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Mostrando 321 - 340 Resultados de 103,100 Para Buscar '"The Broads"', tiempo de consulta: 0.38s Limitar resultados
  1. 321
    “…This work provides proof of concept that it is possible to identify broad-spectrum inhibitors by iterative phenotypic screenings, and that inhibition of host-pathways critical for viral life cycles can be an effective antiviral strategy.…”
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    Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry
  2. 322
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    Preparation of Copolymer-Based Nanoparticles with Broad-Spectrum Antimicrobial Activity
  3. 323
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    A polyvalent coral snake antivenom with broad neutralization capacity
  4. 324
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    Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
  5. 325
    “…After the withdrawal of highly suspected broad-spectrum antibiotic, Meropenem®, disturbed vitamin K related coagulation factors gradually restored to their optimal levels so as to maintain normal coagulation status. …”
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    Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients
  6. 326
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    Broad phylogeny and functionality of cellulosomal components in the bovine rumen microbiome
  7. 327
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    Incorporating fine‐scale environmental heterogeneity into broad‐extent models
  8. 328
    “…We prioritized 10 of 186 phylogenetically conserved chokepoint enzymes and undertook a target class repurposing approach to test and identify new small molecules with broad spectrum anthelmintic activity. First, we identified and tested 94 commercially available compounds using an in vitro phenotypic assay, and discovered 11 hits that inhibited nematode motility. …”
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    Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics
  9. 329
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    Elimination of onchocerciasis in Africa by 2025: the need for a broad perspective
  10. 330
    por Mazzon, Michela, Marsh, Mark
    Publicado 2019
    “…Here we consider a number of these approaches and their broad-spectrum potential.…”
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    Targeting viral entry as a strategy for broad-spectrum antivirals
  11. 331
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    Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
  12. 332
    “…A major aim of HIV vaccines is the induction of long-lasting, broadly neutralizing antibodies (bnAbs) that can confer sterile immunity for a prolonged period of time. …”
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    Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV
  13. 333
    “…We explored the use of broad-scale informed consent within the Clinical Translational Science Award (CTSA) Program Network. …”
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    Broad-scale informed consent: A survey of the CTSA landscape
  14. 334
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    Broad regulation of gene isoform expression by Wnt signaling in cancer
  15. 335
    “…We found that HAT inhibitors impact certain broad domains of pancreatic cancer cells. Overall, our results reveal potential roles for broad domains in cells from distinct PDAC grades and demonstrate the plasticity of particular broad epigenomic domains to epigenetic inhibitors.…”
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    Disruption of Broad Epigenetic Domains in PDAC Cells by HAT Inhibitors
  16. 336
    por Liu, Yubin, Cao, Wei, Sun, Ming, Li, Taisheng
    Publicado 2020
    “…Combination antiretroviral therapy (cART) is effective but not curative, and no successful vaccine is currently available for human immunodeficiency virus-1 (HIV-1). Broadly neutralizing antibodies (bNAbs) provide a new approach to HIV-1 prevention and treatment, and these promising candidates advancing into clinical trials have shown certain efficacies in infected individuals. …”
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    Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities
  17. 337
    “…Despite decades of scientific effort, there is still no consensus on the determinants of broad-scale gradients of animal diversity. We argue that general drivers of diversity are unlikely to be found among the narrowly defined taxa which are typically analyzed in studies of broad-scale diversity gradients because ecological niches evolve largely conservatively. …”
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    Increasing the phylogenetic coverage for understanding broad-scale diversity gradients
  18. 338
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    Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae
  19. 339
    “…To address this question, we analysed the structural and genetic basis for their engagement and maturation into broadly neutralizing antibodies. Here we show that the germline-encoded precursors of these antibodies act as functional B-cell antigen receptors (BCRs) that initiate subsequent affinity maturation. …”
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    Structural and genetic basis for development of broadly neutralizing influenza antibodies
  20. 340
    “…Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (−)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). …”
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    Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
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