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  1. 13181
    “…Improving our understanding of immunometabolism and immune-cell commitment to specific metabolic fates will help identify alternative therapeutic approaches to battle this intractable disease.…”
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    The Sweet Surrender: How Myeloid Cell Metabolic Plasticity Shapes the Tumor Microenvironment
  2. 13182
    “…This series of RCTs is the first committed to the evaluation of a dietary TCM formula and will hopefully establish an evidence-based clinical research model for dietary TCM formulas. …”
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    Efficacy and Safety of Hou Gu Mi Xi on Spleen Qi Deficiency in Patients with Nonorganic Gastrointestinal Disorders: Protocol for a Multicenter, Randomized, Placebo-Controlled Trial
  3. 13183
    “…The mononuclear cell (MNC) fraction of blood contains circulating progenitors committed to endothelial lineage. These progenitors give rise to endothelial colony-forming cells (ECFCs) that actively participate in neovascularization of ischemic tissue. …”
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    Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential
  4. 13184
    “…In adopting the United Nations’ sustainable development goals, governments have committed to providing equitable and universal health coverage. …”
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    Indigenous language and inequitable maternal health care, Guatemala, Mexico, Peru and the Plurinational State of Bolivia
  5. 13185
    “…The RD was organised around a series of voluntary agreements that aim to bring together government, academic experts, and commercial, public sector and voluntary organisations to commit to pledges to undertake actions of public health benefit. …”
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    The Public Health Responsibility Deal: Using a Systems-Level Analysis to Understand the Lack of Impact on Alcohol, Food, Physical Activity, and Workplace Health Sub-Systems
  6. 13186
    “…In addition to recommendations for development of high-quality multicenter clinical trials, another important recommendation was that physicians and institutions offering biologic therapies commit to establishing high-quality patient registries and biorepository-linked registries that can be used for postmarket surveillance and quality assessments.…”
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    Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference
  7. 13187
    “…Tackling these issues requires sensitivity to nuances of communication and a commitment to clarity and consistency. It also benefits from an awareness of different approaches to ethical theory. …”
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    Ethics in genetic counselling
  8. 13188
    “…Surprisingly, these first generation blood parasites already show strong signature of transmission, which indicates the commitment from asexual-to-sexual stages. Further, we place the results within the context of P. vivax’s complex life cycle, by developing mathematical models for P. vivax and P. falciparum and using sensitivity analysis assess the relative epidemiological impact of possible early stage transmission. …”
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    Plasmodium vivax readiness to transmit: implication for malaria eradication
  9. 13189
    por Colins, Olivier F., Grisso, Thomas
    Publicado 2019
    “…CONCLUSIONS: The small number of relations and their small effect sizes suggest little likelihood that screening for mental health problems in boys who are detained in the Netherlands offers any potential for identifying youth at risk for committing future violent crimes. The current findings also suggest that ethnic differences in the relation between mental health problems and future criminality must be considered in future studies. …”
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    The relation between mental health problems and future violence among detained male juveniles
  10. 13190
    “…These metrics also provide a superb set of criteria for designing superior marker systems for a target QTL, enabling the selection of an optimal marker set before committing to design.…”
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    Criteria for evaluating molecular markers: Comprehensive quality metrics to improve marker-assisted selection
  11. 13191
    “…False-positive results commit patients to undergo further, potentially invasive and ultimately unnecessary diagnostic testing – which has both financial and emotional costs. …”
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    Weighing the benefits of hepatocellular carcinoma surveillance against potential harms
  12. 13192
    “…Our data support that increased BMP signaling in Acvr1(R206H/+) cells alters the tissue microenvironment and results in misinterpretation of the tissue microenvironment through altered sensitivity to mechanical stimuli that lowers the threshold for commitment to chondro/osteogenic lineages.…”
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    ACVR1(R206H) FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification
  13. 13193
    “…Notably, markers of prenatal androgenization and the methylation status of the androgen receptor gene were correlated with the total number of sexual offenses committed. This study demonstrates alterations of the androgen system on a prenatal, epigenetic, and endocrine level. …”
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    Child sexual offenders show prenatal and epigenetic alterations of the androgen system
  14. 13194
    “…The intervention is delivered in a group format over 7 weeks; content is based on Acceptance and Commitment Therapy (ACT), an acceptance, mindfulness, and values-based intervention. …”
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    A randomized controlled trial of a group acceptance-based intervention for cancer survivors experiencing anxiety at re-entry (‘Valued Living’): study protocol
  15. 13195
    “…There is also evidence to suggest a lack of commitment to and understanding of policy guidance in relation to Clinical Commissioning Group responsibility for commissioning veteran-specific services. …”
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    Utilisation of the principles of the Armed Forces Covenant in NHS Trusts and Clinical Commissioning Groups across England: a freedom of information investigation
  16. 13196
    por DiMario, Robert J, Cousins, Asaph B
    Publicado 2019
    “…Phosphoenolpyruvate (PEP) carboxylase (PEPc) catalyzes the first committed step of C(4) photosynthesis generating oxaloacetate from bicarbonate (HCO(3)(−)) and PEP. …”
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    A single serine to alanine substitution decreases bicarbonate affinity of phosphoenolpyruvate carboxylase in C(4)Flaveria trinervia
  17. 13197
    “…Here, we demonstrate that PEP2 activity prevents the up-regulation of the A. alpina floral meristem identity genes FRUITFUL (AaFUL), LEAFY (AaLFY), and APETALA1 (AaAP1), ensuring floral commitment during vernalization. Young pep2 seedlings respond to vernalization, suggesting that PEP2 regulates the age-dependent response to vernalization independently of PEP1. …”
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    PERPETUAL FLOWERING2 coordinates the vernalization response and perennial flowering in Arabis alpina
  18. 13198
    “…DISCUSSION: Incorporating cultural humility is key to fostering a commitment to lifelong learning and maintaining learners' confidence when working with marginalized populations. …”
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    Lesbian, Gay, Bisexual, and Transgender Adolescent Health: An Interprofessional Case Discussion
  19. 13199
    “…However, the implementation of interventions could be further improved since it turned out to be very challenging to keep up participants’ commitment to the program. Future research should study the effectiveness of this program further with an improved study design (control group, multiple follow-ups, several data sources).…”
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    Effect of a participative action intervention program on reducing mental retirement
  20. 13200
    “…To this end, PCR Array was applied covering molecules involved in osteoblastic cell proliferation, commitment or differentiation, extracellular matrix (ECM) deposition, mineralisation, osteocyte maturation, angiogenesis, osteoclastic differentiation, and initial bone remodeling. …”
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    Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells
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