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  1. 1548341
    “…High baseline SST2 expression further validated by Western blot and confocal immunofluorescence, imply that SST receptor expression associates with ONO-ST1-641 responsiveness. Available SRLs and GHR antagonists are parenteral, requiring lifelong injection, with variable and suboptimal efficacy, necessitating development of novel oral small molecule drugs for acromegaly. …”
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  2. 1548342
    “…It is reported that tRFs, especially tiRNA-5 associated with stress. However, whether tRFs connect with NAFLD is unclear. …”
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  3. 1548343
    por Vigersky, Robert, McMahon, Chantal
    Publicado 2019
    “…Recent studies have shown that TIR has a similar association with diabetes microvascular complications as does HbA1c (1,2). …”
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  4. 1548344
  5. 1548345
    “…Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity with prevalence rates of 65 - 85% in obese individuals. It can be associated liver cell injury eventually leading to cirrhosis. …”
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  6. 1548346
    “…TP53-R337H predisposes children to adrenocortical tumors (ACTs) and adults to various other Li-Fraumeni syndrome (LFS)-associated core cancers. Assessment of the family history of cancer in TP53-R337H carriers has revealed families fulfilling the classic criteria for LFS as well as those showing an apparently sporadic pattern of cancer presentation, suggesting that genetic and/or environmental factors modulate cancer penetrance in TP53-R337H carriers. …”
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  7. 1548347
    “…However, a change in HPA axis tone cannot be ruled out. 3) Plasma IC measures of F and E may be more sensitive than urine metabolites for detecting changes associated with T2D. 4) Preventing increased IC-F in T2D may be a potential target for therapeutic intervention.Sources of Research Support: NIH, Endocrine Fellows Foundation, Inter-institutional funding.…”
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  8. 1548348
    por Ranjit, Sanjay
    Publicado 2019
    “…In conclusion, ERAP1 deficiency is associated with SSBP, likely secondary both to increased ALDO and altered renovascular function.…”
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  9. 1548349
  10. 1548350
    “…Analyses included the distribution of 25OHD level and whether low 25OHD was associated with higher PTH. Sensitivity analyses were conducted excluding those with use of calcium (>3x/week) or vitamin D (>1x/week) supplements because of the potential impact of supplement use on 25OHD level. …”
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  11. 1548351
    “…Improved IGF-I control was associated with improved symptoms of acromegaly. Importantly, in this large cohort of patients the incidence of pituitary tumor increase and liver test elevations were low, and similar to previously reported rates. …”
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  12. 1548352
    “…Background: Gestational diabetes mellitus (GDM) is defined as “impairment of glucose tolerance with first recognition during pregnancy” and is rarely associated with diabetic ketoacidosis (DKA). The incidence of DKA in pregnancy is about 1-3% in those with type 1 or 2 DM. …”
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  13. 1548353
  14. 1548354
  15. 1548355
    “…In adults with TIO Syndrome, burosumab was associated with improvements in serum phosphorus, osteomalacia, mobility, quality of life, and reductions in fatigue.…”
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  16. 1548356
  17. 1548357
    “…CAEBV is recognized as a poor prognostic disease of EBV-associated T-cell and NK-cell LPD arising from the clonal proliferation of EBV-infected T cells (CD4(+), CD8(+), and TCRγδ(+)) and/or NK cells. …”
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  18. 1548358
    “…Rapid ART initiation was associated with a lower mortality estimate, however the CIs included no effect when compared to standard of care (RR 0.72, 95% CI 0.51 to 1.01; 5451 participants, 7 studies; very low‐certainty evidence). …”
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  19. 1548359
  20. 1548360
    “…In addition, patients with chemoprophylaxis showed an association with higher post-operative outcome scores such as post op 6 months SF36 (PCS), post op 12 months SF36 (PCS), post op 12 months SF36 (MCS), post op 24 months SF36 (MCS) and post op 24 months WOMAC. …”
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