Mostrando 1 - 20 Resultados de 290 Para Buscar '"That 90's show"', tiempo de consulta: 4.54s Limitar resultados
  1. 1
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    TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia
  2. 2
    “…Here, we report recent findings on Hsp10 and Hsp90 and show that the quantitative and topographic patterns of tissue Hsp90 are distinctive of malignant tumors and differentiate benign from malignant lesions. …”
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    The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors
  3. 3
    por Leask, Andrew
    Publicado 2009
    “…In a recent report, Hirschfeld and colleagues (Cancer Res 69:2082-90, 2009), show that CCN1 (cyr61) mRNA is normally present in a form in which intron 3 is retained. …”
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    What’s in an intron? CCN1 mRNA splicing in cancer
  4. 4
    por Larsen, Robert Garbrecht
    Publicado 2022
    “…Test with a Strontium-90 source show a high possible efficiency.…”
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    Development of radiation hard sensing fibres for FLASH therapy and the CERN Experimental Areas
  5. 5
    “…Charge collection studies on irradiated devices with a Sr-90 source show higher charge collection efficiency for 3D over planar sensors at significantly lower applied bias. …”
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    Characterisation of Glasgow/CNM Double-Sided 3D Sensors
  6. 6
    “…By studying truncated versions of Pho87 and Pho90, we show that the SPX domain limits the phosphate-uptake velocity, suppresses phosphate efflux and affects the regulation of the phosphate signal transduction pathway. …”
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    The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity
  7. 7
    “…It is not currently known in what state (folded, unfolded, alternatively folded) client proteins interact with chaperone Hsp90. We show that one client, the p53 DNA-binding domain, undergoes a structural change in the presence of Hsp90 to adopt a molten globule-like state. …”
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    The client protein p53 forms a molten globule-like state in the presence of Hsp90
  8. 8
    “…Here, we report a microfluidic-based method for encapsulating single cells in a ~6 micron layer of alginate that increases the proportion of cell-containing microgels by 10-fold, with encapsulation efficiencies over 90%. We show that in vitro cell viability was maintained over a three-day period, that the microgels are mechanically tractable, and that for microscale cell assemblages of encapsulated marrow stromal cells cultured in microwells, osteogenic differentiation of encapsulated cells depends on gel stiffness and cell density. …”
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    Deterministic encapsulation of single cells in thin tunable microgels for niche modeling and therapeutic delivery
  9. 9
    “…Data on deaths of Sicilian 90 + years show that, in line with what is known about the different response to infections between the two genders, oldest females are more resilient to COVID-19 than males. …”
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    Centenarians born before 1919 are resistant to COVID-19
  10. 10
    Publicado 1989
    “…J. Cell Biol. 83:82-90). We show here that in the absence of extracellular Na+ or in the presence of amiloride the stimulation of pinocytosis by EGF is substantially reduced. …”
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    Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]
  11. 11
    “…We yielded very reliable results with high accuracy (93%) and precision (90%). We show that topologic, genomic and transcriptomic features describing the network are sufficient for defining the essentiality of a reaction. …”
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    Machine learning based analyses on metabolic networks supports high-throughput knockout screens
  12. 12
    “…The crystal structures of RSFP apo form (1.98 Å) and complex RSFP/RB (1.90 Å) show a trimer of RSFP molecules located on the crystallographic six fold screw axis. …”
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    A Study on the Interaction of Rhodamine B with Methylthioadenosine Phosphorylase Protein Sourced from an Antarctic Soil Metagenomic Library
  13. 13
    “…In addition, most cases (60%‐90%) also show evidence of Epstein‐Barr virus (EBV) infection. …”
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    Primary effusion lymphoma in human immune deficiency (HIV)‐negative non‐organ transplant immunocompetent patients
  14. 14
    “…Since the study has used structural equation modelling approach to test the hypothesis and figure out the relative importance of the factors, the fundamental indices such as Normed Chi square(less than 3), RMSEA (less than 0.08) and CFI (more than 0.90) values show the overall model fit of the proposed model. …”
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    Factors Affecting the Attractiveness of Medical Tourism Destination: An Empirical Study on India- Review Article
  15. 15
    “…Heat shock protein 90 (HSP90) is an important chaperone in lung adenocarcinoma, with relevant protein drivers such as EGFR (epidermal growth factor receptor) and EML4-ALK (echinoderm microtubule-associated protein-like protein4 fused to anaplastic lymphoma kinase) depending on it for their correct function, therefore HSP90 inhibitors show promise as potential treatments for lung adenocarcinoma. …”
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    Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry
  16. 16
    “…Our combined findings provide a mechanistic model for the coupling between catalysis and protein dynamics in Hsp90, and show how long-range coupling effects can modulate enzymatic activity.…”
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    Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
  17. 17
    “…The coated NCs are readily dispersible and highly stable in short-chain alcohols while remaining monodisperse and exhibiting high PLQY (70–90%). We show the successful coating of NCs in a wide range of sizes (5–14 nm) and halide compositions. …”
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    Colloidal CsPbX(3) Nanocrystals with Thin Metal Oxide Gel Coatings
  18. 18
    “…Cyclophilin 40 (Cyp40) comprises an N-terminal cyclophilin domain with peptidyl-prolyl isomerase (PPIase) activity and a C-terminal tetratricopeptide repeat (TPR) domain that binds to the C-terminal–EEVD sequence common to both heat shock protein 70 (Hsp70) and Hsp90. We show in the present study that binding of peptides containing the MEEVD motif reduces the PPIase activity by ∼30%. …”
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    Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90
  19. 19
    “…Additionally, the mean daily precipitation intensity (SDII), the maximum 5-day precipitation values (RX5Day), and the heavy precipitation events—represented by the width of the right tail distribution of precipitation (99p–90p)—show an increase of 16%, 29%, and 47%, respectively, by the end of the century. …”
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    Extreme climatic events to intensify over the Lake Victoria Basin under global warming
  20. 20
    “…Here, we present a co-crystal structure of LA1011 in complex with a fragment of Hsp90. We show that LA1011 can disrupt the binding of FKBP51, which might help to rebalance the Hsp90-FKBP51 chaperone machinery and provide a favourable prognosis towards AD. …”
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    The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer’s Disease
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