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  1. 259681
    “…The receiver operating characteristic (ROC) analysis illustrated that the area under the curve was 0.80 (95% confidence interval [CI] 0.71–0.89; P < 0.001) and the optimal cut-off value of serum O-sulfotyrosine suggesting AKI was < 147.40 ng/mL with a sensitivity and specificity of 80.90 and 70.00% respectively. In animal experiments, serum levels of O-sulfotyrosine in mice were elevated on Day 7 after 5/6 nephrectomy (14.89 ± 1.05 vs. 8.88 ± 2.62 ng/mL, P < 0.001) until Day 90 (32.65 ± 5.59 vs. 8.88 ± 2.62 ng/mL, P < 0.001). …”
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    Using circulating O-sulfotyrosine in the differential diagnosis of acute kidney injury and chronic kidney disease
  2. 259682
    “…Following LPS, there were significant differences between cohort and change in HA fraction (p = 0.03) and TLBF (p = 0.01) with BDL baseline HA fraction (46.2 ± 4.6%) reducing (− 20.9 ± 7.5%, p = 0.03) but sham baseline HA fraction (38.2 ± 2.0%) remaining unchanged (+ 2.9 ± 6.1%, p > 0.99). Animal cohort and change in systolic function interactions were significant only for heart rate (p = 0.01) and end-diastolic volume (p = 0.03). …”
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    Haemodynamic changes in cirrhosis following terlipressin and induction of sepsis—a preclinical study using caval subtraction phase-contrast and cardiac MRI
  3. 259683
    “…Background: Glaucoma is an irreversible and blinding neurodegenerative disease that is characterized by progressive loss of retinal ganglion cells. The current animal models of glaucoma fail to provide a chronic elevated intraocular pressure and cannot maintain the optical media clarity for a long time, which brings some difficulties to the study of glaucoma. …”
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    Evaluation of the Effectiveness of a Chronic Ocular Hypertension Mouse Model Induced by Intracameral Injection of Cross-Linking Hydrogel
  4. 259684
    “…However, most evidence arises from animal models while there is limited data in humans. …”
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    Severe Disease Activity and Liver Fibrosis Are Associated With a Lack of Hepatic Mitochondrial Adaptation in Patients With NASH
  5. 259685
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    Oral administration of Moringa oleifera leaf powder relieves oxidative stress, modulates mucosal immune response and cecal microbiota after exposure to heat stress in New Zealand White rabbits
  6. 259686
    “…After removing reviews, meta-analyses, animal studies and etc., 15 articles were eligible and included in this review. …”
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    Revealing the Neural Mechanism Underlying the Effects of Acupuncture on Migraine: A Systematic Review
  7. 259687
    “…Conclusion: ET-26HCl exerts mild, reversible effects on respiratory, cardiovascular, and central nervous system function as verified by standard in vivo animal models.…”
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    Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs
  8. 259688
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    Effects of supplements differing in fatty acid profile to late gestational beef cows on cow performance, calf growth performance, and mRNA expression of genes associated with myogenesis and adipogenesis
  9. 259689
    “…IMPORTANCE: Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. …”
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    Association of Cannabis Use During Adolescence With Neurodevelopment
  10. 259690
    “…Tumor growth was observed in male BALB/c nude mice (Shanghai Experimental Animal Center) based on Eca109 cell implantation, raising, and measurement. …”
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    Effect of silencing C-erbB-2 on esophageal carcinoma cell biological behaviors by inhibiting IGF-1 pathway activation
  11. 259691
    “…We excluded deaths due to animal bites and stings, ethanol or methanol poisoning, and gas inhalation as well as papers reporting a single death (case study of single patient). …”
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    Importance of pesticides for lethal poisoning in India during 1999 to 2018: a systematic review
  12. 259692
    “…Transcriptomic analysis of endothelial cells revealed that sex of the animal was a major determinant of gene expression differences. …”
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    Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains
  13. 259693
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    Estimates of genomic inbreeding and identification of candidate regions that differ between Chinese indigenous sheep breeds
  14. 259694
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    Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta
  15. 259695
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    Regulation of bone phosphorus retention and bone development possibly by related hormones and local bone-derived regulators in broiler chicks
  16. 259696
    “…Drug safety hazards caused by the above-mentioned issues have been identified with different products and formulations, from small molecules to complex molecules such as biological products extracted from animal sources, biosimilars and advanced therapy medicinal products. …”
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    Monitoring the manufacturing and quality of medicines: a fundamental task of pharmacovigilance
  17. 259697
    “…Severe food insecurity was associated with intentional injuries (adjusted rate ratio [aRR] 1.81; 95% CI 1.29–2.53) including self-harm (aRR 1.87; 95% CI 1.03–3.40) and violence (aRR 1.79; 95% CI 1.19–2.67) as well as non-intentional injuries (aRR 1.34; 95% CI 1.22–1.46) including fall (aRR 1.43; 95% CI 1.24–1.65), medical complication (aRR 1.39; 95% CI 1.06–1.82), being struck by objects (aRR 1.43; 95% CI 1.07–1.91), overexertion (aRR 1.31; 95% CI 1.04–1.66), animal bite or sting (aRR 1.60; 95% CI 1.08–2.36), skin piercing (aRR 1.80; 95% CI 1.21–2.66), and poisoning (aRR 1.65; 95% CI 1.05–2.59). …”
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    Examining the relationship between food insecurity and causes of injury in Canadian adults and adolescents
  18. 259698
    por Tulipan, Julia, Kofler, Barbara
    Publicado 2021
    “…Numerous preclinical studies in different animal models of cancer have examined the effect of KDs on cancer growth, but no large randomized controlled studies or prospective cohort studies are available for human cancer patients. …”
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    Implementation of a Low-Carbohydrate Diet Improves the Quality of Life of Cancer Patients – An Online Survey
  19. 259699
    “…Ongoing research transplants these islets into animal models of diabetes to validate in vivo function. …”
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    Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture
  20. 259700
    “…We measured the effects of an animated, mobile video series, the Philani MObile Video Intervention for Exclusive breastfeeding (MOVIE), delivered by a cadre of CHWs (“mentor mothers”). …”
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    Evaluation of a community-based mobile video breastfeeding intervention in Khayelitsha, South Africa: The Philani MOVIE cluster-randomized controlled trial
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