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15941“…Therefore, understanding the mechanisms underlying the commitment of neural progenitor cells (NPCs) is important for the application of hPSCs in neurodegenerative disease therapies. …”
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15942por Vieira, Brittany L., Lanier, Steven T., Mlodinow, Alexei S., Bethke, Kevin P., Murphy, Robert X., Hume, Keith M., Gutowski, Karol A., Fine, Neil A., Kim, John Y. S.“…This finding underscores the commitment of the plastic surgery community to providing consistent care for patients, irrespective of insurance status.…”
Publicado 2014
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15943por Haralalka, Shruti, Shelton, Claude, Cartwright, Heather N., Guo, Fengli, Trimble, Rhonda, Kumar, Ram P., Abmayr, Susan M.“…The process of myogenesis includes the recognition, adhesion, and fusion of committed myoblasts into multinucleate syncytia. In the larval body wall muscles of Drosophila, this elaborate process is initiated by Founder Cells and Fusion-Competent Myoblasts (FCMs), and cell adhesion molecules Kin-of-IrreC (Kirre) and Sticks-and-stones (Sns) on their respective surfaces. …”
Publicado 2014
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15944por Maun, Andy, Engström, Miriam, Frantz, Anna, Brämberg, Elisabeth Björk, Thorn, Jörgen“…In an overall perspective the system was conceived as being an appropriate platform for promoting transformation into an effective patient-centred primary healthcare team in which organizational development was perceived as a continuous participative process demanding the commitment of all team members. CONCLUSIONS: This study demonstrates that the introduction of a structured patient-sorting system makes it possible for several important change processes to take place concurrently: improvement of healthcare processes, empowerment of professionals and team development. …”
Publicado 2014
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15945por Neganova, I, Tilgner, K, Buskin, A, Paraskevopoulou, I, Atkinson, S P, Peberdy, D, Passos, J F, Lako, M“…To investigate the impacts of CDK1 downregulation, we performed RNA interference studies which in addition to expected mitotic deficiencies revealed a large range of additional phenotypes related to maintenance of pluripotency, ability to repair double strand breaks (DSBs) and commitment to apoptosis. Downregulation of CDK1 led to the loss of typical pluripotent stem cell morphology, downregulation of pluripotency markers and upregulation of a large number of differentiation markers. …”
Publicado 2014
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15946“…Both effort–reward ratio (ERR) and scores of over-commitment were positively associated with depressive symptoms, whereas psychological capital was negatively associated with depressive symptoms among university teachers. …”
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15947“…The latest levels and trends in child mortality as well as the coverage and quality of key maternal and newborn care from pregnancy through childbirth and the postnatal period are the subject of the new UNICEF report Committing to Child Survival: A Promise Renewed Progress Report 2014 released recently in September. …”
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15948por White, Katherine M, Jimmieson, Nerina L, Obst, Patricia L, Graves, Nicholas, Barnett, Adrian, Cockshaw, Wendell, Gee, Phillip, Haneman, Lara, Page, Katie, Campbell, Megan, Martin, Elizabeth, Paterson, David“…CONCLUSIONS: The belief base of the theory of planned behaviour provided a useful framework to explore systematically the underlying beliefs of nurses’ hand hygiene decisions according to the 5 critical moments, allowing comparisons with previous belief studies. A commitment to improve nurses’ hand hygiene practice across the 5 moments should focus on individual strategies to combat distraction from other duties, peer-based initiatives to foster a sense of shared responsibility, and management-driven solutions to tackle staffing and resource issues. …”
Publicado 2015
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15949“…The UK cancer genetics community have high expertise and strong commitment to maximising scientific advances for improved patient benefit and should be pivotally involved in the implementation of increased cancer gene testing. …”
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15950“…These barriers can be overcome by committed leadership and the development of an information-based implementation plan. …”
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15951por Wiesner, Darin L., Specht, Charles A., Lee, Chrono K., Smith, Kyle D., Mukaremera, Liliane, Lee, S. Thera, Lee, Chun G., Elias, Jack A., Nielsen, Judith N., Boulware, David R., Bohjanen, Paul R., Jenkins, Marc K., Levitz, Stuart M., Nielsen, Kirsten“…Thus, higher order detection of specific features of fungal infection by these dendritic cells must direct Th2 cell lineage commitment. Since chitin-containing parasites commonly elicit Th2 responses, we hypothesized that recognition of fungal chitin is an important determinant of Th2 cell-mediated mycosis. …”
