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15921por Treweek, Shaun, Wilkie, Erna, Craigie, Angela M, Caswell, Stephen, Thompson, Joyce, Steele, Robert JC, Stead, Martine, Anderson, Annie S“…CONCLUSIONS: Recruitment to multicentre trials is a challenge but can be successfully achieved with a committed team. In a UK context, NHS research and development approval can be a substantial source of delay. …”
Publicado 2013
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15922por Lipsky, Ari M, Karsteadt, Larry L, Gausche-Hill, Marianne, Hartmans, Sharon, Bongard, Frederick S., Cryer, Henry Gill, Ekhardt, Patricia B, Loffredo, Anthony J, Farmer, Patricia D, Whitney, Susan C, Lewis, Roger J“…The rural system utilized in this study, with low volume and high blunt trauma rates, can effectively care for its population of trauma patients with an enhanced, committed trauma system, which allows for expeditious movement of patients toward definitive care.…”
Publicado 2014
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15923por Cao, Suying, Han, Jianyong, Wu, Jun, Li, Qiuyan, Liu, Shichao, Zhang, Wei, Pei, Yangli, Ruan, Xiaoan, Liu, Zhonghua, Wang, Xumin, Lim, Bing, Li, Ning“…Specific gene expression analysis of the putative inner cell mass (ICM) and the trophectoderm (TE) revealed that pig and mouse pre-implantation embryos share regulatory networks during the first lineage segregation and primitive endoderm differentiation, but not during ectoderm commitment. Also, fatty acid metabolism appears to be a unique characteristic of pig pre-implantation embryonic development. …”
Publicado 2014
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15924por Guglielmi, L, Cinnella, C, Nardella, M, Maresca, G, Valentini, A, Mercanti, D, Felsani, A, D'Agnano, I“…Therefore, our idea is that MYCN is necessary during the activation of neuroblastoma differentiation to induce apoptosis in cells that are not committed to differentiate.…”
Publicado 2014
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15925“…She raised our interest because of possible psychiatric issues, as she had attempted to commit suicide. The prescription of antidepressants led to a significant clinical improvement. …”
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15926por da SILVA, Andressa Sharllene Carneiro, RIZZANTE, Fabio Antonio Piola, PICOLINI, Mirela Machado, de CAMPOS, Karis, CORRÊA, Camila de Castro, FRANCO, Elen Caroline, PARDO-FANTON, Cássia de Souza, BLASCA, Wanderléia Quinhoneiro, BERRETIN-FELIX, Giédre“…RESULTS: In four years of activities, the TLFOB-USP obtained a high satisfaction index (90%), an increased number of vacancies due to the interest to become a member, more commitment of the professors of the University and the accomplishment of association with other Brazilian leagues. …”
Publicado 2011
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15927por Irimu, Grace W, Greene, Alexandra, Gathara, David, Kihara, Harrison, Maina, Christopher, Mbori-Ngacha, Dorothy, Zurovac, Dejan, Santau, Migiro, Todd, Jim, English, Mike“…Possible root causes of this performance variability included challenges in keeping knowledge and clinical skills updated, inadequate commitment of the staff to continued improvement, limited exposure to positive professional role models, poor teamwork, failure to maintain professional integrity and mal-adaptation to institutional pressures. …”
Publicado 2014
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15928por Boggs, Jennifer M, Beck, Arne, Felder, Jennifer N, Dimidjian, Sona, Metcalf, Christina A, Segal, Zindel V“…Participants endorsed developing affect regulation skills and identified several advantages to Web-based delivery including flexibility, reduced cost, and time commitment. CONCLUSIONS: These findings support the viability of providing MBCT online and are consistent with prior qualitative accounts derived from in-person MBCT groups. …”
Publicado 2014
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15929por Davila, Jonathan L., Goff, Loyal A., Ricupero, Christopher L., Camarillo, Cynthia, Oni, Eileen N., Swerdel, Mavis R., Toro-Ramos, Alana J., Li, Jiali, Hart, Ronald P.“…We utilized two immortalized rat precursor clones, one committed to neurogenesis (L2.2) and another capable of producing both neurons and non-neuronal cells (L2.3), to reproducibly study early neurogenesis. …”
Publicado 2014
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15930por Chimenti, Isotta, Gaetani, Roberto, Forte, Elvira, Angelini, Francesco, De Falco, Elena, Zoccai, Giuseppe Biondi, Messina, Elisa, Frati, Giacomo, Giacomello, Alessandro“…In conclusion, the use of HSs for the isolation and expansion of CSs/CDCs has to be excluded because of altered proliferation and/or commitment, while media supplemented with B27 and the selected giFBS allows successful EU GMP-complying CPCs culture.…”
Publicado 2014
