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321por Lee, Jaesung S., Mandell, Edward K., Tucey, Timothy M., Morris, Danna K., Victoria, Lundblad“…Mutagenesis of predicted surface residues was used to generate a functional map of one surface of Est3, which identified a site that mediates association with the telomerase complex. Surprisingly, the predicted OB-fold of Est3 is structurally similar to the OB-fold of the mammalian TPP1 protein, despite the fact that Est3 and TPP1, as components of telomerase and a telomere capping complex, respectively, perform functionally distinct tasks at chromosome ends. …”
Publicado 2008
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322por Aparicio, Tomás, Guillou, Emmanuelle, Coloma, Javier, Montoya, Guillermo, Méndez, Juan“…Using new antibodies that allow the detection of endogenous hGINS in cells and tissues, we have examined its expression, abundance, subcellular localization and association with other DNA replication proteins. Expression of hGINS is restricted to actively proliferating cells. …”
Publicado 2009
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323“…Moreover, leukemia-associated guanine nucleotide exchange factor (LARG) associates with Unc5B to transduce the RhoA signal. …”
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325The More the Worse: the Grade of Noise-Induced Hearing Loss Associates with the Severity of Tinnitus“…To analyze a possible association of the degree of hearing loss with the severity of tinnitus, we have performed a retrospective study using admission data on 531 patients suffering from chronic tinnitus. …”
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327por Khan, Abdul Q, Bury, Jonathan P, Brown, Steven R, Riley, Stuart A, Corfe, Bernard M“…If further validated these findings may suggest the chemopreventive value of butyrate is limited to early stage carcinogenesis as low K8 expression is associated with a poor prognosis.…”
Publicado 2011
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328por Liang, Yanhua“…Furthermore, luciferase-based NFκB reporter assays demonstrated that SHARPIN negatively associates with NFκB activation, which can be partly compensated by over-expression of TRAF2. …”
Publicado 2011
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330por Huveneers, Stephan, Oldenburg, Joppe, Spanjaard, Emma, van der Krogt, Gerard, Grigoriev, Ilya, Akhmanova, Anna, Rehmann, Holger, de Rooij, JohanEnlace del recurso
Publicado 2012
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331“…Our finding indicates that lower blood calcium levels are associated with a higher risk of unfavorable prognosis and bone metastasis of NSCLC.…”
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332por Li, Jian, Harris, R. Alan, Cheung, Sau Wai, Coarfa, Cristian, Jeong, Mira, Goodell, Margaret A., White, Lisa D., Patel, Ankita, Kang, Sung-Hae, Shaw, Chad, Chinault, A. Craig, Gambin, Tomasz, Gambin, Anna, Lupski, James R., Milosavljevic, Aleksandar“…Analysis of copy number variants (CNVs) from 400 human samples identified using a custom-designed array comparative genomic hybridization (aCGH) chip, combined with publicly available structural variation data, indicates that association of structural mutability with germline hypomethylation is comparable in magnitude to the association of structural mutability with LCR–mediated NAHR. …”
Publicado 2012
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334por Kumar, Priyadarsina, Lindberg, Louise, Thirkill, Twanda L., Ji, Jennifer W., Martsching, Lindsay, Douglas, Gordon C.“…While MUC1-N predominantly associated with speckles, MUC1-C was present in the nuclear matrix, nucleoli, and the nuclear periphery. …”
Publicado 2012
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335por Birkeland, E, Wik, E, Mjøs, S, Hoivik, E A, Trovik, J, Werner, H M J, Kusonmano, K, Petersen, K, Raeder, M B, Holst, F, Øyan, A M, Kalland, K-H, Akslen, L A, Simon, R, Krakstad, C, Salvesen, H B“…RESULTS: Amplification and gain of KRAS present in 3% of the primary lesions and 18% of metastatic lesions correlated significantly with poor outcome, high International Federation of Gynaecology and Obstetrics stage, non-endometrioid subtype, high grade, aneuploidy, receptor loss and high KRAS mRNA levels, also found to be associated with aggressive phenotype. In contrast, KRAS mutations were present in 14.7% of primary lesions with no increase in metastatic lesions, and did not influence outcome, but was significantly associated with endometrioid subtype, low grade and obesity. …”
Publicado 2012
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336por Wang, Qun, Zhao, Zong-Bin, Wang, Geng, Hui, Zhen, Wang, Ming-Hua, Pan, Jun-Feng, Zheng, Hong“…To date, a great number of studies have demonstrated that altered expression of kinesins is associated with development and progression of various human cancers. …”
Publicado 2013
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337por Ma, Qilin, An, Xingkai, Li, Zhiming, Zhang, Huanjing, Huang, Wenqing, Cai, Liangliang, Hu, Peng, Lin, Qing, Tzeng, Chi-Meng“…To best of our knowledge, we first screened these variants known to be associated with neurodegeneration disease, E46K (rs104893875) in SNCA, A1442P in LRRK2, IVS9 in PARK2, A350V in SLC41A1, P268S (rs2066842), R702W (rs2066844), G908R (rs2066845), 1007fs (rs2066847) in NOD2 and G2385R (rs34778348) in LRRK2 from southern China population. …”
Publicado 2013
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338por Parets, Sasha E., Conneely, Karen N., Kilaru, Varun, Fortunato, Stephen J., Syed, Tariq Ali, Saade, George, Smith, Alicia K., Menon, Ramkumar“…Additionally, this study replicated the association of several CpG sites associated with gestational age in other studies (CRHBP, PIK3CD and AVP). …”
Publicado 2013
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339por Zhu, Liying, Su, Tingwei, Xu, Min, Xu, Yu, Li, Mian, Wang, Tiange, Sun, Jichao, Zhang, Jie, Xu, Baihui, Lu, Jieli, Bi, Yufang, Wang, Weiqing, Xu, Yiping“…Each 1-standard deviation of increment of eosinophil percentage associated with a 37% decrease of insulin resistance (P = 0.005). …”
Publicado 2013
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340por Atreya, Chloe E, Sangale, Zaina, Xu, Nafei, Matli, Mary R, Tikishvili, Eliso, Welbourn, William, Stone, Steven, Shokat, Kevan M, Warren, Robert S“…Loss of PTEN expression associated with poor survival of CRC patients with liver-only metastases.…”
Publicado 2013
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