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  1. 5441
    “…Using the cre-LoxP system we inactivated the Apc locus via Foxj1-cre, which is expressed in cells committed to ciliated cell lineage. We then characterized the consequent phenotype in two select tissues that bear motile cilia, the lung and the testis. …”
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    Tissue-Dependent Consequences of Apc Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling
  2. 5442
    “…A decrease in the lineage commitment of multipotent Mesenchymal stem cells (MSC) to the bone forming osteoblast lineage and an increase in the commitment to the fat forming adipocyte lineage is more common in bone marrow of elderly persons. …”
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    Impaired of a non-DNA dependent methylation status decides the fat decision of bone marrow-derived C3H10T1/2 stem cell
  3. 5443
    “…The boost of milk-mediated miR may induce pivotal immunoregulatory and epigenetic modifications required for long-term thymic Treg lineage commitment explaining the atopy-protective effect of raw cow’s milk consumption. …”
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    Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
  4. 5444
    “…The minor BCR-ABL1 fusion was detected not only in the CD34(+)CD19(+) population but also in HSPCs and granulocytes, indicating that the Philadelphia chromosome was acquired in an early hematopoietic stage at least prior to the commitment to B cell development. Upon dasatinib treatment, the minor BCR-ABL1 transcript rapidly disappeared in HSPCs but persisted in the CD34(+)CD19(+) population. …”
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    A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation
  5. 5445
    por Lexchin, Joel, Gagnon, Marc-André
    Publicado 2014
    “…The Canadian government committed to compensating provinces for the rise in costs for their public drug plans. …”
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    CETA and pharmaceuticals: impact of the trade agreement between Europe and Canada on the costs of prescription drugs
  6. 5446
    “…Many reports indicate that the Notch pathway regulates muscle regeneration and satellite cell commitment. However, little is known about Notch-mediated effects on other resident myogenic cells. …”
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    Notch signaling regulates myogenic regenerative capacity of murine and human mesoangioblasts
  7. 5447
    “…The basic helix-loop-helix transcription factor, NEUROG3, is critical in causing endocrine commitment from a progenitor cell population in the developing pancreas. …”
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    The window period of NEUROGENIN3 during human gestation
  8. 5448
    “…Activated satellite cells generate a transient amplifying progenitor pool of myoblasts that commit to differentiation and fuse into multinucleated myotubes. …”
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    Wnt/β-catenin controls follistatin signalling to regulate satellite cell myogenic potential
  9. 5449
    “…CONCLUSIONS: Block coordinator’s motivation and commitment affects quality of block organization and student`s success. …”
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    Effect of course coordinator behavior and motivation on students’ achievement: Results from five curriculum blocks of two undergraduate student cohorts at King Saud bin Abdulaziz University of Health Sciences
  10. 5450
    “…Such synthetic matrices that intrinsically support osteogenic commitment of hESCs are not only beneficial for bone tissue engineering but can also be used as a platform to study the effect of the physical and chemical cues to the extracellular milieu on stem cell commitment. …”
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    Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices
  11. 5451
    “…We have recently shown that hES cells under replication stress fail to activate checkpoint kinase 1 (CHK1). They instead commit to apoptosis, which appears to be a primary defense mechanism against genomic instability. …”
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    Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress
  12. 5452
    “…However, it is possible to recognize a common pathogenic commitment of inflammation in atherosclerosis and diabetes, in which metabolic control may also have a role. …”
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    Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients
  13. 5453
    “…This success could not have occurred without exceptional national commitment.…”
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    Increasing Coverage of Hepatitis B Vaccination in China: A Systematic Review of Interventions and Implementation Experiences
  14. 5454
    “…We conclude that p120ctn is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment.…”
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    p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification
  15. 5455
    “…Targeting TAGLN is a plausible approach to enrich for committed hMSC cells needed for regenerative medicine application.…”
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    Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization
  16. 5456
    “…Our data demonstrates that PSC-MSCs have potent capacity to undergo neural differentiation and also implicate the important role of the cytoskeleton in neural lineage commitment.…”
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    Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement
  17. 5457
    “…The implications of such a commitment need further attention.…”
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    We need to talk about purpose: a critical interpretive synthesis of health and social care professionals’ approaches to self‐management support for people with long‐term conditions
  18. 5458
    “…One-third of those in attendance were early career investigators, which reflects a firm commitment to emerging researchers and ultimately to the goal of developing a sustainable scientific enterprise well into the future. …”
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    HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights
  19. 5459
    “…Through this process, the value of committed faculty, the importance of engaging learners in the evaluation of an education program, and the need to implement curriculum that has been carefully evaluated and evidence-informed in nature has emerged. …”
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    Application of the Intervention Mapping Framework to Develop an Integrated Twenty-first Century Core Curriculum—Part Three: Curriculum Implementation and Evaluation
  20. 5460
    “…Having too many allies can, however, lead to policy fragmentation, especially when there is commitment from the highest echelons within each country.…”
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    The G7 presidency and universal health coverage, Japan’s contribution
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