“…Technically, warm dissection was proceeded in majority of cases (98,0%), the graft implantation was performed by this technique with mean cold ischemia time (CIT) of 190,0 ± 100,5 min and WIT of 74,0 ± 39,2 s. …”
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“…The asymmetric unit of the title compound, [Co(C(12)H(8)N(2))(2)(H(2)O)(2)](2)[Ge(C(6)H(5)O(7))(2)](NO(3))(2), features two complex [(C(12)H(8)N(2))(2)(H(2)O)(2)Co](2+) cations, two NO(3) (−) anions as well as one centrosymmetric [(C(6)H(5)O(7))(2)Ge](2−) anion. Two HCit ligands (Cit = citrate, C(6)H(4)O(7)) each coordinate via three different oxygen atoms (hy­droxy­late, α-carboxyl­ate, β-carboxyl­ate) to the Ge atom, forming a slightly distorted octa­hedron. …”
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“…A 63-year-old male patient with an advanced stage EML4-ALK fused pulmonary adenocarcinoma was initially successfully treated with the second-generation ALK inhibitor alectinib and upon progressions subsequently with brigatinib, lorlatinib and chemoimmunotherapy (CIT). Progress to alectinib was associated with a so far undescribed ALK mutation (p.A1200_G1201delinsW) which was, however, tractable by brigatinib. …”
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“…Meanwhile, TREM1 inhibitory peptide decreased neuroinflammation (evidenced by the decreased levels of markers including IL-6, IL-1β, TNF-α) by attenuating proinflammatory subtype transition of microglia (evidenced by the decreased levels of markers including CD68, CD16, CD86) and decreasing the formation of neutrophil extracellular traps (evidenced by the decreased levels of markers including CitH3, MPO, and NE). Further mechanistic study identified that TREM1 can activate downstream proinflammatory pathways through interacting with spleen tyrosine kinase (SYK). …”
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“…Regarding the associated leukocyte infiltration, we found increased numbers of neutrophils (MPO(+) cells), NETs (MPO(+)/CitH3(+)/DAPI(+)), and macrophages (CD68(+) cells) in SV-129 mice, whereas macrophage polarization (MRC1(-) vs. …”
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“…Additional antimicrobial resistance genes, including plasmid-mediated AmpC (CIT and DHA), bla(NDM-5), mcr-3, mph(A) and aac(6′)-Ib-cr, were detected in these isolates. …”
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“…Interestingly, among these targets, 17 genes were categorized as related to the “cell cycle” based on Gene Ontology (GO) classification, namely CENPA, CIT, CCNE1, CCNE2, TIMELESS, BUB1, MCM4, HELLS, SKA3, CDCA2, FANCD2, NUF2, E2F2, SUV39H2, CASC5, ZWILCH and CKAP2). …”
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“…Although the volume of thrombi was comparable between the two groups, fibrin(ogen)-positive areas were significantly increased in defeated mice, in which Ly-6G-positive cells were appreciably co-localized with Cit-H3-positive staining. Treatment with DNase I completely diminished exaggerated fibrin-rich clot formation in defeated mice. …”
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“…PNAs were similarly increased in pre-T1D and T1D-onset NOD isolated islets/insulitis, and immunofluorescence staining revealed increased islet-associated neutrophil extracellular trap (NET) products (myeloperoxidase [MPO] and citrullinated histones [CitH3]) in NOD pancreata. In vitro, cell-free histones and NETs induced islet cell damage, which was prevented by the small polyanionic drug methyl cellobiose sulfate (mCBS) that binds to histones and neutralizes their pathological effects. …”
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“…In vitro, C3a primed neutrophils to form NETs, reflected by amorphous extracellular DNA structures that colocalized with CitH3 and MPO. These data reveal that C3 deficiency can ameliorate AKI by reducing the infiltration of neutrophils and the formation of NETs. …”
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“…After the baseline trial (first visit), in a double-blind, randomised design, 15 trained/developmental (5 females) swimmers and triathletes were assigned to three groups and underwent an 8-day supplementation period, with a daily dose of either 8 gr L-arginine (Arg, n = 5) or L-citrulline (Cit, n = 5) or placebo (Pla, n = 5). On day 9, participants completed experimental trial (second visit). …”
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“…The present study aimed to evaluate the untargeted metabolomics perturbations of Salmonella enterica serovar Enteritidis that has been previously exposed to the sublethal doses of the major components of essential oils: cinnamaldehyde, citral, and linalool (CIN, CIT, and LIN, respectively). Cinnamaldehyde appeared to be the most efficient compound in the assays evaluating the inhibitory effects [0.06% (v/v) as MBC]. …”
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“…However, ESBL genes (bla(CTXM-1), bla(CTX-M-2), bla(TEM-1), and bla(SHV)) and AmpC genes (bla(CIT), bla(ACC), and bla(EBC)) were found in 38 and 16 isolates, respectively. …”
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“…Potential prognostic (TSPYL2, JAKMIP1, CIT, TMTC1) and two diagnostic (MINK1, PLEKHM3) biomarkers were downregulated in GBM. …”
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“…Other well-known neuroprotective pharmacological tools, including memantine (Mem), citicoline (Cit), and ginkgolic acid (GA), were used to compare the potential mechanisms of Cur. …”
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“…The multiplex ELISA using antibodies detecting myeloperoxidase (MPO), citrullinated histone H3 (CitH3) and DNA provided reliable detection of NETs in plasma samples from SLE patients and healthy donors that carry IRF5 genetic risk. …”
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“…The experimental results illustrated that HXTLF mediated the expression levels of H3Cit and myeloperoxidase (MPO) protein in neutrophils activated by LPS, inhibited NETs formation, and reduced the concentration of interleukin- (IL-) 1β, a proinflammatory factor in cells. …”
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“…To analyze the results, 3 software, SciMAT-v1.1.04, VOSviewer-v1.6.14, CitNetExplorer_v1.0.0, were used. Results: Our results showed that most scientific productions in this field fall into 2 categories: (1) effective methods of organizing information and (2) application and operation of the IR system in the process of intelligent questioning and answering, and analyzing information behaviors of physicians and health professionals. …”
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“…Statistically significant (p < 0.05) drops in oPMN counts and the activation states of the CD11b, CD16, CD18, CD64 and H3Cit markers from pre-RT to post-RT were observed. …”
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“…TSPO and DAT PET imaging revealed the increased uptake of (18)F-DPA-714 in substantia nigra and decreased uptake of (18)F-FP-CIT in substantia nigra and striatum in LPS-treated rats (P < 0.001). …”
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