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  1. 15481
    “…CONCLUSIONS: With adequate support, a cadre of committed patient leaders can provide substantial value to design and implementation of a major multicenter clinical trial.…”
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    Exploring Meaningful Patient Engagement in ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness)
  2. 15482
    “…AIMS: Long noncoding RNAs (lncRNAs) are critical regulators of cardiovascular lineage commitment and heart wall development, but their roles in regulating endogenous cardiac regeneration are unclear. …”
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    Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration
  3. 15483
    “…All participating centres made a commitment to prospectively collect data on consecutive patients with stroke treated with IVT using standardised definitions of variables and outcomes, to assure accuracy and completeness of the data and to adapt their local databases to answer novel research questions. …”
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    Cohort profile: Thrombolysis in Ischemic Stroke Patients (TRISP): a multicentre research collaboration
  4. 15484
    “…Interestingly, antioxidants were able to completely counteract UBCS039-induced autophagy, suggesting that ROS burst had a key role in upstream events leading to autophagy commitment. Finally, sustained activation of SIRT6 resulted in autophagy-related cell death, a process that was markedly attenuated using either a pan caspases inhibitor (zVAD-fmk) or an autophagy inhibitor (CQ). …”
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    Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
  5. 15485
    “…Co-teaching requires the commitment of both faculty members to this pedagogy.…”
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    Modeling integration: co-teaching basic and clinical sciences medicine in the classroom
  6. 15486
    “…Key factors include the importance of high level political commitment; the incentives for competition versus collaboration between bureaucratic agencies and the extent to which there is common understanding across actors about the problem. …”
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    Governing multisectoral action for health in low-income and middle-income countries: unpacking the problem and rising to the challenge
  7. 15487
    “…Primary outcome variables including mental health stigma, help-seeking behaviour and perception of the workplace commitment to mental health were measured prior to program implementation, and then again 10 months following using a paper based survey. …”
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    Feasibility and acceptability of strategies to address mental health and mental ill-health in the Australian coal mining industry
  8. 15488
    por Vicedo-Cabrera, Ana Maria, Guo, Yuming, Sera, Francesco, Huber, Veronika, Schleussner, Carl-Friedrich, Mitchell, Dann, Tong, Shilu, Coelho, Micheline de Sousa Zanotti Stagliorio, Saldiva, Paulo Hilario Nascimento, Lavigne, Eric, Correa, Patricia Matus, Ortega, Nicolas Valdes, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Pascal, Mathilde, Goodman, Patrick G., Zeka, Ariana, Michelozzi, Paola, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Hurtado-Diaz, Magali, Cruz, Julio, Seposo, Xerxes, Kim, Ho, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Daniel Oudin, Ragettli, Martina S., Röösli, Martin, Guo, Yue Leon, Wu, Chang-fu, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Dang, Tran Ngoc, Do Van, Dung, Heaviside, Clare, Vardoulakis, Sotiris, Hajat, Shakoor, Haines, Andy, Armstrong, Ben, Ebi, Kristie L., Gasparrini, Antonio
    Publicado 2018
    “…The Paris Agreement binds all nations to undertake ambitious efforts to combat climate change, with the commitment to “hold warming well below 2 °C in global mean temperature (GMT), relative to pre-industrial levels, and to pursue efforts to limit warming to 1.5 °C”. …”
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    Temperature-related mortality impacts under and beyond Paris Agreement climate change scenarios
  9. 15489
    “…METHODS: Immortalized human myoblasts were co-cultured with hESCs derived committed NPCs. Over the course of the 7 days myoblasts differentiated into myotubes and NPCs differentiated into motor neurons. …”
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    A functional human motor unit platform engineered from human embryonic stem cells and immortalized skeletal myoblasts
  10. 15490
    “…When exposed to high illuminance lighting subjects experienced reduced sleepiness scores on the Stanford Sleepiness Scale than when exposed to standard hospital lighting: mean (sem) 2.6 (0.2) vs. 3.0 (0.2), p = 0.03. However, they committed more psychomotor errors: 2.3 (0.2) vs. 1.7 (0.2), p = 0.03. …”
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    Bright environmental light improves the sleepiness of nightshift ICU nurses
  11. 15491
    “…We outline 5 key challenges (scope of projects, unrealistic expectations set by existing guidance, the discrepancy between IT realities in healthcare and our broader lives, information governance and ‘death register’ associations) and 6 key drivers (robust concept, striking outcomes, national support and strong clinical leadership, clinician commitment, education and funding). CONCLUSIONS: The priorities for advancing EPaCCS we propose include linking to other work streams and reframing the concept, potentially making it less ‘end of life’, overview of current EPaCCS and lessons learnt, continuing work on information standards, rethinking of national funding and new levels of individual and community involvement.…”
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    Crash course in EPaCCS (Electronic Palliative Care Coordination Systems): 8 years of successes and failures in patient data sharing to learn from
  12. 15492
    “…The formalised dialogue required in this structured buddying programme took time and commitment from both sides. The programme illustrated the importance of researchers listening, and policymakers understanding what research can offer. …”
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    Researcher and policymaker dialogue: the Policy BUDDIES Project in Western Cape Province, South Africa
  13. 15493
    “…PMAs were also found to increase commitment and contributed to improving teamwork and prudent use of resources. …”
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    An assessment of a performance-based management agreement initiative in Ghana’s health service
  14. 15494
    “…OBJECTIVES: Public service motivation refers to the idea of commitment to the public service, pursuit of the public interest, and the desire to perform work that is worthwhile to society. …”
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    How job stress influences job performance among Chinese healthcare workers: a cross-sectional study
  15. 15495
    “…The results of this study indicate the need to examine new intervention approaches to increase uptake that recognize and address feelings of pressure and parental commitment to choice.…”
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    Maternal perceptions of childhood vaccination: explanations of reasons for and against vaccination
  16. 15496
    “…Completing and improving this list is a long-term, high-value commitment that will require a collaborative approach involving ecologists, taxonomists, and practitioners.…”
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    Towards a dynamic list of Amazonian tree species
  17. 15497
    “…Phytoene synthase (PSY) mediates the first committed step in carotenoid biosynthesis in plants. …”
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    The Specialized Roles in Carotenogenesis and Apocarotenogenesis of the Phytoene Synthase Gene Family in Saffron
  18. 15498
    “…Moreover, blocking the function of miR-184 reduced the number of committed cells to an OL lineage. CONCLUSIONS: Our data highlighted that miR-184 could promote OL differentiation even in the absence of exogenous growth factors and propose a novel strategy to improve the efficacy of OL differentiation, with potential applications in cell therapy for neurodegenerative diseases. …”
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    A critical role for miR-184 in the fate determination of oligodendrocytes
  19. 15499
    “…We believe that the work of Push the Pace has initiated a strong commitment to a culture of continuous improvement in the NIHR. …”
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    Health research systems in change: the case of ‘Push the Pace’ in the National Institute for Health Research
  20. 15500
    “…Which level of care a patient receives appears to depend markedly on the respective non-governmental organisation and the individual commitment, subjective decisions and personal connections of the treating physician. …”
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    ‘Managing scarcity’– a qualitative study on volunteer-based healthcare for chronically ill, uninsured migrants in Berlin, Germany
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