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  1. 13041
    “…Essential facilitators have been the financial commitment to guarantee sustainable involvement of patients at these conferences, procedures for recruitment, selection and support, and dedicated time allocated in the program for patient issues. …”
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    Successful Stepwise Development of Patient Research Partnership: 14 Years’ Experience of Actions and Consequences in Outcome Measures in Rheumatology (OMERACT)
  2. 13042
    “…These findings align with emerging evidence that thymocyte self-renewal induced by progenitor deprivation carries an oncogenic risk that is modulated by intra-thymic competition from differentiation-committed cells. Although insertional proto-oncogene activation is required for the development of malignancy in humans, failure of γc-deficient thymocytes to effectively compete with this at-risk cell population may have also contributed to oncogenesis observed in early SCID-X1 trials.…”
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    Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency
  3. 13043
    “…They derive from multipotent progenitors that reside in the otic placode. Progenitor commitment is the result of cell signaling from the surrounding tissues that result in the restricted expression of SoxB1 transcription factors, Sox2 and Sox3. …”
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    Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons
  4. 13044
    “…Our results characterize P40/50 as homogeneous population of committed (high expression of Myf5), fast-proliferating muscle progenitors. …”
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    Molecular and functional heterogeneity of early postnatal porcine satellite cell populations is associated with bioenergetic profile
  5. 13045
    “…ChlH encodes the H subunit of the magnesium chelatase (also known as GUN5), which catalyzes the first committed step in chlorophyll synthesis. Our results show that the number and distribution of ribosomes on plastid mRNAs encoding chlorophyll-binding apoproteins are not substantially altered in Zm-chlH mutants, suggesting that chlorophyll has no impact on ribosome dynamics. …”
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    Translation and Co-translational Membrane Engagement of Plastid-encoded Chlorophyll-binding Proteins Are Not Influenced by Chlorophyll Availability in Maize
  6. 13046
    “…Instead of genomic damage, the tumorigenic effect is mediated through an expansion of the cancer stem cell (CSC) population, likely through dedifferentiation of lineage-committed intestinal epithelial cells. Stemness-linked intestinal tumorigenicity is directly correlated to absence of microbial virulence factor expression and is specific for intestinal cells. …”
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    Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli
  7. 13047
    “…SPSS 17.0 was used to show the frequency of major and minor errors committed in filling the DNFs. RESULTS: Surprisingly, only 1% of the examined DNFs had their cause of death section filled completely correct. …”
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    Quality of death notification forms in North West Bank/Palestine: a descriptive study
  8. 13048
    por Kim, Yeon Sil
    Publicado 2017
    “…Reirradiation protocol enrollment is highly encouraged prior to committing patient to an aggressive therapy. Radiation doses greater than 60 Gy are usually recommended for successful salvage. …”
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    Reirradiation of head and neck cancer in the era of intensity-modulated radiotherapy: patient selection, practical aspects, and current evidence
  9. 13049
    “…Records coded with ICD-10 codes: FA (X93 – assault by handgun discharge, X94 – assault by rifle, shotgun, and larger firearm discharge, or X95 – assault by other and unspecified firearm discharge) and LEIF (Y35.0) were examined, and the prevalence of HFO was determined using the well-established proxy of the percentage of suicides committed with a firearm. Gender, ethnicity, Census Division, and urbanization significantly impacted the death rates from FA and LEIF. …”
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    A longitudinal ecological study of household firearm ownership and firearm-related deaths in the United States from 1999 through 2014: A specific focus on gender, race, and geographic variables
  10. 13050
    “…RESULTS: i) Compared to control subjects, the amount of hypocretin-immunoreactivity (ir) was significantly increased in female but not in male depression patients; ii) hypothalamic hypocretin-ir showed a clear diurnal fluctuation, which was absent in depression; iii) male depressive patients who had committed suicide showed significantly increased ACC Hcrt-receptor-2-mRNA expression compared to male controls; and iv) female but not male CUMS rats showed a highly significant positive correlation between the mRNA levels of corticotropin-releasing hormone and prepro-hypocretin in the hypothalamus, and a significantly increased Hcrt-receptor-1-mRNA expression in the frontal cortex compared to female control rats. …”
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    Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression
  11. 13051
    “…Therefore, special education is different from what takes place in the regular classroom, demanding greater commitment by the teacher. There are certain behaviors, considered good teaching practices, which teachers have always been connected with to achieve good teaching and good learning. …”
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    Behavioral Patterns in Special Education. Good Teaching Practices
  12. 13052
    “…Many low-income and middle-income countries, including small island states in the Pacific, have committed to UHC and reforming their health financing systems to better align with UHC goals. …”
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    Financing for universal health coverage in small island states: evidence from the Fiji Islands
  13. 13053
    “…Overall, these studies show that in vitro cardiomyogenic commitment and continued culturing provides resistance to NAMPT inhibition and cell survival is associated with the ability to maintain cellular ATP pools despite depletion of NAD levels. …”
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    Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores
  14. 13054
    “…These findings suggest that near-misses in Candy Crush play a role in player commitment to the game, and may contribute to players playing longer than intended.…”
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    The Candy Crush Sweet Tooth: How ‘Near-misses’ in Candy Crush Increase Frustration, and the Urge to Continue Gameplay
  15. 13055
    “…Additionally, the respondents are aware of the importance of OSH in transport activities, but the level of integration does not measure up to the standard to reduce operational accidents and injuries. Finally, strong commitment to changing unsafe practices at all levels of operations appears to be the effective way to improve safety situations. …”
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    Safety and Health Perceptions in Work-related Transport Activities in Ghanaian Industries
  16. 13056
    “…We suggest that ATOH7 specifies RGC-committed progenitors and that Dlx1 and Dlx2 function both downstream of ATOH7 and in parallel, but cooperative, pathways that involve regulation of Brn3b expression to determine RGC fate.…”
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    Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina
  17. 13057
    “…The filarial worms affect the lymphatic system which leads to abnormal enlargement of body parts, chronic pain, disability, and social discrimination. In 1999, a commitment was made to eliminate LF from the Pacific Region by 2010. …”
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    Impact of the Lymphatic Filariasis Control Program towards elimination of filariasis in Vanuatu, 1997–2006
  18. 13058
    “…Though individual clinicians, care teams and health organizations may be interested and deeply committed to engage patients and family members in the medical course, they may lack clarity about how to achieve this goal. …”
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    Fertilizing a Patient Engagement Ecosystem to Innovate Healthcare: Toward the First Italian Consensus Conference on Patient Engagement
  19. 13059
    “…PMX53 had a direct regulatory effect on Treg commitment and increased TGF-β1 expression. Thus, C5aR signaling may induce and intensify cGVHD by down-regulating Treg induction. …”
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    Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg
  20. 13060
    “…CONCLUSIONS: Arousal and satisfaction by virtual enactment of sexual phantasies may be attractive for anxiously attached persons who find it difficult to commit to a real life relationship due to fear of rejection or low self-esteem. …”
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    Prevalence and determinants of online-sex use in the German population
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