“…Given the substantial morbidity and mortality caused by COVID19-associated coagulopathy, we sought to identify a flavonoid that inhibits both SARS-CoV-2 Mpro and PDI, potentially blocking both viral replication and thrombus formation. …”
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“…Objectives: Describe three cases of COVID-19 associated acquired aplastic anemia in immunocompetent pediatric patients. …”
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“…The incidence of bleeding complications was captured as defined by CCC19 and included both major and non major bleeding . Associated baseline clinic-pathologic prognostic factors and outcomes such as need for mechanical ventilation, intensive care unit (ICU) admission and mortality rates were assessed Results :3849 pts met analysis inclusion criteria. …”
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“…However, administration of cytotoxic chemotherapy without BCDT was not associated with reduced production of antibodies. In fact, almost all patients (94%) who received cytotoxic chemotherapy without BCDT, produced antibodies against spike protein (table 2). …”
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“…A statistically significant association (p<0,05), was observed between higher age and death in both groups. …”
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“…TH2b immunity is related to STAT6, STAT3, GATA2, and GATA3. TH22 immunity is associated with both STAT3α and AHR. THαβ immunity is related to STAT1α, STAT1β, STAT2, STAT3β, and ISGF. …”
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“…Une moyenne de comorbidité associant 5 affections est retrouvée en G1 versus 3 en G2. …”
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“…On a noté, par l’étude univariée, une association entre le NLR et la mortalité (p < 0,001). …”
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“…Après avoir étudié la corrélation entre la présence ou non de la dyspnée avec les valeurs de la SpO(2), nous n’avons pas retrouvé une association significative entre la désaturation (SpO(2) < 93°%) et la dyspnée chez nos malades (OR°: 0,96°; IC95°%°: 0,52–1,76°; p = 0,902). …”
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“…L’étude univariée n’a pas montré d’association entre la persistance d’anomalie scanographique et les comorbidités, l’âge, le rapport neutrophiles sur lymphocytes, la durée de l’oxygénothérapie. …”
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“…Il serait légitime de craindre que l’asthme soit associé aux formes graves du COVID-19. Notre étude montre que l’impact de l’asthme sur l’infection par le SARS-CoV-2 est controversée.…”
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“…CONCLUSION: Une alvéolite lymphocytaire et à PNN parfois associée à une plasmocytose est retrouvée à la phase initiale de la pneumonie COVID-19 en présence d’une PCR+; cette alvéolite s’associe à la présence d’IL6, IL8, IL10, IFNg, TNFa et d’HGF. …”
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“…Tous nos patients avaient bénéficié du protocole thérapeutique adopté par le ministère de santé associant l’hydroxychloroquine et l’azythromycine avec de la corticothérapie et l’oxygénothérapie, 75 % des malades dans le G2 avaient une bonne évolution contre 54 % dans le G1, les patients transférés en réanimation étaient de l’ordre de 34 % dans le G1 et n’était que de 16 % dans le G2, la létalité était de 12 % dans le G1 et de 9 % dans le G2. …”
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“…Importantly, PTX/Aβ-CN-PMs exhibited better anti-glioma effects and tissue distribution profile with rapid accumulation in glioma tissues in vivo and prolonged median survival of glioma-bearing mice compared to those associated with PMs without the ApoE protein corona. …”
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“…Subtype level re-infections were usually associated with low IgG levels for the specific subtype of the acute infection, suggesting only short-time humoral immunity induced by previous infection by this subtype. …”
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“…Furthermore, the Spearman correlation analysis indicated that the microbes prevalent in HS were positively (P < 0.05) associated with intestinal morphological injuries indicators and ileal immune response parameters, and the microbes reduced in HS were negatively (P < 0.05) with the performance data. …”
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“…Key pharmacokinetic parameters included maximum plasma drug concentration (C(max)), plasma trough drug concentration, time to C(max) during a dosing interval (t(max)), area under the concentration–time curve from time 0 to time of last collected sample, area under the concentration–time curve over the dosing interval (24 h) at steady state (AUC(tau,ss)), first-order rate constant associated with the terminal phase of elimination, terminal half-life (t(1/2)), total clearance of drug from plasma after oral administration, and apparent volume of distribution at steady state. …”
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“…Multiple linear regression analysis showed that the frequency of EAFH for breakfast was not associated with BMI (p > 0.05), the frequency of EAFH for lunch was negatively correlated with BMI (β = −0.024, p = 0.008), and the frequency of EAFH for dinner was positively correlated with BMI (β = 0.040, p = 0.004).The frequency of EAFH of male (β = 0.013, p = 0.008), 60 years old and above (β = 0.022, p = 0.021), family per capita annual income less than 10,000 RMB (β = 0.019, p = 0.005), junior high school education or below (β = 0.012, p = 0.009), and unemployed/retired (β = 0.029, p = 0.003) adults were positively correlated with BMI. …”
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