The effect of the expression haplotypes on breast cancer risk in BRCA2 mutation carriers was investigated in 2,754 carriers. …”
Publicado 2012
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232846por Gray, Kathleen Mary, Clarke, Ken, Kwong, Mabel, Alzougool, Basil, Hines, Carolyn, Tidhar, Gil, Frukhtman, Feodor“…IPTV may afford new opportunities for health care service providers to provide health information and for consumers, patients, and caretakers to access health information. The technologies of Web 2.0 add a new and even less explored dimension to IPTV’s potential. …”
Publicado 2014
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232847por Shaughnessy, Daniel T., McAllister, Kimberly, Worth, Leroy, Haugen, Astrid C., Meyer, Joel N., Domann, Frederick E., Van Houten, Bennett, Mostoslavsky, Raul, Bultman, Scott J., Baccarelli, Andrea A., Begley, Thomas J., Sobol, Robert W., Hirschey, Matthew D., Ideker, Trey, Santos, Janine H., Copeland, William C., Tice, Raymond R., Balshaw, David M., Tyson, Frederick L.“…Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways. …”
Publicado 2014
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232848por Manchanda, Ranjit, Loggenberg, Kelly, Sanderson, Saskia, Burnell, Matthew, Wardle, Jane, Gessler, Sue, Side, Lucy, Balogun, Nyala, Desai, Rakshit, Kumar, Ajith, Dorkins, Huw, Wallis, Yvonne, Chapman, Cyril, Taylor, Rohan, Jacobs, Chris, Tomlinson, Ian, McGuire, Alistair, Beller, Uziel, Menon, Usha, Jacobs, Ian“…BACKGROUND: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages. …”
Publicado 2014
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232849por Hill, Richard, Kalathur, Ravi Kiran Reddy, Callejas, Sergio, Colaço, Laura, Brandão, Ricardo, Serelde, Beatriz, Cebriá, Antonio, Blanco-Aparicio, Carmen, Pastor, Joaquín, Futschik, Matthias, Dopazo, Ana, Link, Wolfgang“…METHODS: We used a range of methodologies that include in silico compound analysis, in vitro kinase assays, cell invasion assays, proliferation assays, genome-wide transcription studies (Agilent Technologies full genome arrays), gene set enrichment analysis, quantitative real-time PCR, immunoblotting in addition to chromatin immunoprecipitation. …”
Publicado 2014
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232850por Saal, Lao H, Vallon-Christersson, Johan, Häkkinen, Jari, Hegardt, Cecilia, Grabau, Dorthe, Winter, Christof, Brueffer, Christian, Tang, Man-Hung Eric, Reuterswärd, Christel, Schulz, Ralph, Karlsson, Anna, Ehinger, Anna, Malina, Janne, Manjer, Jonas, Malmberg, Martin, Larsson, Christer, Rydén, Lisa, Loman, Niklas, Borg, Åke“…METHODS: To address these challenges, the Sweden Cancerome Analysis Network - Breast (SCAN-B) consortium was initiated in 2010 as a multicenter prospective study with longsighted aims to analyze breast cancers with next-generation genomic technologies for translational research in a population-based manner and integrated with healthcare; decipher fundamental tumor biology from these analyses; utilize genomic data to develop and validate new clinically-actionable biomarker assays; and establish real-time clinical implementation of molecular diagnostic, prognostic, and predictive tests. …”
Publicado 2015
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232851por Müller, Sören, Raulefs, Susanne, Bruns, Philipp, Afonso-Grunz, Fabian, Plötner, Anne, Thermann, Rolf, Jäger, Carsten, Schlitter, Anna Melissa, Kong, Bo, Regel, Ivonne, Roth, W Kurt, Rotter, Björn, Hoffmeier, Klaus, Kahl, Günter, Koch, Ina, Theis, Fabian J, Kleeff, Jörg, Winter, Peter, Michalski, Christoph W“…BACKGROUND: Previous studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological limitations of microarrays and real-time PCR systems these studies focused on a fixed set of targets. …”
Publicado 2015
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232852por Mitra, Suparna, Drautz-Moses, Daniela I., Alhede, Morten, Maw, Myat T., Liu, Yang, Purbojati, Rikky W., Yap, Zhei H., Kushwaha, Kavita K., Gheorghe, Alexandra G., Bjarnsholt, Thomas, Hansen, Gorm M., Sillesen, Henrik H., Hougen, Hans P., Hansen, Peter R., Yang, Liang, Tolker-Nielsen, Tim, Schuster, Stephan C., Givskov, Michael“…In spite of the progress in recent sequencing technologies, analyzing host-associated metagenomes remain a challenge. …”
Publicado 2015
