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11941por Bommier, C.“…Finally, far from pathologizing suicide, the question of legally recognizing the right to (unassisted) suicide for those who commit it must be asked.…”
Publicado 2020
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11942por Lan, Jie, Rajan, Nicholas, Bizet, Martin, Penning, Audrey, Singh, Nitesh K., Guallar, Diana, Calonne, Emilie, Li Greci, Andrea, Bonvin, Elise, Deplus, Rachel, Hsu, Phillip J., Nachtergaele, Sigrid, Ma, Chengjie, Song, Renhua, Fuentes-Iglesias, Alejandro, Hassabi, Bouchra, Putmans, Pascale, Mies, Frédérique, Menschaert, Gerben, Wong, Justin J. L., Wang, Jianlong, Fidalgo, Miguel, Yuan, Bifeng, Fuks, François“…We propose that RNA cytosine 5-hydroxymethylation by Tets is a mark of transcriptome flexibility, inextricably linked to the balance between pluripotency and lineage commitment.…”
Publicado 2020
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11943por Tao, Zhennan, Li, Xuetao, Wang, Hao, Chen, Guangliang, Feng, Zibin, Wu, Yue, Yin, Haoran, Zhao, Guozheng, Deng, Zhitong, Zhao, Chaohui, Li, Yanyan, Sun, Ting, Zhou, Youxin“…Glioma‐initiating cells (GICs), which commit self‐renewal, perpetual proliferation, multidirectional differentiation, and vigorous tumorigenicity, sustain the peculiar genetic and epigenetic diversification in the GBM patients, thus, GICs result in tumor recurrence. …”
Publicado 2020
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11944“…The most common suicide method was hanging (n=21), which was usually committed in the private room using objects like door handles. …”
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11945por Cope, Heidi, Spillmann, Rebecca, Rosenfeld, Jill A., Brokamp, Elly, Signer, Rebecca, Schoch, Kelly, Kelley, Emily G., Sullivan, Jennifer A., Macnamara, Ellen, Lincoln, Sharyn, Golden‐Grant, Katie, Orengo, James P., Clark, Gary, Burrage, Lindsay C., Posey, Jennifer E., Punetha, Jaya, Robertson, Amy, Cogan, Joy, Phillips, John A., Martinez‐Agosto, Julian, Shashi, Vandana“…However, this does require increased provider time commitment, a particular challenge in the current practice of genomics.…”
Publicado 2020
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11946“…Alternatively, mesenchymal stem cells (MSCs) could be a more available cell source due to their abundance in tissues and easier to access. However, MSCs are committed to producing mesenchymal tissue and are not capable of spontaneously differentiating into neural cells. …”
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11947por Menegaux, Aurore, Hedderich, Dennis M., Bäuml, Josef G., Manoliu, Andrei, Daamen, Marcel, Berg, Ronja C., Preibisch, Christine, Zimmer, Claus, Boecker, Henning, Bartmann, Peter, Wolke, Dieter, Sorg, Christian, Stämpfli, Philipp“…Using recent advances in DWI, we tested the hypothesis of reduced FD in premature-born adults and investigated its link with the degree of prematurity and cognition. 73 premature- and 89 mature-born adults aged 25–27 years underwent single-shell DWI, from which a FD measure was derived using convex optimization modeling for microstructure informed tractography (COMMIT). Premature-born adults exhibited lower FD in numerous tracts including the corpus callosum and corona radiata compared to mature-born adults. …”
Publicado 2020
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11948“…This survey highlights the ability of professionals to adapt and commit themselves, demonstrating the relevance of day-hospitals in the field of chronic diseases (diagnosis, follow-up, rehabilitation) and also in prevention, identification and follow-up of frailty factors in elderly patients.…”
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11949por Sienkiewicz, Dorota, Maassen, Alison, Imaz-Iglesia, Iñaki, Poses-Ferrer, Elisa, McAvoy, Helen, Horgan, Rita, de Arriaga, Miguel Telo, Barnfield, Andrew“…However, it is essential to ensure adequate human and financial resources—as well as political commitment—to accomplish objectives set out during the policy dialogs. …”
Publicado 2020
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11950“…Especially feeding strategies and limitations in the committed mevalonate and olivetolic acid pathways are in focus of in silico and experimental studies to validate the scientific and commercial potential as a realistic alternative to the plant Cannabis sativa. …”
