“…Climate change is predicted to affect the pattern of resource fluctuations across much of the southern hemisphere, where nomadism is the dominant form of animal movement, so it is critical we begin to understand the consequences of this for accurate threat assessment of nomadic species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…WIDER IMPLICATIONS OF THE FINDINGS: In vitro activation of follicle growth may compromise the bidirectional signalling between oocyte and granulosa cells necessary for optimal oocyte and follicle health. This large animal model may be useful in optimising follicle activation protocols with a view to transfer for clinical application. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…STUDY DESIGN, SIZE, DURATION: In this study, we used marmoset as a pre-clinical animal model. ITT was obtained from two 6-month-old co-twin marmosets. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background: Exercise therapy has been widely applied in clinical rehabilitation as an important practical and side effect—free adjuvant therapy, with a significant effect in alleviating motor dysfunction of patients with Parkinson’s disease (PD) or animal PD models. This study focuses on the effect of exercise therapy in reducing the concentration of extracellular glutamate (Glu) in the striatum in a rat PD model by upregulating the expression of group II metabotropic Glu receptor (mGluR2/3), so as to alleviate motor dysfunction in the rat PD model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One tailed ANOVA followed by Dunnett’s post-hoc test was used to establish significance. All animal experiments were conducted as described in approved IACUC protocols. …”
Enlace del recurso
Enlace del recurso

“…WHAT IS KNOWN ALREADY: Animal studies indicate that the embryo culture environment affects the DNA methylation status of the embryo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: The in vitro investigation of the novel compounds alongside with the reference peptides PentixaFor and PentixaTher encompassed the determination of hCXCR4 and mCXCR4 affinity (IC(50)) of the respective (nat)Ga-, (nat)Lu-, (nat)Y- and (nat)Bi-complexes in Jurkat and Eμ-myc 1080 cells using [(125)I]FC-131 and [(125)I]CPCR4.3 as radioligands, respectively, as well as the evaluation of the internalization and externalization kinetics of selected (68)Ga- and (177)Lu-labeled compounds in hCXCR4-transfected Chem-1 cells. Comparative small animal PET imaging studies (1h p.i.) as well as in vivo biodistribution studies (1, 6 and 48h p.i.) were performed in Daudi (human B cell lymphoma) xenograft bearing CB17 SCID mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…La négativité des sérologies pourrait s’expliquer par une déplétion lymphocytaire B transitoire induite par l’INF-1, ainsi que décrite chez l’animal en réponse à une infection au virus de la chorioméningite lymphocytaire. …”
Enlace del recurso
Enlace del recurso

“…Such morphometric, behavioral, growth-related, and reproductive advantages shown by the HSR-goats gave evidence to emphasize the need to better comprehend the biological foundation of relevant animal traits, and to be able to define future balanced management and breeding programs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, the efficacy and side effects of L-dopa treatment are extremely heterogeneous across Parkinson’s patients, and this variability cannot be completely explained by differences in host metabolism RATIONALE: Previous studies in humans and animal models have demonstrated that the gut microbiota can metabolize L-dopa. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Trainee research was also severely impacted as laboratories closed, experimental animal colonies were lost, and many research activities ceased. …”
Enlace del recurso
Enlace del recurso

“…Ironically, it has the potential of increasing the risk of recurrent anterior uveitis because of its ability to attach to TNF-beta, which is important for uveal health as proven in animal models. Therefore, in this case the diagnostic accuracy is imperative as the choice of treatment could cause adverse effects if it was wrong.…”
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…In addition, HE staining and oil red O staining showed obvious AS plaque formation in the vessel wall, and a large amount of fat deposition in VSMC, thus indicating that the hyperhomocysteinemia As an animal model was successfully established. Furthermore, CTRP9 were downregulated, while GRP78, p-PERK, ATF6a, p-IRE1α, SREBP1c, SREBP2 was upregulated in aortic VSMC in the ApoE(−/−) + HMD group. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This is in accord with findings in both human RA and animal models of RA that show that inflammation and tissue destruction sometimes are uncoupled processes. …”
Enlace del recurso
Enlace del recurso

“…Regardless of elaborate serological studies and animal experiments, streptococci must be recovered consistently by several groups of laboratory workers before their etiologic rôle in chronic arthritis and rheumatic fever can be accepted. …”
Enlace del recurso
Enlace del recurso

“…Articles published in the English language between January 1, 1990 and March 1, 2017 were identified and isolated based on the analysis of p53 in skeletal muscle in both animal and cell culture models. Results: Literature was categorized according to the modality of imposed oxidative stress including exercise, diet modification, exogenous oxidizing agents, tissue manipulation, irradiation, and hypoxia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Utilizing a moderately-sized animal, we can feasibly implant mesh using the “gold standard” abdominal sacrocolpopexy procedure and evaluate the changes in the host immunologic response at early (14 d) and tissue remodeling outcomes at late stages (90 and 180 d) of implantation. …”
Enlace del recurso
Enlace del recurso

“…WHAT IS KNOWN ALREADY: In vivo developed embryos studied in animal models possess different characteristics compared to in vitro developed embryos of similar species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso