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1548341por Zhou, Cuiqi, Bonert, Vivien, Mamelak, Adam, Kelly, Daniel, Barkhoudarian, Garni, Hoon, Dave, Komagata, Tatsuya, Shinozaki, Koji, Melmed, Shlomo“…High baseline SST2 expression further validated by Western blot and confocal immunofluorescence, imply that SST receptor expression associates with ONO-ST1-641 responsiveness. Available SRLs and GHR antagonists are parenteral, requiring lifelong injection, with variable and suboptimal efficacy, necessitating development of novel oral small molecule drugs for acromegaly. …”
Publicado 2019
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1548342por Yang, Yashuang, Wang, Xiaolei, Shao, Shanshan, Chen, Wenbin, Bo, Tao, Zhao, Jiajun, Gao, Ling“…It is reported that tRFs, especially tiRNA-5 associated with stress. However, whether tRFs connect with NAFLD is unclear. …”
Publicado 2019
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1548343“…Recent studies have shown that TIR has a similar association with diabetes microvascular complications as does HbA1c (1,2). …”
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1548344por Du, Wen, He, Jing, Zhou, Wei, Shu, Simin, Li, Juan, Liu, Wei, Deng, Yun, Lu, Cong, Lin, Shengyan, Ma, Yaokun, He, Yanli, Zheng, Jine, Zhu, Jiang, Bai, Lijuan, Li, Xiaoqing, Yao, Junxia, Hu, Dan, Gu, Shengqing, Li, Huiyu, Guo, Anyuan, Huang, Shiang, Feng, Xiaolan, Hu, Dong“…BACKGROUND: Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). …”
Publicado 2019
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1548345por Wijetunga, Udai, Bulugahapitiya, Uditha, Wijeratne, Thejana, Jayasuriya, Anuradha, Ratnayake, Gowri, Kaluarachchi, Vidumini, Gunatilake, Sonali, Silva, Charini, Gunawardena, Asela“…Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity with prevalence rates of 65 - 85% in obese individuals. It can be associated liver cell injury eventually leading to cirrhosis. …”
Publicado 2019
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1548346por Pinto, Emilia, Figueiredo, Bonald, Galvao, Henrique, Fragoso, Maria, Ribeiro, Enilze, Diekmann, Yoan, Clay, Michael, Pounds, Stanley, Wu, Gang, Nichols, Kim, Ribeiro, Raul, Zambetti, Gerard“…TP53-R337H predisposes children to adrenocortical tumors (ACTs) and adults to various other Li-Fraumeni syndrome (LFS)-associated core cancers. Assessment of the family history of cancer in TP53-R337H carriers has revealed families fulfilling the classic criteria for LFS as well as those showing an apparently sporadic pattern of cancer presentation, suggesting that genetic and/or environmental factors modulate cancer penetrance in TP53-R337H carriers. …”
Publicado 2019
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1548347“…However, a change in HPA axis tone cannot be ruled out. 3) Plasma IC measures of F and E may be more sensitive than urine metabolites for detecting changes associated with T2D. 4) Preventing increased IC-F in T2D may be a potential target for therapeutic intervention.Sources of Research Support: NIH, Endocrine Fellows Foundation, Inter-institutional funding.…”
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1548348por Ranjit, Sanjay“…In conclusion, ERAP1 deficiency is associated with SSBP, likely secondary both to increased ALDO and altered renovascular function.…”
Publicado 2019
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1548349por Wood, Claire, Wong, Jarod Sze Choong, Straub, Volker, Ahmed, S, Farquharson, Colin“…Glucocorticoids (GCs) are associated with many adverse effects including osteoporosis and growth retardation. …”
Publicado 2019
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1548350por Lo, Joan, Ettinger, Bruce, Chandra, Malini, Sanchez, Gabriela, Sam, Danny, Vu, Joseph, Iribarren, Carlos“…Analyses included the distribution of 25OHD level and whether low 25OHD was associated with higher PTH. Sensitivity analyses were conducted excluding those with use of calcium (>3x/week) or vitamin D (>1x/week) supplements because of the potential impact of supplement use on 25OHD level. …”
Publicado 2019