Publicado 2015
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15952por Pisciotta, Alessandra, Carnevale, Gianluca, Meloni, Simona, Riccio, Massimo, De Biasi, Sara, Gibellini, Lara, Ferrari, Adriano, Bruzzesi, Giacomo, De Pol, Anto“…Both the subpopulations demonstrated similar abilities to differentiate towards mesoderm lineages, whereas a significant difference was observed after the neurogenic induction, with a greater commitment of STRO-1(+)/c-Kit(+)/CD34(+) hDPSCs. Moreover, undifferentiated STRO-1(+)/c-Kit(+)/CD34(−) hDPSCs did not show any expression of CD271 and nestin, typical neural markers, while STRO-1(+)/c-Kit(+)/CD34(+) hDPSCs expressed both. …”
Publicado 2015
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15953por Nogueira, Julia Meireles, Hawrot, Katarzyna, Sharpe, Colin, Noble, Anna, Wood, William M., Jorge, Erika C., Goldhamer, David J., Kardon, Gabrielle, Dietrich, Susanne“…The cells develop late, and well after the head mesoderm has committed to myogenesis. We propose that this unique mechanism of muscle stem cell development is a legacy of the evolutionary history of the chordate head mesoderm.…”
Publicado 2015
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15954por Hepburn, Charlotte Moore, Cohen, Eyal, Bhawra, Jasmin, Weiser, Natalie, Hayeems, Robin Z, Guttmann, Astrid“…OBJECTIVES: (1) To explore the international policy profile of paediatric-to-adult care transitions, and (2) to document policy objectives, initiatives and outcomes for jurisdictions publicly committed to addressing transition issues. METHODS: An international policy scoping review of all publicly available government documents detailing transition-related strategies was completed using a web-based search. …”
Publicado 2015
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15955por Preece, Ryan, Dickinson, Emily Clare, Sherif, Mohamed, Ibrahim, Yousef, Ninan, Ann Susan, Aildasani, Laxmi, Ahmed, Sartaj, Smith, Philip“…However, the provision of skills tutorials requires significant commitment from time-constrained surgical faculty. PURPOSE: We aimed to determine how a peer-assisted suturing workshop could enhance surgical skills competency among medical students and enthuse them towards a career in surgery. …”
Publicado 2015
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15956por Hofberger, Johannes A., Ramirez, Aldana M., van den Bergh, Erik, Zhu, Xinguang, Bouwmeester, Harro J., Schuurink, Robert C., Schranz, M. Eric“…However, robust functional annotation is often only available for core enzymes catalyzing committed reaction steps within few model systems. …”
Publicado 2015
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15957por Walters, Lucie, Laurence, Caroline O., Dollard, Joanne, Elliott, Taryn, Eley, Diann S.“…Firstly, rural GP registrars described four dichotomous tensions they faced: clinical caution versus clinical courage; flexibility versus persistence; reflective practice versus task-focused practice; and personal connections versus professional commitment. Further themes included: personal skills for balance which facilitated resilience including optimistic attitude, self-reflection and metacognition; and finally GP registrars recognised the role of their supervisors in supporting and stretching them to enhance their clinical resilience. …”
Publicado 2015
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15958“…MicroRNAs (miRNAs) emerge as important regulators of stem cell lineage commitment and bone development. MiRNA-26a (miR-26a) is one of the important miRNAs regulating osteogenic differentiation of both bone marrow-derived mesenchymal stem cells (BMSCs) and adipose tissue-derived mesenchymal stem cells (ADSCs). …”
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15959por Berti, Federica, Nogueira, Júlia Meireles, Wöhrle, Svenja, Sobreira, Débora Rodrigues, Hawrot, Katarzyna, Dietrich, Susanne“…We comparatively analysed onset and expression patterns of the key markers for the chicken immature paraxial mesoderm, for muscle-competent cells, for cells committed to myogenesis and for cells entering terminal differentiation. …”
Publicado 2015
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15960por Guidi, Micol, Ruault, Myriam, Marbouty, Martial, Loïodice, Isabelle, Cournac, Axel, Billaudeau, Cyrille, Hocher, Antoine, Mozziconacci, Julien, Koszul, Romain, Taddei, Angela“…We further show that reactive oxygen species produced by mitochondrial activity during respiration commit the cell to form a hypercluster upon starvation. …”
Publicado 2015
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