Exploring a causal role of DNA methylation in the relationship between maternal vitamin B(12) during pregnancy and child’s IQ at age 8, cognitive performance and educational attain...

por Caramaschi, Doretta, Sharp, Gemma C., Nohr, Ellen A., Berryman, Katie, Lewis, Sarah J., Davey Smith, George, Relton, Caroline L.
Publicado 2017

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

por Mägi, Reedik, Horikoshi, Momoko, Sofer, Tamar, Mahajan, Anubha, Kitajima, Hidetoshi, Franceschini, Nora, McCarthy, Mark I., Morris, Andrew P.
Publicado 2017

Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics

por Strug, Lisa J., Gonska, Tanja, He, Gengming, Keenan, Katherine, Ip, Wan, Boëlle, Pierre-Yves, Lin, Fan, Panjwani, Naim, Gong, Jiafen, Li, Weili, Soave, David, Xiao, Bowei, Tullis, Elizabeth, Rabin, Harvey, Parkins, Michael D., Price, April, Zuberbuhler, Peter C., Corvol, Harriet, Ratjen, Felix, Sun, Lei, Bear, Christine E., Rommens, Johanna M.
Publicado 2016

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle

por Ren, Meixia, Ng, Fu Liang, Warren, Helen R, Witkowska, Kate, Baron, Michael, Jia, Zhilong, Cabrera, Claudia, Zhang, Ruoxin, Mifsud, Borbala, Munroe, Patricia B, Xiao, Qingzhong, Townsend-Nicholson, Andrea, Hobbs, Adrian J, Ye, Shu, Caulfield, Mark J
Publicado 2018

Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

por Viñuela, Ana, Brown, Andrew A, Buil, Alfonso, Tsai, Pei-Chien, Davies, Matthew N, Bell, Jordana T, Dermitzakis, Emmanouil T, Spector, Timothy D, Small, Kerrin S
Publicado 2018

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

por Hackinger, Sophie, Trajanoska, Katerina, Styrkarsdottir, Unnur, Zengini, Eleni, Steinberg, Julia, Ritchie, Graham R.S., Hatzikotoulas, Konstantinos, Gilly, Arthur, Evangelou, Evangelos, Kemp, John P., Evans, David, Ingvarsson, Thorvaldur, Jonsson, Helgi, Thorsteinsdottir, Unnur, Stefansson, Kari, McCaskie, Andrew W., Brooks, Roger A., Wilkinson, Jeremy M., Rivadeneira, Fernando, Zeggini, Eleftheria
Publicado 2017

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression

por Nedeljkovic, Ivana, Lahousse, Lies, Carnero-Montoro, Elena, Faiz, Alen, Vonk, Judith M, de Jong, Kim, van der Plaat, Diana A, van Diemen, Cleo C, van den Berge, Maarten, Obeidat, Ma’en, Bossé, Yohan, Nickle, David C, Consortium, B I O S, Uitterlinden, Andre G, van Meurs, Joyce B J, Stricker, Bruno H C, Brusselle, Guy G, Postma, Dirkje S, Boezen, H Marike, van Duijn, Cornelia M, Amin, Najaf
Publicado 2018

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

por Zaghlool, Shaza B, Mook-Kanamori, Dennis O, Kader, Sara, Stephan, Nisha, Halama, Anna, Engelke, Rudolf, Sarwath, Hina, Al-Dous, Eman K, Mohamoud, Yasmin A, Roemisch-Margl, Werner, Adamski, Jerzy, Kastenmüller, Gabi, Friedrich, Nele, Visconti, Alessia, Tsai, Pei-Chien, Spector, Tim, Bell, Jordana T, Falchi, Mario, Wahl, Annika, Waldenberger, Melanie, Peters, Annette, Gieger, Christian, Pezer, Marija, Lauc, Gordan, Graumann, Johannes, Malek, Joel A, Suhre, Karsten
Publicado 2018

Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling

por Dand, Nick, Mucha, Sören, Tsoi, Lam C, Mahil, Satveer K, Stuart, Philip E, Arnold, Andreas, Baurecht, Hansjörg, Burden, A David, Callis Duffin, Kristina, Chandran, Vinod, Curtis, Charles J, Das, Sayantan, Ellinghaus, David, Ellinghaus, Eva, Enerback, Charlotta, Esko, Tõnu, Gladman, Dafna D, Griffiths, Christopher E M, Gudjonsson, Johann E, Hoffman, Per, Homuth, Georg, Hüffmeier, Ulrike, Krueger, Gerald G, Laudes, Matthias, Lee, Sang Hyuck, Lieb, Wolfgang, Lim, Henry W, Löhr, Sabine, Mrowietz, Ulrich, Müller-Nurayid, Martina, Nöthen, Markus, Peters, Annette, Rahman, Proton, Reis, André, Reynolds, Nick J, Rodriguez, Elke, Schmidt, Carsten O, Spain, Sarah L, Strauch, Konstantin, Tejasvi, Trilokraj, Voorhees, John J, Warren, Richard B, Weichenthal, Michael, Weidinger, Stephan, Zawistowski, Matthew, Nair, Rajan P, Capon, Francesca, Smith, Catherine H, Trembath, Richard C, Abecasis, Goncalo R, Elder, James T, Franke, Andre, Simpson, Michael A, Barker, Jonathan N
Publicado 2017

GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians

por Nongmaithem, Suraj S., Joglekar, Charudatta V., Krishnaveni, Ghattu V., Sahariah, Sirazul A., Ahmad, Meraj, Ramachandran, Swetha, Gandhi, Meera, Chopra, Harsha, Pandit, Anand, Potdar, Ramesh D., H.D. Fall, Caroline, Yajnik, Chittaranjan S., Chandak, Giriraj R.
Publicado 2017

Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease

por Gallone, Giuseppe, Haerty, Wilfried, Disanto, Giulio, Ramagopalan, Sreeram V., Ponting, Chris P., Berlanga-Taylor, Antonio J.
Publicado 2017

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

por Beaumont, Robin N, Warrington, Nicole M, Cavadino, Alana, Tyrrell, Jessica, Nodzenski, Michael, Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Richmond, Rebecca C, Paternoster, Lavinia, Bradfield, Jonathan P, Kreiner-Møller, Eskil, Huikari, Ville, Metrustry, Sarah, Lunetta, Kathryn L, Painter, Jodie N, Hottenga, Jouke-Jan, Allard, Catherine, Barton, Sheila J, Espinosa, Ana, Marsh, Julie A, Potter, Catherine, Zhang, Ge, Ang, Wei, Berry, Diane J, Bouchard, Luigi, Das, Shikta, Hakonarson, Hakon, Heikkinen, Jani, Helgeland, Øyvind, Hocher, Berthold, Hofman, Albert, Inskip, Hazel M, Jones, Samuel E, Kogevinas, Manolis, Lind, Penelope A, Marullo, Letizia, Medland, Sarah E, Murray, Anna, Murray, Jeffrey C, Njølstad, Pål R, Nohr, Ellen A, Reichetzeder, Christoph, Ring, Susan M, Ruth, Katherine S, Santa-Marina, Loreto, Scholtens, Denise M, Sebert, Sylvain, Sengpiel, Verena, Tuke, Marcus A, Vaudel, Marc, Weedon, Michael N, Willemsen, Gonneke, Wood, Andrew R, Yaghootkar, Hanieh, Muglia, Louis J, Bartels, Meike, Relton, Caroline L, Pennell, Craig E, Chatzi, Leda, Estivill, Xavier, Holloway, John W, Boomsma, Dorret I, Montgomery, Grant W, Murabito, Joanne M, Spector, Tim D, Power, Christine, Järvelin, Marjo-Ritta, Bisgaard, Hans, Grant, Struan F A, Sørensen, Thorkild I A, Jaddoe, Vincent W, Jacobsson, Bo, Melbye, Mads, McCarthy, Mark I, Hattersley, Andrew T, Hayes, M Geoffrey, Frayling, Timothy M, Hivert, Marie-France, Felix, Janine F, Hyppönen, Elina, Lowe, William L, Evans, David M, Lawlor, Debbie A, Feenstra, Bjarke, Freathy, Rachel M
Publicado 2018

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair

por Liu, Fan, Chen, Yan, Zhu, Gu, Hysi, Pirro G, Wu, Sijie, Adhikari, Kaustubh, Breslin, Krystal, Pośpiech, Ewelina, Hamer, Merel A, Peng, Fuduan, Muralidharan, Charanya, Acuna-Alonzo, Victor, Canizales-Quinteros, Samuel, Bedoya, Gabriel, Gallo, Carla, Poletti, Giovanni, Rothhammer, Francisco, Bortolini, Maria Catira, Gonzalez-Jose, Rolando, Zeng, Changqing, Xu, Shuhua, Jin, Li, Uitterlinden, André G, Ikram, M Arfan, van Duijn, Cornelia M, Nijsten, Tamar, Walsh, Susan, Branicki, Wojciech, Wang, Sijia, Ruiz-Linares, Andrés, Spector, Timothy D, Martin, Nicholas G, Medland, Sarah E, Kayser, Manfred
Publicado 2018

