“…We recently found that the Mycobacterium tuberculosis MenD, the first committed enzyme of the MK biosynthesis pathway, is allosterically inhibited by the downstream metabolite 1,4-dihydroxy-2-naphthoic acid (DHNA). …”
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“…Interferon regulatory factor 8 (IRF8) is a crucial transcription factor for hematological lineage commitment, but its role in T‐ALL is unclear. Here, IRF8 is shown to suppress T‐ALL. …”
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“…“Hooking up” refers to the act of experiencing sexual intimacy with strangers without committing to a romantic relationship. Social media provide more convenient conditions for hooking up; however, it also poses a greater risk for HIV infection. …”
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“…This article takes a narrative synthesis approach to identify key themes across the studies, paying particular attention to multisectoral determinants, changes in the food environment, the role of structural factors (including longstanding social inequities), and changes in political commitment, cross-sectoral coherence and capacity. Given the inherent multisectoral nature of nutrition, many countries are experimenting with different models of ensuring coherence across sectors that are captured in this body of work. …”
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“…BACKGROUND: Continuing professional development (CPD) is a key aspect to fulfil a commitment to lifelong learning for professionals registered with the Medical and Dental Council, the intention being to promote the health of patients and develop clinical expertise. …”
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“…These approaches require solid commitment and practical-oriented leadership. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10668-023-02956-0.…”
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“…Also, the full achievement of the sustainability goals of Benefit Corporations passes also through their strongly commitment towards the CE principles. Further, the incorporation of a culture characterized by high entrepreneurial principles towards CE will likely push individuals to build an entrepreneurial mindset for the effective and sustainable development of Benefit Corporations. …”
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“…One theme, having person-focused approach, comprised four categories: ‘considering the patient’s life situation’, ‘establishing a trusting relationship with patients’, ‘strengthening patients’ commitment to oral health’ and ‘health education’. The other theme, perceiving social responsibility for oral health, comprised three categories: ‘dissemination of oral health knowledge’, ‘interprofessional collaboration’ and ‘equality in oral health care’. …”
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“…We show that 2N extraction allows the identification of short and long vocal renditions from continuous data streams without initially committing to a particular segmentation of the data. …”
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“…WA was depicted as a mechanism to support applicants of high academic ability and exhibiting commitment to studying dentistry but who were unable to show their true potential due to their underprivileged backgrounds. …”
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“…In which, the levels of cytokines IFN-γ and TNF-α in serum increased, and consequently the expression levels of transcription factors Batf2 and IRF8 involved in myeloid differentiation were up-regulated, while the expression levels of transcription factors GATA2 and NOTCH1 involved in lymphoid commitment were down-regulated, and the proliferating activity of bone marrow (BM) lineage(-) c-Kit(+) (LK) cells decreased. …”
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“…Other facilitators included strong collaboration between stakeholders, commitment to shared investment costs and involvement of regulators. …”
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“…Hence, our findings suggest the existence of a novel feedback mechanism in which lactate produced by activated, differentiating T cells skews their lineage commitment towards the regulatory fate.…”
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“…DISCUSSION: These results suggest that the greater commitment to Corporate Social Responsibility of companies with women on their boards of directors is due, in part, to the greater individual or personal social responsibility of women. …”
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“…Many topics can be addressed through international cooperations but political willingness and commitment in the respective countries plays the crucial role. …”
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“…In neuroblastoma (NB), one of the most frequent solid pediatric cancer entities, two major SE-directed molecular subtypes have been described: A more lineage-committed adrenergic (ADRN) and a mesenchymal (MES) subtype. …”
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“…In most cases, the individual resilience strategies put in place and the different forms of social support enabled them to cope with stress and maintain their commitment. However, some interviewees would have benefited from improved managerial support. …”
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“…Added to this is a scant commitment to the variety of resources and options offered by the Internet. …”
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“…Human values provide essential insights into how personal characteristics can help build a more positive work environment within an educational context, impacting variables such as organizational commitment and satisfaction with university life. However, it is still unknown to what extent values can help to influence the teachers’ level of work engagement. …”
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“…This paper makes a conceptual contribution by exploring the potential of this paradigm shift in higher education. Through a commitment to advancing transformative climate justice, colleges and universities around the world could realign and redefine their priorities in teaching, research, and community engagement to shape a more just, stable, and healthy future. …”
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