“…To understand the role of miR-153 in the etiology of teratology, we first screened fetal cortical NSCs cultured ex vivo, by microarray and quantitative RT-PCR analyses, to identify cell-signaling mRNAs and gene networks as important miR-153 targets. …”
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“…Among 1,026 callers at the Korean Teratology Information Service from 2001 to 2017 exposed to isotretinoin during the periconception period, 151 pregnant women who received counseling on teratogenic risk after visiting the clinic were included. …”
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“…The most popular source of information on the safety of drug use during pregnancy is the Dutch National Health Insurance System Formulary, while a minority of respondents contacts the Dutch national Teratology Information Service (TIS). The majority of GPs contact the pharmacy with questions concerning drug use during pregnancy. …”
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“…METHODS AND FINDINGS: Between 2004 and 2016, the Organization of Teratology Information Specialists Research Center at the University of California San Diego conducted a prospective controlled observational cohort study in 602 pregnant women who had or had not taken adalimumab. …”
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“…However, mechanisms that link EtOH exposure to teratology in these regions are not well understood. …”
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“…The patient consulted our teratology information service for further risk assessment regarding possible major congenital malformations following the paroxetine overdose. …”
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“…RESULTS: Early treatment with 5-aza-dC altered embryonic development, delayed hatching and increased teratology and mortality, as expected. The most striking result, however, was an increase in the number of females, suggesting that alterations induced by 5-aza-dC treatment can affect sexual development as well. …”
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“…The key findings are: 1) None of these PCBs caused death or overt teratology at the concentrations tested; 2) A subset of these PCB congeners altered photomotor behavior in larval zebrafish and the SAR for PCB behavioral effects mirrored the SAR for RYR sensitization; and 3) Quantification of PCB levels in larval zebrafish ruled out the possibility that congener-specific effects on behavior were due to differential uptake of PCB congeners. …”
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“…Setting: Data from the Organization of Teratology Information Specialists (OTIS) Antidepressants in Pregnancy Cohort, 2006–2010, were used. …”
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“…We approached both the Netherlands Pharmacovigilance Centre Lareb on January 17(th) 2023 and the Teratology Information Service (TIS) of Switzerland on February 6(th) 2023. …”
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“…Not only are these results of concern in themselves, but they further imply that our list of the congenital teratology of cannabis is as yet incomplete, and highlight in particular cardiovascular toxicology of prenatal cannabinoid and drug exposure. …”
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“…Accurate and uniform teratology information should be made more available to the public.…”
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“…The literature had revealed that records of adult animals with morphological abnormalities (teratologies) are fewer in species with complex life cycle than in those with direct development. …”
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“…Valproic acid (2-propyl pentanoic acid), ethylhexanoic acid, and octanoic acid are isomeric C8 organic acids but their teratologic potency varied widely. Valproic acid induced a moderate to severe teratologic outcome after a single oral administration of 6.25 mmoles/kg on day 12 of rat pregnancy. …”
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“…Throughout the last four centuries, many anatomical museums across the world have collected teratological specimens that became precious objects. …”
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“…The experimental work in this field has revealed a partial, however complex, answer to the teratological question, and we will review some of the latest suggestions.…”
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“…To the best of our knowledge, this is the first report of teratological changes in H. qinghaiensis. The abnormal morphological features are described herein.…”
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“…Within the realm of clubfoot deformities, teratologic and complex (or atypical) clubfeet stand out as the most difficult. …”
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“…CONCLUSIONS: Potential teratologic effects of MMA cannot be excluded by existing evidence. …”
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“…While mice have been used less frequently than rats in behavioral research, there use has some advantages in teratological studies. The development of the mouse CNS has been investigated more extensively than that of the rat. …”
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