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1551241“…Le taux de mortalité à 1 mois était plus important que celui rapporté dans la population générale, probablement à pondérer par la présence de comorbidités. Les facteurs associés de manière significative à la sévérité de la COVID-19 chez les TP étaient la transplantation pour une BPCO et le traitement par évérolimus. …”
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1551242por Amour, S., Dananché, C., Del Signore, C., Romain-Scelle, N., Bal, A., Morfin, F., Vanhems, P.“…Cela impose d'investiguer les déterminants associés aux formes sévères et aux séjours en réanimation malgré un schéma vaccinal complet, ainsi que les caractéristiques de la COVID19 chez les vaccinés selon les différents vaccins et les souches virales circulantes. …”
Publicado 2022
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1551243“…Pour la vaccination contre la covid-19, les facteurs associés à une meilleure CV sont l'âge (p<0,001), le fait d'avoir été vacciné contre la grippe en 2019/20 (p=0.0027) et en 2020/21 (p=0,004). …”
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1551244por Hudson, Jemma, Cruickshank, Moira, Quinton, Richard, Aucott, Lorna, Aceves-Martins, Magaly, Gillies, Katie, Bhasin, Shalender, Snyder, Peter J, Ellenberg, Susan S, Grossmann, Mathis, Travison, Thomas G, Gianatti, Emily J, van der Schouw, Yvonne T, Emmelot-Vonk, Marielle H, Giltay, Erik J, Hackett, Geoff, Ramachandran, Sudarshan, Svartberg, Johan, Hildreth, Kerry L, Groti Antonic, Kristina, Brock, Gerald B, Tenover, J Lisa, Tan, Hui Meng, Kong, Christopher Ho Chee, Tan, Wei Shen, Marks, Leonard S, Ross, Richard J, Schwartz, Robert S, Manson, Paul, Roberts, Stephen, Andersen, Marianne Skovsager, Magnussen, Line Velling, Hernández, Rodolfo, Oliver, Nick, Wu, Frederick, Dhillo, Waljit S, Bhattacharya, Siladitya, Brazzelli, Miriam, Jayasena, Channa N“…Overall, patient age (interaction 0·97 [99% CI 0·92–1·03]; p=0·17), baseline testosterone (interaction 0·97 [0·82–1·15]; p=0·69), smoking status (interaction 1·68 [0·41–6·88]; p=0.35), or diabetes status (interaction 2·08 [0·89–4·82; p=0·025) were not associated with cardiovascular risk. INTERPRETATION: We found no evidence that testosterone increased short-term to medium-term cardiovascular risks in men with hypogonadism, but there is a paucity of data evaluating its long-term safety. …”
Publicado 2022
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1551245por Jin, Pengfei, Guo, Xiling, Chen, Wei, Ma, Shihua, Pan, Hongxing, Dai, Lianpan, Du, Pan, Wang, Lili, Jin, Lairun, Chen, Yin, Shi, Fengjuan, Liu, Jingxian, Xu, Xiaoyu, Zhang, Yanan, Gao, George F., Chen, Cancan, Feng, Jialu, Li, Jingxin, Zhu, Fengcai“…CONCLUSIONS: Heterologous boosting with ZF2001 following primary vaccination with Convidecia is more immunogenic than a single dose of Convidecia and is not associated with safety concerns. These results support flexibility in cooperating viral vectored and recombinant protein vaccines. …”
Publicado 2022
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1551246por Pommier, Jean David, Gorman, Chris, Crabol, Yoann, Bleakley, Kevin, Sothy, Heng, Santy, Ky, Tran, Huong Thi Thu, Nguyen, Lam Van, Bunnakea, Em, Hlaing, Chaw Su, Aye, Aye Mya Min, Cappelle, Julien, Herrant, Magali, Piola, Patrice, Rosset, Bruno, Chevalier, Veronique, Tarantola, Arnaud, Channa, Mey, Honnorat, Jerome, Pinto, Anne Laure, Rattanavong, Sayaphet, Vongsouvath, Manivanh, Mayxay, Mayfong, Phangmanixay, Sommanikhone, Phongsavath, Khounthavy, Tin, Ommar Swe, Kyaw, Latt Latt, Tin, Htay Htay, Linn, Kyaw, Tran, Thi Mai Hung, Pérot, Philippe, Thuy, Nguyen Thi Thu, Hien, Nguyen, Phan, Phuc Huu, Buchy, Philippe, Dussart, Philippe, Laurent, Denis, Eloit, Marc, Dubot-Pérès, Audrey, Lortholary, Olivier, de Lamballerie, Xavier, Newton, Paul N, Lecuit, Marc“…Using multivariate analyses, we assessed risk factors associated with unfavourable outcomes (ie, severe neurological sequelae and death) at discharge using data from baseline and day 2 after inclusion. …”
