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  1. 11661
    “…Here, we report the use of CRISPR/Cas9 to precisely knock out the committed diterpene synthase gene (SmCPS1) involved in tanshinone biosynthesis in Salvia miltiorrhiza, a traditional Chinese medicinal herb with significant pharmacological activities, such as vasorelaxation, protection against ischemia-reperfusion injury, and antiarrhythmic effects. …”
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    Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza
  2. 11662
    “…Histological and micro-CT results showed that PLGA scaffolds seeded with ESW-treated BMSCs produced more bone-like tissue with commitment to the osteogenic lineage when subcutaneously implanted in vivo, as compared to control group. …”
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    An Innovative Approach for Enhancing Bone Defect Healing Using PLGA Scaffolds Seeded with Extracorporeal-shock-wave-treated Bone Marrow Mesenchymal Stem Cells (BMSCs)
  3. 11663
    “…Upon addition of glucose, cells with a defect in trehalose 6-phosphate synthase (Tps1), the first committed step in the trehalose pathway, display what we have termed an imbalanced glycolytic state; in this state the flux through the upper part of glycolysis outpaces that through the lower part of glycolysis. …”
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    Fatal attraction in glycolysis: how Saccharomyces cerevisiae manages sudden transitions to high glucose
  4. 11664
    “…Notch is indispensable for T cell lineage commitment, and is needed for thymocyte differentiation at early phases. …”
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    c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells
  5. 11665
    “…RESULTS: There were significant differences between groups in relationship satisfaction [F(2, 252) = 3.69, p = .026], intimacy [F(2, 252) = 7.95, p = <.001], and commitment [F(2, 252) = 5.30, p = .006]. Post-hoc analyses revealed additional differences in relationship satisfaction [t(174) = 2.13, p = .035] and intimacy [t(174) = 2.76, p = .006] based on the frequency of SEM use. …”
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    The effects of sexually explicit material use on romantic relationship dynamics
  6. 11666
    “…The Southampton Initiative for Health demonstrates that developing sustainable; workable interventions and effective community partnerships; requires commitment beginning long before intervention delivery but is key to the translation of developmental origins research into improvements in human health.…”
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    Translating Developmental Origins: Improving the Health of Women and Their Children Using a Sustainable Approach to Behaviour Change
  7. 11667
    por El-Kassas, Germine, Ziade, Fouad
    Publicado 2017
    “…The coexistence of under- and overnutrition among institutionalized children calls for implementation of comprehensive intervention strategies committed to reducing undernutrition while simultaneously preventing overnutrition through improving diet quality and physical activity of these children.…”
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    The Dual Burden of Malnutrition and Associated Dietary and Lifestyle Habits among Lebanese School Age Children Living in Orphanages in North Lebanon
  8. 11668
    “…The inability of the transformed pOB cell line to undergo adipogenic differentiation, may suggest that osteosarcoma is derived from a cell intermediate in differentiation between an MSC and a pOB, with partial commitment to the osteoblastic lineage.…”
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    Genetically transforming human osteoblasts to sarcoma: development of an osteosarcoma model
  9. 11669
    “…This proteostatic collapse is regulated cell-nonautonomously by signals from the reproductive system that transmit the commitment to reproduction to somatic cells. Here, we asked whether the link between the reproductive system and somatic proteostasis could be uncoupled by activating downstream effectors in the gonadal longevity cascade. …”
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    Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases
  10. 11670
    “…Acetyl-CoA carboxylase is an important enzyme, which catalyzes acetyl-CoA’s carboxylation to produce malonyl-CoA and to serve as a committed step for de novo fatty acid biosynthesis in plastids. …”
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    Genome-Wide Identification and Expression Analysis of the Biotin Carboxyl Carrier Subunits of Heteromeric Acetyl-CoA Carboxylase in Gossypium
  11. 11671
    “…The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to activate brown fat-specific genes in adipocytes were unknown. …”
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    EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex
  12. 11672
    “…This suggests that successful initiation of construction of these functional centers is a checkpoint for committing to spacer removal.…”
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    The assembly factor Erb1 functions in multiple remodeling events during 60S ribosomal subunit assembly in S. cerevisiae
  13. 11673
    “…Participants completed an online questionnaire including Referee Self-Efficacy Scale (α = 0.85), Self-Determination Scale (α = 0.78), and an adaptation for Referees of the Sport Commitment Model (α = 0.80). Two hierarchical regression analyses have identified: (1) Enjoyment (β = 0.226), Couple Efficacy (β = 0.233), and Personal Awareness (β = 0.243), as predictors of Self-Efficacy; (2) Span of Co-Refereeing (β = 0.253), Perceived Quality of the Relationship (β = 0.239), and Mutual Agreement (β = 0.274), as predictors of Couple Self-Efficacy. …”
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    A structural Model of Self-efficacy in Handball Referees
  14. 11674
    “…In addition to the photo gallery, participants supported the development of a Call to Action asking the community, policy, and decision makers to commit to changing the current social, economic, and political conditions affecting individuals experiencing homelessness. …”
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    Adults Experiencing Homelessness in the US–Mexico Border Region: A Photovoice Project
  15. 11675
    “…The high expression of MCP-1 and VEGF, even after the osteogenic commitment, may support the usage of ASCs in bone regenerative protocols by recruiting both osteoblasts and osteoclasts of the host.…”
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    Cytokine, Chemokine, and Growth Factor Profile Characterization of Undifferentiated and Osteoinduced Human Adipose-Derived Stem Cells
  16. 11676
    “…Implementation of iodine deficiency control policies should include a monitoring program aligned with the commitment of reducing the population salt intake.…”
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    Iodine Status and Iodised Salt Consumption in Portuguese School-Aged Children: The Iogeneration Study
  17. 11677
    “…In conclusion, these findings support the notion that phone conversation makes individuals not constantly slower but more vulnerable to commit attention failure, and in this way, hampers stability of (primary-task) information processing.…”
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    Phone Conversation while Processing Information: Chronometric Analysis of Load Effects in Everyday-media Multitasking
  18. 11678
    “…Successful implementation of HBS and HMS training programs require country-led commitment, readiness, and follow-up to create local accountability and ownership. …”
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    Successful implementation of Helping Babies Survive and Helping Mothers Survive programs—An Utstein formula for newborn and maternal survival
  19. 11679
    “…Daily self-harm attendance records were retrieved from all 18 local Accident and Emergency Departments (AED) from 2001 to 2012. 4931 children and adolescents who committed self-harm were included. The results indicated positive correlation between daily change in stock market index, Hang Seng Index (∇HSI, per 300 points), and daily self-harm incident risk of children and adolescents, without time lag between the two. …”
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    Stock Market Fluctuations and Self-Harm among Children and Adolescents in Hong Kong
  20. 11680
    “…These most-primitive stem cells—those endowed with pluripotent or multipotent differentiation ability and that give rise to other cells more restricted in differentiation, known as tissue-committed stem cells (TCSCs) - are of particular interest. …”
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    Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging
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