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

por Warrington, Nicole M, Shevroja, Enisa, Hemani, Gibran, Hysi, Pirro G, Jiang, Yunxuan, Auton, Adam, Boer, Cindy G, Mangino, Massimo, Wang, Carol A, Kemp, John P, McMahon, George, Medina-Gomez, Carolina, Hickey, Martha, Trajanoska, Katerina, Wolke, Dieter, Ikram, M Arfan, Montgomery, Grant W, Felix, Janine F, Wright, Margaret J, Mackey, David A, Jaddoe, Vincent W, Martin, Nicholas G, Tung, Joyce Y, Davey Smith, George, Pennell, Craig E, Spector, Tim D, van Meurs, Joyce, Rivadeneira, Fernando, Medland, Sarah E, Evans, David M
Publicado 2018

Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies

por Lawn, Rebecca B, Anderson, Emma L, Suderman, Matthew, Simpkin, Andrew J, Gaunt, Tom R, Teschendorff, Andrew E, Widschwendter, Martin, Hardy, Rebecca, Kuh, Diana, Relton, Caroline L, Howe, Laura D
Publicado 2018

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects

por Sliz, Eeva, Sebert, Sylvain, Würtz, Peter, Kangas, Antti J, Soininen, Pasi, Lehtimäki, Terho, Kähönen, Mika, Viikari, Jorma, Männikkö, Minna, Ala-Korpela, Mika, Raitakari, Olli T, Kettunen, Johannes
Publicado 2018

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

por Cuellar Partida, Gabriel, Laurin, Charles, Ring, Susan M, Gaunt, Tom R, McRae, Allan F, Visscher, Peter M, Montgomery, Grant W, Martin, Nicholas G, Hemani, Gibran, Suderman, Matthew, Relton, Caroline L, Davey Smith, George, Evans, David M
Publicado 2018

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes

por Vogel, Heike, Kamitz, Anne, Hallahan, Nicole, Lebek, Sandra, Schallschmidt, Tanja, Jonas, Wenke, Jähnert, Markus, Gottmann, Pascal, Zellner, Lisa, Kanzleiter, Timo, Damen, Mareike, Altenhofen, Delsi, Burkhardt, Ralph, Renner, Simone, Dahlhoff, Maik, Wolf, Eckhard, Müller, Timo D, Blüher, Matthias, Joost, Hans-Georg, Chadt, Alexandra, Al-Hasani, Hadi, Schürmann, Annette
Publicado 2018

Consortium-based genome-wide meta-analysis for childhood dental caries traits

por Haworth, Simon, Shungin, Dmitry, van der Tas, Justin T, Vucic, Strahinja, Medina-Gomez, Carolina, Yakimov, Victor, Feenstra, Bjarke, Shaffer, John R, Lee, Myoung Keun, Standl, Marie, Thiering, Elisabeth, Wang, Carol, Bønnelykke, Klaus, Waage, Johannes, Jessen, Leon Eyrich, Nørrisgaard, Pia Elisabeth, Joro, Raimo, Seppälä, Ilkka, Raitakari, Olli, Dudding, Tom, Grgic, Olja, Ongkosuwito, Edwin, Vierola, Anu, Eloranta, Aino-Maija, West, Nicola X, Thomas, Steven J, McNeil, Daniel W, Levy, Steven M, Slayton, Rebecca, Nohr, Ellen A, Lehtimäki, Terho, Lakka, Timo, Bisgaard, Hans, Pennell, Craig, Kühnisch, Jan, Marazita, Mary L, Melbye, Mads, Geller, Frank, Rivadeneira, Fernando, Wolvius, Eppo B, Franks, Paul W, Johansson, Ingegerd, Timpson, Nicholas J
Publicado 2018

Motor performance in early life and participation in leisure‐time physical activity up to age 68 years

por Elhakeem, Ahmed, Hardy, Rebecca, Bann, David, Kuh, Diana, Cooper, Rachel
Publicado 2018