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1por Ikebe, Emi, Shimosaki, Shunsuke, Hasegawa, Hiroo, Iha, Hidekatsu, Tsukamoto, Yoshiyuki, Wang, Yu, Sasaki, Daisuke, Imaizumi, Yoshitaka, Miyazaki, Yasushi, Yanagihara, Katsunori, Hamaguchi, Isao, Morishita, KazuhiroEnlace del recurso
Publicado 2021
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2por Basset, Charbel A., Rappa, Francesca, Barone, Rosario, Florena, Ada Maria, Porcasi, Rossana, Conway de Macario, Everly, Macario, Alberto J. L., Leone, Angelo“…Here, we report recent findings on Hsp10 and Hsp90 and show that the quantitative and topographic patterns of tissue Hsp90 are distinctive of malignant tumors and differentiate benign from malignant lesions. …”
Publicado 2022
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3por Leask, Andrew“…In a recent report, Hirschfeld and colleagues (Cancer Res 69:2082-90, 2009), show that CCN1 (cyr61) mRNA is normally present in a form in which intron 3 is retained. …”
Publicado 2009
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4por Larsen, Robert Garbrecht“…Test with a Strontium-90 source show a high possible efficiency.…”
Publicado 2022
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5por Raighne, Aaron Mac, Akiba, K, Balbuena, J P, Bates, R, van Beuzekom, M, Buytaert, J, Collins, P, Crossley, M, Dumps, R, Eklund, L, Fleta, C, Gallas, A, Gersabeck, M, Gligorov, V V, John, M, Köhler, M, Lozano, M, Maneuski, D, Parzefall, U, Quirion, D, Plackett, R, Parkes, C, Pellegrini, G, Rodrigues, E, Stewart, G“…Charge collection studies on irradiated devices with a Sr-90 source show higher charge collection efficiency for 3D over planar sensors at significantly lower applied bias. …”
Publicado 2012
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6por Hürlimann, Hans Caspar, Pinson, Benoît, Stadler-Waibel, Martha, Zeeman, Samuel C, Freimoser, Florian M“…By studying truncated versions of Pho87 and Pho90, we show that the SPX domain limits the phosphate-uptake velocity, suppresses phosphate efflux and affects the regulation of the phosphate signal transduction pathway. …”
Publicado 2009
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7“…It is not currently known in what state (folded, unfolded, alternatively folded) client proteins interact with chaperone Hsp90. We show that one client, the p53 DNA-binding domain, undergoes a structural change in the presence of Hsp90 to adopt a molten globule-like state. …”
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8por Mao, Angelo S., Shin, Jae-Won, Utech, Stefanie, Wang, Huanan, Uzun, Oktay, Li, Weiwei, Cooper, Madeline, Hu, Yuebi, Zhang, Liyuan, Weitz, David A., Mooney, David J.“…Here, we report a microfluidic-based method for encapsulating single cells in a ~6 micron layer of alginate that increases the proportion of cell-containing microgels by 10-fold, with encapsulation efficiencies over 90%. We show that in vitro cell viability was maintained over a three-day period, that the microgels are mechanically tractable, and that for microscale cell assemblages of encapsulated marrow stromal cells cultured in microwells, osteogenic differentiation of encapsulated cells depends on gel stiffness and cell density. …”
Publicado 2016
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9por Caruso, Calogero, Accardi, Giulia, Aiello, Anna, Calabrò, Anna, Ligotti, Mattia Emanuela, Candore, Giuseppina“…Data on deaths of Sicilian 90 + years show that, in line with what is known about the different response to infections between the two genders, oldest females are more resilient to COVID-19 than males. …”
Publicado 2022
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10Publicado 1989“…J. Cell Biol. 83:82-90). We show here that in the absence of extracellular Na+ or in the presence of amiloride the stimulation of pinocytosis by EGF is substantially reduced. …”
