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12321por Lauria, Andrea, Meng, Guohua, Proserpio, Valentina, Rapelli, Stefania, Maldotti, Mara, Polignano, Isabelle Laurence, Anselmi, Francesca, Incarnato, Danny, Krepelova, Anna, Donna, Daniela, Levra Levron, Chiara, Donati, Giacomo, Molineris, Ivan, Neri, Francesco, Oliviero, Salvatore“…Here we show that the DNMT3B-dependent DNA methylation of key developmental regulatory regions at epiblast-like cells (EpiLCs) provides an epigenetic priming that ensures flawless commitment at later stages. Using in vitro stem cell differentiation and loss of function experiments combined with high-throughput genome-wide bisulfite-, bulk-, and single cell RNA-sequencing we dissected the specific role of DNMT3B in cell fate. …”
Publicado 2023
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12322por Paludo, Ana Carolina, Lassalvia, Cintia, Mazhak, Iryna, Cacek, Jan, da Silva, Danilo Fernandes“…RESULTS: Data from interviews were gathered and coded, and the major themes were summarized as follows after performing content analysis of the data: (a) technical and tactical training took the major part of the preparation; (b) the high level of the coaches helped the team to reach the technical quality of the kata; (c) better psychological support during the preparation could improve the athletes’ performance during the training and competition; and (d) the lack of financial support compromised the commitment of the athletes during the training routine. …”
Publicado 2023
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12323por Antunes, Queila Pereira, Fernandes, Graziela Nunes Alfenas, Lemos, Stela Maris Aguiar“…In the total classification, the sample students with higher mean and median for the learning goal (which refers to a greater academic commitment) had a normal result, whereas those more prone to the performance-avoidance goal had more abnormal results. …”
Publicado 2022
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12324“…Countries and institutions committed to strengthening research capacity need to focus on the holistic growth and motivation of individuals in a way that ensures gender equality.…”
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12325por Babaie, Mohadese, Nourian, Manijeh, Atashzadeh-Shoorideh, Foroozan, Manoochehri, Houman, Nasiri, Malihe“…RESULTS: The concept of patient safety culture in NICUs included achieving professional development, constructive interactions, organizational supportive climate, management's commitment to neonatal safety, planning and implementation of neonatal developmental care, which are extracted from 5 main categories, 10 generic categories and 21 sub-categories. …”
Publicado 2023
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12326por Khan, Abdullah O., Rodriguez-Romera, Antonio, Reyat, Jasmeet S., Olijnik, Aude-Anais, Colombo, Michela, Wang, Guanlin, Wen, Wei Xiong, Sousos, Nikolaos, Murphy, Lauren C., Grygielska, Beata, Perrella, Gina, Mahony, Christopher B., Ling, Rebecca E., Elliott, Natalina E., Karali, Christina Simoglou, Stone, Andrew P., Kemble, Samuel, Cutler, Emily A., Fielding, Adele K., Croft, Adam P., Bassett, David, Poologasundarampillai, Gowsihan, Roy, Anindita, Gooding, Sarah, Rayes, Julie, Machlus, Kellie R., Psaila, Bethan“…Here, we describe a step-wise, directed-differentiation protocol in which organoids are generated from induced pluripotent stem cells committed to mesenchymal, endothelial, and hematopoietic lineages. …”
Publicado 2023
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12327por Xu, Ya-Xi, Wang, Bo, Jing, Jia-Nan, Ma, Rui, Luo, Yan-Hui, Li, Xin, Yan, Ze, Liu, Ya-Jing, Gao, Lei, Ren, Yan-Ling, Li, Meng-Hua, Lv, Feng-Hua“…Whole-genome selective sweep tests identify genes involved in preadipocyte commitment (e.g., BMP2, PDGFD) and terminal adipogenic differentiation (e.g., VEGFA), which could contribute to enhanced adipocyte hyperplasia. …”
Publicado 2023
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12328por Liu, Qiuying, Novak, Mariah K., Pepin, Rachel M., Maschhoff, Katharine R., Hu, Wenqian“…Here, we show that the CH-associated mutations R595H and R783H in Trim71 accelerate differentiation and enhance neural lineage commitment in mouse embryonic stem cells (mESCs), and reduce binding to mRNAs targeted by wild-type Trim71, consistent with previous reports. …”
Publicado 2023
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12329por Oh, Kyung Hyun, Quelapio, Maria Imelda, Morishita, Fukushi, Rahevar, Kalpeshsinh, Yanagawa, Manami, Islam, Tauhid“…DISCUSSION: The Western Pacific Region has achieved considerable progress in the diagnosis and treatment of DR-TB, in line with the evolving WHO recommendations in the past decade. The continued commitment of Member States is needed to address remaining challenges, such as the impact of the coronavirus disease pandemic, suboptimal management and health system issues.…”
