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  1. 1548981
    “…We used gene set enrichment analysis (GSEA) to identify the biological processes associated with these isoform c-regulated genes. We found a pronounced enrichment of gene sets related to apoptosis, activation of DNA damage pathways and cell cycle arrest in response to eviction of nuclear isoform c. …”
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    Nuclear ErbB-2-Induced Transcriptome Drives Triple Negative Breast Cancer Growth
  2. 1548982
    por Dinh, Kathryn, Narla, Radhika Rao
    Publicado 2021
    “…CSC normalized 9/30/2019 and he subsequently received three cycles of pembrolizumab 11/25/2019 to 1/6/2020, discontinued for associated pneumonitis He again developed HCM 6/5/2020 with CSC 12.6 mg/dL. …”
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    Single Dose of Denosumab Effective for Management of Bisphosphonate-Refractory Hypercalcemia of Malignancy Related to Non-Small Cell Lung Cancer
  3. 1548983
    “…ICS exposure was also associated with risk of AI. Participants at high risk AI had a greater adherence to ICS therapy (78% vs 62%, p=0.049) and greater cumulative received ICS dose over the study duration than those at low risk AI (178.2 vs 127.9 mg, p=0.036). …”
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    Prevalence of Suppressed Morning Serum Cortisol and Its Relationship With Cumulative Glucocorticoid Exposure in a Moderate-Severe Asthma Patient Cohort
  4. 1548984
    “…Evidence suggests that elevated circulating levels of fibroblast growth factor 23 (FGF23) are associated with an increase in fat mass and dyslipidemia in elderly normal individuals. …”
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    Serum Levels of Lipocalin Are Lower in Adolescents With X-Linked Hypophosphatemia
  5. 1548985
    “…In these patients, serum creatinine (SCr)-based methods to calculate estimated glomerular filtration rate (eGFR) can lead to inaccurate results. eGFR is reported to be negatively correlated to muscle mass and PWS-associated low lean body mass may contribute to low SCr levels. …”
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    Evaluation of Methods That Estimate Glomerular Filtration Rate in Patients With Prader-Willi Syndrome
  6. 1548986
    “…Implementation of a single virtual consult for severely hyperglycemic hospitalized COVID19 patients was associated with rapidly reduced BG concentrations, especially in the ICU. …”
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    A Single Virtual Consult Reduces Severe Hyperglycemia in Patients Admitted with COVID19 Infection
  7. 1548987
    “…Further research is planned to identify various forms of therapeutic inertia associated with these segments.…”
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    Trajectory of Glycated Hemoglobin Over Time Among Obese Type 2 Diabetes Patients on U-100 Basal-Bolus Insulin Regimen Using Real-World Data
  8. 1548988
    “…Conclusions: In this Phase 3 trial in patients with BBS and AS, setmelanotide was associated with significant body weight and hunger reduction, with responses being greater in individuals with BBS.…”
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    A Phase 3 Trial in Participants With Obesity Due to Bardet-Biedl Syndrome or Alström Syndrome: Efficacy and Safety of the Melanocortin 4 Receptor Agonist Setmelanotide
  9. 1548989
    “…Clinically beneficial weight loss of ≥10% was achieved by over two-thirds of participants and ≥20% by one-third of participants, along with associated improvements in cardiometabolic risk factors and physical functioning.…”
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    Efficacy and Safety of Once-Weekly Subcutaneous Semaglutide 2.4 MG in Adults With Overweight or Obesity (STEP 1)
  10. 1548990
    “…No grade 4-5 adverse event occurred Conclusion: The association of dabrafenib and trametinib in BRAFV600E mutated patients is effective for restoring RAI uptake and is followed by a tumor control in 90% of patients and by tumor response in 38% with limited adverse events. …”
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    MERAIODE: A Redifferentiation Phase II Trial With Trametinib and Dabrafenib Followed by Radioactive Iodine Administration for Metastatic Radioactive Iodine Refractory Differentiated Thyroid Cancer Patients With a BRAFV600E Mutation (NCT 03244956)
  11. 1548991
    “…For diabetes-specific mortality, only MARD (HR 2.2 95% CI: 1.3–3.7) was associated. Conclusion: There is an overall increase in diabetes prevalence and its subgroups from 1999 to 2018; MORD had the highest increase. …”