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1548351por Wajnrajch, Michael, Gomez, Roy, Hey-Hadavi, Judith, Kelepouris, Nicky, van der Lans, Joli, Camacho-Hubner, Cecilia, Cara, Jose, Rajicic, Natasa, Rao Valluri, Srinivas, Fleseriu, Maria, Salvatori, Roberto, Brue, Thierry, Ghigo, Ezio, Palladino, Andrew“…Improved IGF-I control was associated with improved symptoms of acromegaly. Importantly, in this large cohort of patients the incidence of pituitary tumor increase and liver test elevations were low, and similar to previously reported rates. …”
Publicado 2019
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1548352por Hakimian, Stephanie, Niznik, Charlotte, El Muayed, Malek, Yee, Lynn, Premkumar, Ashish, Metzger, Boyd, Wallia, Amisha“…Background: Gestational diabetes mellitus (GDM) is defined as “impairment of glucose tolerance with first recognition during pregnancy” and is rarely associated with diabetic ketoacidosis (DKA). The incidence of DKA in pregnancy is about 1-3% in those with type 1 or 2 DM. …”
Publicado 2019
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1548353por Wajnrajch, Michael, Gomez, Roy, Hey-Hadavi, Judith, Kelepouris, Nicky, Lans, Joli, Loftus, Jane, Camacho-Hubner, Cecilia, Cara, Jose, Rao Valluri, Srinivas, Fleseriu, Maria, Salvatori, Roberto, Webb, Susan, Brue, Thierry, Palladino, Andrew“…Improved IGF-I control was associated with improved HbA(1)C, QoL and symptoms of acromegaly. …”
Publicado 2019
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1548354por Faria, Aline, Canton, Ana, Brito, Luciana, Palhares, Heloisa, Seraphim, Carlos, Resende, Elisabete Mantovani, Borges, Maria de Fatima, Latronico, Ana Claudia, Mendonca, Berenice, Brito, Vinicius“…Only one girl in IPT group also presented pubarche (PH3), associated to zinc oxide cream use and none in PPP group presented pubarche. …”
Publicado 2019
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1548355por Jan De Beur, Suzanne, Miller, Paul, Weber, Thomas, Peacock, Munro, Insogna, Karl, Kumar, Rajiv, Luca, Diana, Theodore-Oklota, Christina, Lampl, Kathy, San Martin, Javier, Carpenter, Thomas“…In adults with TIO Syndrome, burosumab was associated with improvements in serum phosphorus, osteomalacia, mobility, quality of life, and reductions in fatigue.…”
Publicado 2019
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1548356por Jain, Puneet, Finger, Paul T., Damato, Bertil, Coupland, Sarah E., Heimann, Heinrich, Kenawy, Nihal, Brouwer, Niels J., Marinkovic, Marina, Van Duinen, Sjoerd G., Caujolle, Jean Pierre, Maschi, Celia, Seregard, Stefan, Pelayes, David, Folgar, Martin, Yousef, Yacoub A., Krema, Hatem, Gallie, Brenda, Calle-Vasquez, AlbertoEnlace del recurso
Publicado 2019
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1548357por Ishimura, Masataka, Eguchi, Katsuhide, Shiraishi, Akira, Sonoda, Motoshi, Azuma, Yoshihiro, Yamamoto, Hiroyuki, Imadome, Ken-ichi, Ohga, Shouichi“…CAEBV is recognized as a poor prognostic disease of EBV-associated T-cell and NK-cell LPD arising from the clonal proliferation of EBV-infected T cells (CD4(+), CD8(+), and TCRγδ(+)) and/or NK cells. …”
Publicado 2019
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1548358por Mateo‐Urdiales, Alberto, Johnson, Samuel, Smith, Rhodine, Nachega, Jean B, Eshun‐Wilson, Ingrid“…Rapid ART initiation was associated with a lower mortality estimate, however the CIs included no effect when compared to standard of care (RR 0.72, 95% CI 0.51 to 1.01; 5451 participants, 7 studies; very low‐certainty evidence). …”
Publicado 2019
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1548359por Caterino, Jeffrey M., Adler, David, Durham, Danielle D., Yeung, Sai-Ching Jim, Hudson, Matthew F., Bastani, Aveh, Bernstein, Steven L., Baugh, Christopher W., Coyne, Christopher J., Grudzen, Corita R., Henning, Daniel J., Klotz, Adam, Madsen, Troy E., Pallin, Daniel J., Reyes-Gibby, Cielito C., Rico, Juan Felipe, Ryan, Richard J., Shapiro, Nathan I., Swor, Robert, Venkat, Arvind, Wilson, Jason, Thomas, Charles R., Bischof, Jason J., Lyman, Gary H.Enlace del recurso
Publicado 2019
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1548360por Loh, Jing Loong Moses, Chan, Stephrene, Wong, Keng Lin, de Mel, Sanjay, Yap, Eng Soo“…In addition, patients with chemoprophylaxis showed an association with higher post-operative outcome scores such as post op 6 months SF36 (PCS), post op 12 months SF36 (PCS), post op 12 months SF36 (MCS), post op 24 months SF36 (MCS) and post op 24 months WOMAC. …”
Publicado 2019
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