Publicado 2022
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12330“…The adverse impacts of these challenges were, to some extent, mitigated by the participants’ commitment to making a positive difference in the lives of children and young people through the teaching profession, a strong work ethic and support provided by their ITE programme in the form of university-based mentors and adjustment to study requirements. …”
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12331por Akande, Oluwatosin Wuraola, Disu, Yahya, Kaduru, Chijioke, Anueyiagu, Chimezie, Oguanuo, Emeka, Ojumu, Tijesu, Akomolafe, Oreoluwa, Eziechina, Sunday Obiajunwa, Ejibe, Ukwori, Ihekweazu, Vivianne, Ochu, Chinwe Lucia, Ihekweazu, Chikwe“…In addition, we urge increased country commitment to a multi-hazard and multisectoral effort, deliberate investment in subnational risk communication systems, and investments in capacity building for risk communication activities.…”
Publicado 2023
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12332“…Sharing the lessons learned on the role of the health sector in meeting the ambitious road safety targets will help other countries to strengthen political commitment to road safety and move toward setting regional and global road traffic casualty reduction targets.…”
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12333“…They reported facilitators of SDM, including trust, effective communication, decision support, value clarification, outcome commitment, and continuous service. This study explored the different attitudes of the three stakeholders and identified various barriers and facilitators of SDM. …”
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12334por Duan, Yangyang, Du, Wenyu, Song, Zhijun, Chen, Ridao, Xie, Kebo, Liu, Jimei, Chen, Dawei, Dai, Jungui“…Herein, guided by transcriptome and phylogenetic analyses, a cycloartenol synthase and four glycosyltransferases catalyzing the committed steps in the biosynthesis of such bioactive astragalosides were functionally characterized from Astragalus membranaceus. …”
Publicado 2023
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12335por Listiowati, Ekorini, Sjaaf, Amal Chalik, Achadi, Anhari, Bachtiar, Adang, Arini, Merita, Rosa, Elsye Maria, Pramayanti, Yuyun“…This requires a high-level commitment, organizational support with a top-down approach, and integration into healthcare systems. …”
Publicado 2023
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12336por Marquez-Ramos, Francisco, Alarcon, David, Amian, Josue G., Fernandez-Portero, Cristina, Arenilla-Villalba, Maria J., Sanchez-Medina, Jose“…However, controlling for age, perseverative errors were negatively associated with the mean net score on the risky blocks of IGT; thus, those who committed more perseverative errors in the WCST were more likely to take cards from the disadvantageous decks on the last blocks of the IGT. …”
Publicado 2023
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12337por Claudio, David, Moyce, Sally, Albano, Tyler, Ibe, Ekeoma, Miller, Nick, O’Leary, Marshall“…We mapped potential steps in the mental health care continuum with two discrete outcomes: getting better or committing suicide. Using a Markov chain model, we calculated probabilities of each outcome based on projected increases in seeking help or availability of professional resources. …”
Publicado 2023
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12338“…Three main themes emerged 1) multiple communication channels and accessibility, 2) trust, and 3) lead by example to strengthen commitment to health. As there continues to be an increased need for COVID-19 vaccination, including booster vaccines, pastors may be a source to promote COVID-19 vaccine information and community outreach for COVID-19 vaccination among African Americans.…”
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12339“…The DGPPN becomes a sponsor and aims for climate neutrality by 2030 by committing to climate-friendly and energy-saving measures in the area of finance, in relation to the DGPPN congress as well as the DGPPN office.…”
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12340por Ávila-González, Daniela, Romero-Morales, Italo, Caro, Lizette, Martínez-Juárez, Alejandro, Young, Larry J., Camacho-Barrios, Francisco, Martínez-Alarcón, Omar, Castro, Analía E., Paredes, Raúl G., Díaz, Néstor F., Portillo, Wendy“…The differentiation potential of SVZ-isolated cells is conserved under in vitro conditions, suggesting a commitment to a neuronal lineage under a sociosexual context. 4. …”
Publicado 2023
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