“…Successful behavioral change was characterized by transfer of commitment to a new structure in everyday life, which also honored the request for autonomy. …”
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“…ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progenitor unique to embryonic life. …”
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“…When considering osteogenesis, developments have been made with regards to chemical induction (e.g. differentiation media) and physical induction (e.g. material stiffness, nanotopography), targeting established early transcription factors or regulators such as runx2 or bone morphogenic proteins and promoting increased numbers of cells committing to osteo-specific differentiation. Recent research highlighted the involvement of microRNAs in lineage commitment and terminal differentiation. …”
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“…The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2 (encoded by Ptpn11) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using “Cre-loxP”-mediated gene excision. …”
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“…Here we show that, in human, the first lineage restriction events occur within the CD19(−)CD34(+)CD38(−)CD45RA(−)CD49f(+)CD90(+) (49f(+)) HSC compartment to generate myelo-lymphoid committed cells with no erythroid differentiation capacity. …”
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“…Ex vivo culture experiments demonstrate that these cells are not yet committed to plasma cell differentiation but that they may be sensitized to go down that route. …”
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“…The study investigated eye-movement differences among three groups: a guilty group who took part in a mock crime, an innocent-aware group who did not commit a mock crime but were exposed to the crime stimuli, and an innocent-unaware group who neither committed a mock crime nor had crime-relevant information. …”
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“…Such a field requires sustained funding and commitment from publishers and research funders, who both have a commitment to uphold the integrity of the published scholarly record. …”
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“…RESULTS: Data analysis showed that there is a significant and positive relationship between religious orientation and sexual satisfaction and marital satisfaction. Religious commitment has a predictive role in promoting sexual satisfaction and marital satisfaction, with increasing religious commitment, increasing sexual satisfaction, and marital satisfaction. …”
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“…Moreover, employee-perceived high-performance work systems can enhance employees’ thriving at work through commitment-focused HR attributions (well-being and performance). …”
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“…The formulation was used to systematically investigate factors inducing the efficient commitment to cardiac mesoderm of three hPSC lines. …”
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“…Differential drug responses of the primitive and committed subtype are validated in an independent AML cohort. …”
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“…BACKGROUND: This is an ecological study that analyzes suicides committed in Montenegro during the 2000–2018 period, taking into account gender, age and methods of suicide. …”
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“…To test the link between these identities, two trivariate Cross-Lagged Panel Models were ran, one examining identity exploration and the other examining identity commitment. The results revealed robust within time positive links between ethnic, national and personal identities for both exploration and commitment at all three time-points. …”
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“…Based on the results, it is suggested that the person–organization fit and person–job fit are both crucial factors affecting employees' job satisfaction and organizational commitment, which, in turn, increase employees' willingness to innovate in their jobs and reduce their turnover intentions. …”
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“…Given the cytoskeleton’s role in determining the mechanical properties of adherent cells, the mechanical characterization of stem cells could thus be a potential tool to assess cellular commitment at much earlier time points. In this study, we measured the mechanical properties of hMSCs cultured on soft gelatin-based hydrogels at multiple time points after differentiation induction toward adipogenic or osteogenic lineages. …”
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“…It would seem to be completely forgotten however, between 2000 and 2020, the number of intentional ingestions and murders committed with sodium azide significantly increased. …”
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“…However, uptake of the PF required a significant investment of time and commitment from public health teams at a time when resources were stretched. …”
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“…In the course of the disease 50% of patients with frontotemporal dementia and 10% of patients with Alzheimer’s disease commit crimes. The neurobiological origin of delinquency in dementia is poorly understood. …”
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“…The adipogenic program is accomplished through two sequential phases; the first includes events favoring the commitment of adipose tissue stem cells/precursors to preadipocytes, while the second involves mechanisms that allow the achievement of full adipocyte differentiation. …”
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