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11por Plaimas, Kitiporn, Mallm, Jan-Phillip, Oswald, Marcus, Svara, Fabian, Sourjik, Victor, Eils, Roland, König, Rainer“…We yielded very reliable results with high accuracy (93%) and precision (90%). We show that topologic, genomic and transcriptomic features describing the network are sufficient for defining the essentiality of a reaction. …”
Publicado 2008
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12por Bartasun, Paulina, Cieśliński, Hubert, Bujacz, Anna, Wierzbicka-Woś, Anna, Kur, Józef“…The crystal structures of RSFP apo form (1.98 Å) and complex RSFP/RB (1.90 Å) show a trimer of RSFP molecules located on the crystallographic six fold screw axis. …”
Publicado 2013
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13“…In addition, most cases (60%‐90%) also show evidence of Epstein‐Barr virus (EBV) infection. …”
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14“…Since the study has used structural equation modelling approach to test the hypothesis and figure out the relative importance of the factors, the fundamental indices such as Normed Chi square(less than 3), RMSEA (less than 0.08) and CFI (more than 0.90) values show the overall model fit of the proposed model. …”
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15por Marrugal, Ángela, Ferrer, Irene, Pastor, Maria Dolores, Ojeda, Laura, Quintanal-Villalonga, Álvaro, Carnero, Amancio, Molina-Pinelo, Sonia, Paz-Ares, Luis“…Heat shock protein 90 (HSP90) is an important chaperone in lung adenocarcinoma, with relevant protein drivers such as EGFR (epidermal growth factor receptor) and EML4-ALK (echinoderm microtubule-associated protein-like protein4 fused to anaplastic lymphoma kinase) depending on it for their correct function, therefore HSP90 inhibitors show promise as potential treatments for lung adenocarcinoma. …”
Publicado 2019
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16por Mader, Sophie L., Lopez, Abraham, Lawatscheck, Jannis, Luo, Qi, Rutz, Daniel A., Gamiz-Hernandez, Ana P., Sattler, Michael, Buchner, Johannes, Kaila, Ville R. I.“…Our combined findings provide a mechanistic model for the coupling between catalysis and protein dynamics in Hsp90, and show how long-range coupling effects can modulate enzymatic activity.…”
Publicado 2020
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17por Guggisberg, Dominic, Yakunin, Sergii, Neff, Christoph, Aebli, Marcel, Günther, Detlef, Kovalenko, Maksym V., Dirin, Dmitry N.“…The coated NCs are readily dispersible and highly stable in short-chain alcohols while remaining monodisperse and exhibiting high PLQY (70–90%). We show the successful coating of NCs in a wide range of sizes (5–14 nm) and halide compositions. …”
Publicado 2023
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18por Blackburn, Elizabeth A., Wear, Martin A., Landré, Vivian, Narayan, Vikram, Ning, Jia, Erman, Burak, Ball, Kathryn L., Walkinshaw, Malcolm D.“…Cyclophilin 40 (Cyp40) comprises an N-terminal cyclophilin domain with peptidyl-prolyl isomerase (PPIase) activity and a C-terminal tetratricopeptide repeat (TPR) domain that binds to the C-terminal–EEVD sequence common to both heat shock protein 70 (Hsp70) and Hsp90. We show in the present study that binding of peptides containing the MEEVD motif reduces the PPIase activity by ∼30%. …”
Publicado 2015
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19“…Additionally, the mean daily precipitation intensity (SDII), the maximum 5-day precipitation values (RX5Day), and the heavy precipitation events—represented by the width of the right tail distribution of precipitation (99p–90p)—show an increase of 16%, 29%, and 47%, respectively, by the end of the century. …”
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20por Roe, S. Mark, Török, Zsolt, McGown, Andrew, Horváth, Ibolya, Spencer, John, Pázmány, Tamás, Vigh, László, Prodromou, Chrisostomos“…Here, we present a co-crystal structure of LA1011 in complex with a fragment of Hsp90. We show that LA1011 can disrupt the binding of FKBP51, which might help to rebalance the Hsp90-FKBP51 chaperone machinery and provide a favourable prognosis towards AD. …”
Publicado 2023
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