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  1. 259641
    “…BACKGROUND: Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. …”
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    Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish Medical Birth Register
  2. 259642
    “…CONCLUSIONS: Compared to val monotherapy, sac/val was more effective in reducing proteinuria, renal ultrastructure and tubular injury in a clinically relevant animal model of early DN. More importantly, these renoprotective effects were independent of improvements in blood pressure, glycemia and nitroso-oxidative stress. …”
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    The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat
  3. 259643
    “…BACKGROUND: The increasing amounts of genomics data have helped in the understanding of the molecular dynamics of complex systems such as plant and animal diseases. However, transcriptional regulation, although playing a central role in the decision-making process of cellular systems, is still poorly understood. …”
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    Gene regulatory networks on transfer entropy (GRNTE): a novel approach to reconstruct gene regulatory interactions applied to a case study for the plant pathogen Phytophthora infestans
  4. 259644
    “…Suppression of Dicer, an endoribonuclease that regulates microRNAs(miRNA), has evolved as a viral mechanism to enhance host HIV infectivity and may have unintended metabolic consequences. Animal knockout models of adipose-specific dicer(ADicer) acquire lipodystrophy accompanied by severe metabolic abnormalities. …”
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    MON-100 Unique miRNA Signature in HIV Lipodystrophy with Reduced Adipose Dicer Expression
  5. 259645
    “…J Endocrinol 2018) that there is no established animal model to investigate GC effects on skeletal development. …”
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    SAT-530 Establishment of a Glucocorticoid (GC) Regimen to Induce Both Growth Retardation and Osteoporosis in C57BL/10 Muscular Dystrophy Mouse Models
  6. 259646
    “…This study was approved by the Experimental Animal Ethics Committee of Shandong University of China in April 2016 (approval No. …”
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    Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection
  7. 259647
    “…BACKGROUND: Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. …”
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    Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
  8. 259648
    “…HCPs experienced the OneTouch Verio Reflect glucose meter and the OneTouch Reveal mobile app online from their own office computers using interactive demonstrations via webpages and multiple animations. After providing demographic and clinical practice insights, HCPs responded to statements about the utility of the system. …”
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    Health Care Professionals’ Clinical Perspectives and Acceptance of a Blood Glucose Meter and Mobile App Featuring a Dynamic Color Range Indicator and Blood Sugar Mentor: Online Evaluation in Seven Countries
  9. 259649
    “…This suggested that our materials were safe and could be applied as a type of potential biomaterial in the future. 6) Further animal studies demonstrated that the implant was in good position without dislocation. …”
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    3D printed zirconia ceramic hip joint with precise structure and broad-spectrum antibacterial properties
  10. 259650
    “…Furthermore, the available material does not provide clear information on the ventral organization of this animal, obscuring our understanding of phylogenetically significant details such as the appendages. …”
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    The appendicular morphology of Sinoburius lunaris and the evolution of the artiopodan clade Xandarellida (Euarthropoda, early Cambrian) from South China
  11. 259651
    “…This is the first report of exercise protection in an adult adRP animal model. It is also the first report of an RPE phenotype in the I307N Rho mouse. …”
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    Wheel running exercise protects against retinal degeneration in the I307N rhodopsin mouse model of inducible autosomal dominant retinitis pigmentosa
  12. 259652
    “…METHODS/STUDY POPULATION: Mechanical loading: The NYU School of Medicine Institutional Animal Care and Use Committee approved all procedures. …”
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    2010 Use it but still lose it: Exploring age-related changes in skeletal stem cell location and activation in response to physical stimulation
  13. 259653
    “…Verify the impact of novel variants in independent samples: In silico (analyze genetic databases for suspected variants), in vivo (assess bleeding in animal models of hemophilia after introducing presumed modifier variants). 2. …”
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    3409 The Power of Phenotypic Extremes in Detecting Novel Genetic Modifiers of Hemophilia
  14. 259654
    “…METHODS/STUDY POPULATION: Wild-type Sprague-Dawley rats were inoculated with an adenoviral vector containing bioactive TGF-beta or sham at 1×10(9) pfu/animal placed in the left nares. Seven days post-inoculation, functional, and biochemical measures were conducted. …”
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    2058 miRNA manipulation to improve CFTR correction in cystic fibrosis
  15. 259655
    “…The cells were also tested in vivo in a large animal model. IVD degeneration was induced after an annular puncture in pigs, 4 weeks later the cells were injected and IVDs were analyzed at 12 weeks after the injury using MRI, gene expression analysis and histology. …”
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    Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model
  16. 259656
    “…Minocycline is anti-inflammatory, protects against the toxic effects of β-amyloid in vitro and in animal models of AD, and is a credible repurposed treatment candidate. …”
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    Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial
  17. 259657
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    Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves
  18. 259658
    “…In this study we utilized a flow fluid shear stress (FFSS) model in cultured chondrocytes and a unilateral anterior crossbite (UAC) animal model. We found that both FFSS and UAC actively induced endoplasmic reticulum stress (ERS) in the temporomandibular joints (TMJ) chondrocytes, as demonstrated by dramatic increases in expression of HSPA5, p-EIF2AK3, p-ERN1 and ATF6. …”
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    MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint
  19. 259659
    “…METHODS: We performed cell‐based in vitro and animal in vivo experiments. The atrophic effect of SAA1 on differentiated C2C12 myotubes was investigated by analysing gene expression, protein content, and the atrophy phenotype. …”
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    Serum amyloid A1 mediates myotube atrophy via Toll‐like receptors
  20. 259660
    “…Different types of alteration were often seen in the same animal and even the same tissue. There was no obvious correlation between the cat's age, gross pathological changes, and the histological types of alteration. …”
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    Cellular composition, coronavirus antigen expression and production of specific antibodies in lesions in feline infectious peritonitis
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