Publicado 2022
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1551247por Wong, Carlos King Ho, Lau, Kristy Tsz Kwan, Xiong, Xi, Au, Ivan Chi Ho, Lai, Francisco Tsz Tsun, Wan, Eric Yuk Fai, Chui, Celine Sze Ling, Li, Xue, Chan, Esther Wai Yin, Gao, Le, Cheng, Franco Wing Tak, Tang, Sydney Chi Wai, Wong, Ian Chi Kei“…After the first dose, incidence rates of overall AESIs (IRR = 0.98, 95% CI 0.89–1.08, p = 0.703) and mortality (IRR = 0.96, 95% CI 0.63–1.48, p = 0.868) associated with CoronaVac were generally comparable to those for BNT162b2, except for Bell palsy (IRR = 1.95, 95% CI 1.12–3.41, p = 0.018), anaphylaxis (IRR = 0.34, 95% CI 0.14–0.79, p = 0.012), and sleeping disturbance or disorder (IRR = 0.66, 95% CI 0.49–0.89, p = 0.006). …”
Publicado 2022
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1551248por Ghosh, Chandril Chandan, McVicar, Duncan, Davidson, Gavin, Shannon, Ciaran, Armour, Cherie“…Therefore, in this study, we inquire that if we prevent such human intervention (and thereby their associated biases) and use Artificial Intelligence (A.I.) to form those disorder structures from the data (patient-reported symptoms) directly, then can we come up with homogenous clusters or categories (representing disorders/syndromes: a group of co-occurring symptoms) that are adequately distinguishable from each other for them to be clinically useful. …”
Publicado 2022
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1551249por Nikaido, Takuya, Takatsuna, Hiroshi, Tabata, Shunsuke, Shiosakai, Kazuhito, Nakatani, Taichi, Konno, Shin-ichi“…The addition of mirogabalin to NSAIDs improved peripheral neuropathic pain associated with LSS and raised no new safety concerns. …”
Publicado 2022
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1551250“…Besides positive selection, we have not detected robust signals of gene-trait coevolution or convergent amino acid shifts in the ectodysplasin pathway associated with shared phenotypic traits among aquatic mammals. …”
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1551251por Boakye, Ellen, Osuji, Ngozi, Erhabor, John, Obisesan, Olufunmilayo, Osei, Albert D., Mirbolouk, Mohammadhassan, Stokes, Andrew C., Dzaye, Omar, El Shahawy, Omar, Hirsch, Glenn A., Benjamin, Emelia J., DeFilippis, Andrew P., Robertson, Rose Marie, Bhatnagar, Aruni, Blaha, Michael J.Enlace del recurso
Publicado 2022
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1551252“…There was an increase in maternal satisfaction (k=6, n=4144; OR 1.95 95% CI 1.28 to 2.96) and odds of an intact perineum (k=17, n=59 070; OR 1.48; 95% CI 1.21 to 1.79) with water immersion. Waterbirth was associated with increased odds of cord avulsion (OR 1.94 95% CI 1.30 to 2.88), although the absolute risk remained low (4.3 per 1000 vs 1.3 per 1000). …”
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1551253por Ganley, Theodore, Ellis, Henry, Shimberg, Jilan, Cruz, Aristides, Aoyama, Julien, Fabricant, Peter, Green, Daniel, Johnson, Benjamin, Kushare, Indranil, Lee, R. Jay, McKay, Scott, Milbrandt, Todd, Patel, Neeraj, Rhodes, Jason, Sachleben, Brant, Traver, Jessica, Mistovich, Justin, Schmale, Gregory, Leska, Tomasina, Cook, Danielle, Yen, Yi-Meng, McGurty, Shannon“…Patients categorized as having a poor final anterior lip displacement measurement had a 10.9 degree decrease in their final range of motion compared to patients categorized in the excellent group (β=-10.9; 95% CI=-18.26, -3.47; p=0.004). There were no associations detected between final anterior lip displacement category and laxity. …”
Publicado 2022