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232853por Kilianski, Andy, Carcel, Patrick, Yao, Shijie, Roth, Pierce, Schulte, Josh, Donarum, Greg B., Fochler, Ed T., Hill, Jessica M., Liem, Alvin T., Wiley, Michael R., Ladner, Jason T., Pfeffer, Bradley P., Elliot, Oliver, Petrosov, Alexandra, Jima, Dereje D., Vallard, Tyghe G., Melendrez, Melanie C., Skowronski, Evan, Quan, Phenix-Lan, Lipkin, W. Ian, Gibbons, Henry S., Hirschberg, David L., Palacios, Gustavo F., Rosenzweig, C. Nicole“…CONCLUSIONS: By accurately detecting pathogens in a variety of samples, this work demonstrates the utility of Pathosphere and provides a platform for utilizing, modifying and creating pipelines for a variety of NGS technologies developed to detect pathogens in complex sample backgrounds. …”
Publicado 2015
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232854por Kadouch, Daniel J, Wolkerstorfer, Albert, Elshot, Yannick, Zupan-Kajcovski, Biljana, Crijns, Marianne B, Starink, Markus V, Bekkenk, Marcel W, van der Wal, Allard C, Spuls, Phyllis I, de Rie, Menno A“…OBJECTIVE: The aim of this research is to assess the efficacy and safety of a one-stop-shop (OSS) concept, using real-time in vivo reflectance confocal microscopy (RCM) (Vivascope 1500; Lucid Technologies, Henrietta, NY, USA) as a diagnostic tool, prior to surgical management of new primary BCCs. …”
Publicado 2015
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232855por Morton, Katie, Sutton, Stephen, Hardeman, Wendy, Troughton, Jacqui, Yates, Tom, Griffin, Simon, Davies, Melanie, Khunti, Kamlesh, Eborall, Helen“…BACKGROUND: Mobile technologies for health (mHealth) represent a promising strategy for reducing type 2 diabetes (T2DM) risk. …”
Publicado 2015
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232856por Calmels, Nadège, Greff, Géraldine, Obringer, Cathy, Kempf, Nadine, Gasnier, Claire, Tarabeux, Julien, Miguet, Marguerite, Baujat, Geneviève, Bessis, Didier, Bretones, Patricia, Cavau, Anne, Digeon, Béatrice, Doco-Fenzy, Martine, Doray, Bérénice, Feillet, François, Gardeazabal, Jesus, Gener, Blanca, Julia, Sophie, Llano-Rivas, Isabel, Mazur, Artur, Michot, Caroline, Renaldo-Robin, Florence, Rossi, Massimiliano, Sabouraud, Pascal, Keren, Boris, Depienne, Christel, Muller, Jean, Mandel, Jean-Louis, Laugel, Vincent“…Multiplex amplification and sequencing were performed using AmpliSeq protocol on the Ion Torrent PGM (Life Technologies). RESULTS: We identified causative mutations in 17 out of the 40 patients (43 %). …”
Publicado 2016
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232857por Ocampo, Joanne Michelle F, Smart, JC, Allston, Adam, Bhattacharjee, Reshma, Boggavarapu, Sahithi, Carter, Sharon, Castel, Amanda D, Collmann, Jeff, Flynn, Colin, Hamp, Auntré, Jordan, Diana, Kassaye, Seble, Kharfen, Michael, Lum, Garret, Pemmaraju, Raghu, Rhodes, Anne, Stover, Jeff, Young, Mary A“…However, traditional public health surveillance methods face substantial technological and privacy-related barriers to data sharing. …”
Publicado 2016
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232858por Mowery, Danielle L., South, Brett R., Christensen, Lee, Leng, Jianwei, Peltonen, Laura-Maria, Salanterä, Sanna, Suominen, Hanna, Martinez, David, Velupillai, Sumithra, Elhadad, Noémie, Savova, Guergana, Pradhan, Sameer, Chapman, Wendy W.“…BACKGROUND: The ShARe/CLEF eHealth challenge lab aims to stimulate development of natural language processing and information retrieval technologies to aid patients in understanding their clinical reports. …”
Publicado 2016
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232859por Maus, Irena, Koeck, Daniela E., Cibis, Katharina G., Hahnke, Sarah, Kim, Yong S., Langer, Thomas, Kreubel, Jana, Erhard, Marcel, Bremges, Andreas, Off, Sandra, Stolze, Yvonne, Jaenicke, Sebastian, Goesmann, Alexander, Sczyrba, Alexander, Scherer, Paul, König, Helmut, Schwarz, Wolfgang H., Zverlov, Vladimir V., Liebl, Wolfgang, Pühler, Alfred, Schlüter, Andreas, Klocke, Michael“…BACKGROUND: One of the most promising technologies to sustainably produce energy and to mitigate greenhouse gas emissions from combustion of fossil energy carriers is the anaerobic digestion and biomethanation of organic raw material and waste towards biogas by highly diverse microbial consortia. …”
Publicado 2016
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232860por Guo, Yi, Bian, Jiang, Leavitt, Trevor, Vincent, Heather K, Vander Zalm, Lindsey, Teurlings, Tyler L, Smith, Megan D, Modave, François“…With the rapid development of mobile technologies, mobile apps have the potential to improve participation rates in exercise programs, particularly if they are evidence-based and are of sufficient content quality. …”
Publicado 2017
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