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11951“…The authors worked with RRAP partners to define a decision framework that included structured decision-making processes (SDM), a cost-benefit analysis (CBA), and a value of information (VoI) analysis, to establish the investment case for intervening on the GBR which led to success in securing Australian Government commitment for the next phase of the Program. With climate change expected to drive increased demand for significant levels of restoration and adaptation investment in large integrated social, ecological and economic assets (such as the GBR), the lessons from RRAP offer insights for the application of decision frameworks to inform public and private investment priorities.…”
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11952por Friston, Karl“…This review considers computational psychiatry from a particular viewpoint: namely, a commitment to explaining psychopathology in terms of pathophysiology. …”
Publicado 2022
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11953por Kvedaraite, Egle, Milne, Paul, Khalilnezhad, Ahad, Chevrier, Marion, Sethi, Raman, Lee, Hong Kai, Hagey, Daniel W., von Bahr Greenwood, Tatiana, Mouratidou, Natalia, Jädersten, Martin, Lee, Nicole Yee Shin, Minnerup, Lara, Yingrou, Tan, Dutertre, Charles-Antoine, Benac, Nathan, Hwang, You Yi, Lum, Josephine, Loh, Amos Hong Pheng, Jansson, Jessica, Teng, Karen Wei Weng, Khalilnezhad, Shabnam, Weili, Xu, Resteu, Anastasia, Liang, Tey Hong, Guan, Ng Lai, Larbi, Anis, Howland, Shanshan Wu, Arnell, Henrik, Andaloussi, Samir EL, Braier, Jorge, Rassidakis, Georgios, Galluzzo, Laura, Dzionek, Andrzej, Henter, Jan-Inge, Chen, Jinmiao, Collin, Matthew, Ginhoux, Florent“…Our results present a convergent dual origin model of LCH with MAPK pathway activation occurring prior to fate commitment to DC2 and DC3/Monocyte lineages and Notch-dependent cooperativity between lineages driving the development of LCH cells.…”
Publicado 2022
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11954“…Relative gene ontology (GO) category representations in unfused and fused cells revealed a functional skew of the fused transcriptome toward DNA metabolism, nucleus and ligases that are suggestive of a commitment to sexual development. However, the GO categories of unfused cells were dominated by metabolic pathways and other processes indicative of a vegetative phase. …”
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11955por Abdulrauf, Badr M. I.“…This was quite a unique and challenging case in terms of extreme external ear ptosis and malposition; however, success was achieved through adherence to basic principles and techniques, staging, collaborative support, and full commitment.…”
Publicado 2020
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11956“…We show how these challenges are avoided by exploiting the ability of the Cdk4/6 inhibitors, palbociclib, ribociclib and abemaciclib to arrest cell cycle progression at the natural control point for cell cycle commitment: the restriction point. After previous work found no change in the coupling of growth and division during recovery from CDK4/6 inhibition, we find high degrees of synchrony in cell cycle progression. …”
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11957por Malkowski, Sarah N., Atilho, Ruben M., Greenlee, Etienne B., Weinberg, Christina E., Breaker, Ronald R.“…This enzyme synthesizes the compound 5-phospho-D-ribosylamine (PRA), which is the first committed step in purine biosynthesis. The consensus model for Fibro-purF motif RNAs includes a predicted three-stem junction that carries numerous conserved nucleotide positions within the regions joining the stems. …”
Publicado 2020
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11958“…OBJECTIVE: Here, we propose a protocol for assessing the feasibility of a novel acceptance and commitment therapy (ACT)-based video game for young adults. …”
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11959“…However, there were several weaknesses in areas of clarity and consistency; the model included three new concepts (i.e., activity-related affect, commitment to a plan of action, and immediate competing demands and preference) that actually decreased these elements. …”
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11960“…The results also revealed their commitment to various fallacies and conspiracy theories while arguing the claims. …”
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