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1551254por Carbone, Andrew, Wang, Kevin, Chu, Brennan, Darden, Christon, Shrestha, Nancy, Colvin, Alexis, Anthony, Shawn, Gladstone, James, Tiao, Justin“…Spearman Rank Order Correlation was done for all variables to test for association between expenditure and year to determine trends over time. …”
Publicado 2022
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1551255por Wu, YunDuo, Shen, Wenli, Wang, Qizheng, Cui, Changqiang, Zha, Li, Lu, Yan Jiao, Liu, Rui, Lin, Xiaofei, Zhu, Hongli“…The results of COX regression analysis indicated that the variables that were remarkably associated with death from sepsis in children were CK-MB, elevated cTnI levels, and SOFA score ≥ 2, and serum cTnI and/or CK-MB levels and SOFA score were remarkably higher correlation (r = 0.453, P < 0.05). …”
Publicado 2022
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1551256“…Verification analyses performed on GSE89714 showed the upregulated mRNAs of Chloride Voltage-Gated Channel 7 (CLCN7), N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma (GNPTG), Unk Like Zinc Finger (UNKL), Adenosine Monophosphate Deaminase 2 (AMPD2), GNAI3, WD Repeat Domain 81 (WDR81), and Serpin Family F Member 1 (SERPINF1) and downregulated mRNAs of TATA-Box Binding Protein Associated Factor 12 (TAF12) co-expressed with five crucial lncRNAs. …”
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1551257por Duo, Hong, Li, Yahui, Sun, Yujie, Wei, Liang, Wang, Ziqing, Fang, Fang, Zhong, Yuxin, Huang, Jiao, Luo, Linjie, Peng, Zhiyong, Pan, Huaqin“…Compared with P-AC treatment in COVID-19 patients, patients with T-AC treatment significantly reduced the incidence of venous thromboembolism (RR 0.51, 95% CI, 0.39–0.67, P<0.00001), but it is not associated with arterial thrombosis events (RR 0.97, 95% CI, 0.66–1.42, P = 0.87). …”
Publicado 2022
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1551258por Ruane, Peter T, Garner, Terence, Parsons, Lydia, Babbington, Phoebe A, Wangsaputra, Ivan, Kimber, Susan J, Stevens, Adam, Westwood, Melissa, Brison, Daniel R, Aplin, John D“…Hypernetworks, pathway analysis, random forest machine learning and RNA velocity were employed to identify gene networks associated with implantation. MAIN RESULTS AND THE ROLE OF CHANCE: The majority of embryos co-cultured with Ishikawa cell layers from Day 6 to 8 breached the epithelial layer (37/46), and syncytiotrophoblast was seen in all of these. …”
Publicado 2022
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1551259por Wong, Carlos K H, Au, Ivan C H, Lau, Kristy T K, Lau, Eric H Y, Cowling, Benjamin J, Leung, Gabriel M“…This retrospective cohort study aimed to evaluate the clinical and virological outcomes associated with molnupiravir or nirmatrelvir–ritonavir use in hospitalised patients with mild-to-moderate COVID-19 during a pandemic wave dominated by the omicron BA.2 subvariant. …”
Publicado 2022
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1551260por Kotanidis, Christos P, Xie, Cheng, Alexander, Donna, Rodrigues, Jonathan C L, Burnham, Katie, Mentzer, Alexander, O’Connor, Daniel, Knight, Julian, Siddique, Muhammad, Lockstone, Helen, Thomas, Sheena, Kotronias, Rafail, Oikonomou, Evangelos K, Badi, Ileana, Lyasheva, Maria, Shirodaria, Cheerag, Lumley, Sheila F, Constantinides, Bede, Sanderson, Nicholas, Rodger, Gillian, Chau, Kevin K, Lodge, Archie, Tsakok, Maria, Gleeson, Fergus, Adlam, David, Rao, Praveen, Indrajeet, Das, Deshpande, Aparna, Bajaj, Amrita, Hudson, Benjamin J, Srivastava, Vivek, Farid, Shakil, Krasopoulos, George, Sayeed, Rana, Ho, Ling-Pei, Neubauer, Stefan, Newby, David E, Channon, Keith M, Deanfield, John, Antoniades, Charalambos“…Finally, C19-RS was strongly associated (r=0·61, p=0·00031) with a whole blood transcriptional module representing dysregulation of coagulation and platelet aggregation pathways. …”
Publicado 2022
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