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  1. 12081
    “…Here, we demonstrate that ablation of the Brd4 gene in primary mouse bone marrow–derived mesenchymal stem cells via a conditional Brd4(fl/fl) allele suppresses osteogenic lineage commitment. Remarkably, loss of Brd4 function also enhances expression of genes in engineered adenoviral vectors, including Cre recombinase and green fluorescent protein (GFP). …”
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    Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing
  2. 12082
    “…All sites utilized diverse teams with support and commitment from institutional leadership, initial implementation in a single clinic, a process for monitoring and optimization, and use of custom software to minimize staff burden and error.…”
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    Implementing an Application Programming Interface for PROMIS Measures at Three Medical Centers
  3. 12083
    “…Unresponsive cells were probably under structural constraints or were committed to differentiating into alternative phenotypes. …”
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    A Small Fraction of Progenitors Differentiate Into Mature Adipocytes by Escaping the Constraints on the Cell Structure
  4. 12084
    “…It conveys two kinds of (potentially convoluted) information: (i) commitment of glyceraldehyde 3-phosphate to 3-phosphoglycerate versus fructose 1,6-bisphosphate metabolism; and (ii) the contribution of non-phosphorylating versus phosphorylating glyceraldehyde-3-phosphate dehydrogenase to catalysing the glyceraldehyde 3-phosphate to 3-phosphoglycerate forward reaction of glycolysis. …”
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    Carbon flux around leaf-cytosolic glyceraldehyde-3-phosphate dehydrogenase introduces a (13)C signal in plant glucose
  5. 12085
    por Carpentier, Julie, Proulx, Jean
    Publicado 2021
    “…The sample comprised 327 adolescents 12–18 years old (M = 15.8 years, SD = 1.9) who were evaluated in an outpatient clinic after committing a contact sexual assault. Official data on recidivism (criminal charges) was collected after a follow-up period of 21–162 months (M = 7.8 years, SD = 32.2). …”
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    Recidivism Rates of Treated, Non-Treated and Dropout Adolescent Who Have Sexually Offended: a Non-Randomized Study
  6. 12086
    “…But in Nigeria, this has been problematic, and the entire process is characterised by industrial actions undertaken to compel the government to commit to wage negotiations and implementation. The paper argues that the absence of functional standing machinery with a focus on labour economics, deciding the condition and time for a minimum wage review is seen as the main bane in government–labour frequent face-off in Nigeria, which has negatively impacted on harmonious industrial relations. …”
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    Analysing the Politics of Nigeria’s 2019 National Minimum Wage: Towards a Public Policy
  7. 12087
    “…Conversely, comprehensive GHG abatement that fully integrates non-CO(2) mitigation measures in addition to a net-zero CO(2) commitment can help achieve 1.5 °C stabilization. While decarbonization-driven fuel switching mainly reduces non-CO(2) emissions from fuel extraction and end use, targeted non-CO(2) mitigation measures can significantly reduce fluorinated gas emissions from industrial processes and cooling sectors. …”
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    Deep mitigation of CO(2) and non-CO(2) greenhouse gases toward 1.5 °C and 2 °C futures
  8. 12088
    “…Phylogenetic analysis of five oxidosqualene cyclases and heterologous expression allowed us to identify the first committed enzyme in cucurbitacin biosynthesis in I. amara, cucurbitadienol synthase (IaCPQ). …”
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    An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in Iberis amara
  9. 12089
    “…The safety precaution measures and full commitment to proper legislation in compliance with the environmental protection are needed in order to obtain triclosan good ecological status. …”
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    Comprehensive insight into triclosan—from widespread occurrence to health outcomes
  10. 12090
    “…Thus, a vibrant civil society, committed governments and favourable IPV laws, can lead to better IPV services during the COVID-19 pandemic period.…”
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    Impact of the COVID-19 pandemic on intimate partner violence in Sudan, Malawi and Kenya
  11. 12091
    “…BACKGROUND: Feasibility studies are often conducted before committing to a randomised controlled trial (RCT), yet there is little published evidence to inform how useful feasibility studies are, especially in terms of adding or reducing waste in research. …”
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    Are some feasibility studies more feasible than others? A review of the outcomes of feasibility studies on the ISRCTN registry
  12. 12092
    “…BACKGROUND: People with physical disabilities need exercise routines that are enjoyable, readily available in the home, adapted to their functional level, and eliminate common barriers to exercise participation related to transportation and time commitment. The purpose of the movement-to-music (M2M) study is to address these issues by establishing a remotely delivered, rhythmic exercise program for people with physical disabilities. …”
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    The movement-to-music (M2M) study: study protocol for a randomized controlled efficacy trial examining a rhythmic teleexercise intervention for people with physical disabilities
  13. 12093
    “…It was observed that the greater the degree of commitment of the patient, the greater the degree of overload of the caregiver. …”
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    Quality of Life of the Patient with Head and Neck Cancer Submitted to Radiotherapy and the Overload of Their Caregivers
  14. 12094
    “…This article is dedicated to the WHO International Year of Health and Care Workers in 2021 in recognition of their commitment during the COVID-19 pandemic. The study aims to strengthen health workforce preparedness, protection and ultimately resilience during a pandemic. …”
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    Health workforce protection and preparedness during the COVID-19 pandemic: a tool for the rapid assessment of EU health systems
  15. 12095
    “…The loss of ABCB7 did not alter expression of transcription factors required for B cell specification or commitment. While increased intracellular iron was observed in ABCB7-deficient pro-B cells, this did not lead to increased cellular or mitochondrial reactive oxygen species, ferroptosis, or apoptosis. …”
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    The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice
  16. 12096
    “…As compared to control, low-dose As(3+) exposure (100 nM and 500 nM) inhibited the expansion of CD34(+)-HPCs over the time course investigated; decreased the number of committed erythroid progenitors (BFU-E and CFU-E) and erythroblast differentiation in the subsequent stages; and caused a reduction of hemoglobin content. …”
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    Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34(+) cells and causes decreased levels of hemoglobin
  17. 12097
    “…RESULTS: The findings indicated poor transition outcomes for young people with the most severe mental health symptoms and those who committed serious offences. Three overarching themes were identified: (1) unsettling environmental factors within adult services; (2) experiences of transition management and preparation and (3) parental experiences of transition process and engagement with adult services. …”
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    Transition outcomes for young people discharged from adolescent medium secure services in England: A qualitative study exploring adolescents’ and carers’ experiences
  18. 12098
    “…LGR6+ cells can therefore be considered an early committed NPC population during embryonic and postnatal nephrogenesis with potential regenerative capability.…”
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    LGR6 marks nephron progenitor cells
  19. 12099
    “…This body of research has been underpinned by a commitment to supplementing ‘big data’ on antimicrobial prescribing practices, where available, with knowledge of the sociocultural, technical, environmental and other factors that shape prescribing behaviours. …”
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    Antimicrobial stewardship in Australia: the role of qualitative research in programme development
  20. 12100
    por Owolabi, Joshua, Bekele, Abebe
    Publicado 2021
    “…Should anything shut down, it must not be healthcare, and as such medical education should demonstrate such a level of commitment and character. Thankfully, this was what happened in many instances, including ours. …”
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    Medical educators’ reflection on how technology sustained medical education in the most critical times and the lessons learnt: Insights from an African medical school
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