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    Trends in Diabetes Subgroups and Their Risk for All-Cause, Cardiovascular Disease and Diabetes-Specific Mortality in the US: A Data-Driven Reproducible Machine Learning Approach
  12. 1548992
    “…Our study uniquely examines this association in a largely African American cohort, a population disproportionately affected by COVID-19. …”
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    Sugar Is Not Always Sweet: Exploring the Relationship Between Hyperglycemia and COVID-19 in a Predominantly African American Population
  13. 1548993
    “…African American, compared to Caucasian ethnicity, was significantly associated with MV (OR 1.437; CI= 1.131–1.825; P=0.0009) and ICU admission (OR 1.428; CI= 1.150–1.773; P=0.0002), but not VTE. …”
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    The Relationship Between Age, Gender, Race, Diabetes and Obesity on Clinical Outcomes in a Large Cohort of Patients Hospitalized for Covid-19 in Metropolitan Detroit
  14. 1548994
    “…We previously demonstrated that paternal obesity is associated with offspring metabolic risk during later life, and that paternal SGLT2i treatment improves offspring metabolic phenotypes. …”
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    Paternal Obesity and SGLT2 Inhibition Alter Expression of Placental Regulatory Genes
  15. 1548995
    “…Of the 82 patients with negative anti-TPO at baseline, 16 had significant interval increase in anti-TPO titer by >12 units (2×6 [precision of the anti-TPO assay in normal range being 6 units per SD]), of these, four became anti-TPO positive. Factors associated a significant increase in anti-TPO titer included worse baseline clinical severity (p=0.018), elevated C-reactive protein during hospitalization (p=0.033), and higher baseline anti-TPO titer (p=0.005). …”
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    Insights From Prospective Follow-up of Thyroid Function and Autoimmunity Among Covid-19 Survivors
  16. 1548996
    “…Conclusion: In our cohort, over 97% were Chinese and close to 60% had family history of T2DM, thus fulfilling the ‘high-risk’ group criteria as suggested by American Diabetes Association to have FPG or OGTT screening. Nevertheless, only 18% of subjects had prediabetes or diabetes based on OGTT results. …”
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    Who Should Return for an Oral Glucose Tolerance Test? A Proposed Clinical Pathway Based on Retrospective Analysis of 332 Children
  17. 1548997
    “…Total pancreatectomy with intraportal islet cell autotransplantation (TPIAT) allows for the islets to be isolated and subsequently re-infused to prevent the complications associated with post-pancreatectomy diabetes in patients with chronic or recurrent pancreatitis. …”
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    Comparable Long-Term Glycemic Control and Insulin-Independent Rate at Less Cost By Using Intra-Operative vs. Islet Cell Laboratory Isolation for Total Pancreatectomy With Islet Auto-Transplantation
  18. 1548998
    “…Background: Monoclonal antibody to Programmed cell death-1 (PD-1) protein binds to PD-1 receptor and blocks its interaction with PD Ligand 1 and PD Ligand 2, which helps restore the immune response for various types of cancer treatment are used widely. These agents are associated with many auto immune diseases. We describe a case where a patient treated with PD-1 inhibitor manifested three autoimmune diseases. …”
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    New Onset Autoimmune Diabetes Mellitus, Autoimmune Thyroiditis and Subsequent Autoimmune Hepatitis With Monoclonal Antibody to Programmed Cell Death-1 (PD-1) Protein Therapy in a Patient With Non Small Cell Lung Cancer: 18 Months Follow up Experience
  19. 1548999
    “…Conclusion: Despite the known metabolic association of PCOS and insulin resistance, we found that the risk profiles of PCOS and DM differed by Asian ethnicity, with risk of PCOS highest in South Asian women and risk of DM highest in Filipina women. …”
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    The Risks of Polycystic Ovary Syndrome and Diabetes Vary by Ethnic Subgroup Among Young Asian Women
  20. 1549000
    “…All races/ethnicities had lower odds of adequate muscle-strengthening PA compared to NHWs (aOR [95% CI]: NHB, 0.94 [0.90, 0.99]; AI, 0.68 [0.60, 0.79]; OA, 0.75 [0.68, 0.84]; H/O, 0.73 [0.69, 0.77]). These inverse associations persisted in DM-diagnosed OAs, but not AIs. …”
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    Racial/Ethnic Differences in Leisure-Time Physical Activity Among United States Adults With and Without Diabetes
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