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15931por Saccone, Valentina, Consalvi, Silvia, Giordani, Lorenzo, Mozzetta, Chiara, Barozzi, Iros, Sandoná, Martina, Ryan, Tammy, Rojas-Muñoz, Agustin, Madaro, Luca, Fasanaro, Pasquale, Borsellino, Giovanna, De Bardi, Marco, Frigè, Gianmaria, Termanini, Alberto, Sun, Xin, Rossant, Janet, Bruneau, Benoit G., Mercola, Mark, Minucci, Saverio, Puri, Pier Lorenzo“…However, the molecular mechanism that controls FAP lineage commitment and activity is currently unknown. We show here that an HDAC–myomiR–BAF60 variant network regulates the fate of FAPs in dystrophic muscles of mdx mice. …”
Publicado 2014
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15932“…The questionnaire examined communication, collaborative research, dissemination of research, research findings, negotiation, partnership enhancement, information needs, rapport, and commitment. The interviews elicited feedback about partners’ experiences with being part of the network. …”
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15933por Balbous, A, Cortes, U, Guilloteau, K, Villalva, C, Flamant, S, Gaillard, A, Milin, S, Wager, M, Sorel, N, Guilhot, J, Bennaceur-Griscelli, A, Turhan, A, Chomel, J-C, Karayan-Tapon, L“…Our results also showed that all GSC lines have the capacity to commit to neural differentiation and express mesenchymal or endothelial differentiation markers. …”
Publicado 2014
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15934por Kadoya, Taku, Takenaka, Akio, Ishihama, Fumiko, Fujita, Taku, Ogawa, Makoto, Katsuyama, Teruo, Kadono, Yasuro, Kawakubo, Nobumitsu, Serizawa, Shunsuke, Takahashi, Hideki, Takamiya, Masayuki, Fujii, Shinji, Matsuda, Hiroyuki, Muneda, Kazuo, Yokota, Masatsugu, Yonekura, Koji, Yahara, Tetsukazu“…Thus, the Aichi Biodiversity Target to expand PAs to 17% of land (and inland water) areas, as committed to by many national governments, is not enough: only 29.2% of currently threatened species will become non-threatened under the assumption that probability of protection success by PAs is 0.5, which our assessment shows is realistic. …”
Publicado 2014
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15935por Lee, Mon-Juan, Chen, Hui-Ting, Ho, Mei-Ling, Chen, Chung-Hwan, Chuang, Shu-Chun, Huang, Sung-Cheng, Fu, Yin-Chih, Wang, Gwo-Jaw, Kang, Lin, Chang, Je-Ken“…This study investigates the role of PPARγ in the lineage commitment of human adipose-derived mesenchymal stem cells (hADSCs) by interfering with the function of PPARγ mRNA through small interfering RNAs (siRNAs) specific for PPARγ2. …”
Publicado 2013
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15936por Haymond, Amanda, Johny, Chinchu, Dowdy, Tyrone, Schweibenz, Brandon, Villarroel, Karen, Young, Richard, Mantooth, Clark J., Patel, Trishal, Bases, Jessica, Jose, Geraldine San, Jackson, Emily R., Dowd, Cynthia S., Couch, Robin D.“…Because mammals synthesize isoprenoids via an alternate pathway, the bacterial MEP pathway is an attractive target for novel antibiotic development, necessitated by emerging antibiotic resistance as well as biodefense concerns. The first committed step in the MEP pathway is the reduction and isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to methylerythritol phosphate (MEP), catalyzed by MEP synthase. …”
Publicado 2014
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15937por Bose, Anindya Sekhar, Jafari, Hamid, Sosler, Stephen, Narula, Arvinder Pal Singh, Kulkarni, V. M., Ramamurty, Nalini, Oommen, John, Jadi, Ramesh S., Banpel, R. V., Henao-Restrepo, Ana Maria“…BACKGROUND: According to WHO estimates, 35% of global measles deaths in 2011 occurred in India. In 2013, India committed to a goal of measles elimination by 2020. …”
Publicado 2014
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15938por Walzer, Sonja M, Cetin, Erdal, Grübl-Barabas, Ruth, Sulzbacher, Irene, Rueger, Beate, Girsch, Werner, Toegel, Stefan, Windhager, Reinhard, Fischer, Michael B“…These immature vessels in the growth plate showed no abluminal coverage with α-SMA(+) smooth muscle cells, but in their close proximity single CD133(+) precursor cells were found that did not express VEGFR-2, a marker for endothelial lineage commitment. In periosteum and in the perichondrial groove of Ranvier that harboured CD90(+)/CD105(+) chondro-progenitors, in contrast, mature vessels were found stabilized by α-SMA(+) smooth muscle cells. …”
Publicado 2014
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15939por Han, Xuemei, Smyth, Regan L., Young, Bruce E., Brooks, Thomas M., Sánchez de Lozada, Alexandra, Bubb, Philip, Butchart, Stuart H. M., Larsen, Frank W., Hamilton, Healy, Hansen, Matthew C., Turner, Will R.“…Recognizing the imperiled status of biodiversity and its benefit to human well-being, the world's governments committed in 2010 to take effective and urgent action to halt biodiversity loss through the Convention on Biological Diversity's “Aichi Targets”. …”
Publicado 2014
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15940por van Panhuis, Willem G, Paul, Proma, Emerson, Claudia, Grefenstette, John, Wilder, Richard, Herbst, Abraham J, Heymann, David, Burke, Donald S“…BACKGROUND: In the current information age, the use of data has become essential for decision making in public health at the local, national, and global level. Despite a global commitment to the use and sharing of public health data, this can be challenging in reality. …”
Publicado 2014
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