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17821por Tang, Leilei, Bergevoet, Saskia M, Gilissen, Christian, de Witte, Theo, Jansen, Joop H, van der Reijden, Bert A, Raymakers, Reinier AP“…Earlier we showed that many ABC transporters are highly expressed in hematopoietic stem cells (HSCs) compared to more committed progenitor cells. The ABC transporter expression signature may guarantee lifelong protection of HSCs but may also preserve stem cell integrity by extrusion of agents that trigger their differentiation. …”
Publicado 2010
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17822por Chittka, Alexandra“…The later appearance of the H4R3me2a modifications specifies the onset of neurogenesis and gliogenesis and the commitment of the NSCs to differentiate. Thus, the sequential appearance of the two different H4R3 methylation marks may define a particular cellular state of the NSCs during their development and differentiation demonstrating the role of histone arginine methylation in cortical development.…”
Publicado 2010
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17823“…In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis. These events were followed by activation of caspase 9, caspase 8 and caspase 3 leading to cleavage of its downstream target, poly-ADP-ribose phosphate (PARP). …”
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17824por Wilf-Miron, Rachel, Peled, Ronit, Yaari, Einat, Shem-Tov, Orna, Weinner, Vainer Anna, Porath, Avi, Kokia, Ehud“…BACKGROUND: The commitment to promoting equity in health is derived from the notion that all human beings have the right to the best attainable health. …”
Publicado 2010
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17825por De Vita, S, Canzonetta, C, Mulligan, C, Delom, F, Groet, J, Baldo, C, Vanes, L, Dagna-Bricarelli, F, Hoischen, A, Veltman, J, Fisher, E M C, Tybulewicz, V L J, Nizetic, D“…Using the transchromosomic system (mouse embryonic stem cells (ESCs)) bearing an extra human chromosome 21 (HSA21)) we analyzed the early stages of haematopoietic commitment (mesodermal colony formation) in vitro. We observed that trisomy 21 (T21) causes increased production of haemogenic endothelial cells, haematopoietic stem cell precursors and increased colony forming potential, with significantly increased immature progenitors. …”
Publicado 2010
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17826por Tagge, Edward P., Hebra, André, Goldberg, Aron, Jacques, Kathryn, Jackson, Sherron, Othersen, H. Biemann“…However, at our institution, the combination of an early commitment to laparoscopic techniques for children and access to a large population of pediatric patients with sickle cell disease have provided a significant experience with laparoscopic cholecystectomy in children. …”
Publicado 1998
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17827por Kao, Cheng-Yuan, Los, Ferdinand C. O., Huffman, Danielle L., Wachi, Shinichiro, Kloft, Nicole, Husmann, Matthias, Karabrahimi, Valbona, Schwartz, Jean-Louis, Bellier, Audrey, Ha, Christine, Sagong, Youn, Fan, Hui, Ghosh, Partho, Hsieh, Mindy, Hsu, Chih-Shen, Chen, Li, Aroian, Raffi V.“…This in vivo RNAi genomic study of PFT responses proves that cellular commitment to PFT defenses is enormous, demonstrates the JNK MAPK pathway as a key regulator of transcriptionally-induced PFT defenses, and identifies AP-1 as the first cellular component broadly important for defense against large- and small-pore PFTs.…”
Publicado 2011
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17828“…Comparing frequently admitted patients to non-frequently admitted patients commits the constant risk fallacy and potentially lowers HSMRs of hospitals treating many frequently admitted patients and increases HSMRs of hospitals treating many non-frequently admitted patients. …”
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17829“…In most tissues ethylene is a negative regulator of cell expansion, thus low basal levels of ethylene biosynthesis in dark-grown seedlings are critical for optimal cell expansion during early seedling development. The committed steps in ethylene biosynthesis are performed by the enzymes 1-aminocyclopropane 1-carboxylate synthase (ACS) and 1-aminocyclopropane 1-carboxylate oxidase (ACO). …”
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17830“…Of the remaining 6 SHAs that did include content related to climate change and energy vulnerability on their websites consistent themes were seen to emerge. These included commitment to a regional sustainability framework in collaboration with other agencies in the pursuit and promotion of sustainable development. …”
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17831por Fotu, Kalesita F, Moodie, Marj M, Mavoa, Helen M, Pomana, Siosifa, Schultz, Jimaima T, Swinburn, Boyd A“…A team of five staff in Tonga were committed to planning, implementation and evaluation of a strategic plan, the key planks of which were developed during a two day community workshop. …”
Publicado 2011
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17832“…Despite this, GPs used the tool to different degrees, though this signified a general commitment to participating in the study rather than a deeper attitude change towards the new system.…”
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17833por Lasigliè, Denise, Traggiai, Elisabetta, Federici, Silvia, Alessio, Maria, Buoncompagni, Antonella, Accogli, Andrea, Chiesa, Sabrina, Penco, Federica, Martini, Alberto, Gattorno, Marco“…In both mouse and human IL-1β has been indicated as a key cytokine for the commitment to T(H)-17 cells. Cryopyrin-associated periodic syndromes (CAPS) are a group of inflammatory diseases associated with mutations of the NLRP3 gene encoding the inflammasome component cryopyrin. …”
Publicado 2011
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17834por Quanbeck, Andrew R, Gustafson, David H, Ford, James H, Pulvermacher, Alice, French, Michael T, McConnell, K John, McCarty, Dennis“…DISCUSSION: The study offers seven recommendations for conducting a large-scale cluster-randomized trial: provide valuable services, have aims that are clear and important, seek powerful allies, understand the recruiting challenge, cultivate commitment, address turnover, and encourage rigor and flexibility. …”
Publicado 2011
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17835por Zuure, Freke R, Heijman, Titia, Urbanus, Anouk T, Prins, Maria, Kok, Gerjo, Davidovich, Udi“…Service-related reasons for not testing pertained to inconvenient testing facilities, a lack of commitment due to the low threshold character of the service, computer/printing problems, and incorrectly interpreting an online planning tool. …”
Publicado 2011
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17836por Cargo, Margaret, Marks, Elisabeth, Brimblecombe, Julie, Scarlett, Maria, Maypilama, Elaine, Dhurrkay, Joanne Garnggulkpuy, Daniel, Mark“…CONCLUSIONS: The quantity of activities with IND, INT and ORG targets and the proportion of participants recruited through informal cultural networking demonstrate community commitment to prevention. Integration of an ecological approach would have been facilitated by greater inter-organisational collaboration and centralised planning. …”
Publicado 2011
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17837por Andersen, Finn, Douglas, Nick M, Bustos, Dorina, Galappaththy, Gawrie, Qi, Gao, Hsiang, Michelle S, Kusriastuti, Rita, Mendis, Kamini, Taleo, George, Whittaker, Maxine, Price, Ric N, von Seidlein, Lorenz“…The purpose of the study is to characterize trends in malaria-related literature from 1990 to 2009 in 11 Asian-Pacific countries that are committed to malaria elimination as a national goal. …”
Publicado 2011
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17838“…HDAC inhibition results in G1 arrest in adult mouse NSCs and transcriptional changes associated with activation of neuronal lineage commitment programs and a reduction of stem/progenitor state. …”
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17839por Oikonomou, Eftychia, Koc, Michal, Sourkova, Vladimira, Andera, Ladislav, Pintzas, Alexander“…Another rational combination includes 17-AAG synergism with TRAIL in a BRAF(V600E) mutant dependent manner to commit cells to apoptosis, through DR5 and the amplification of the apoptotic pathway. …”
Publicado 2011
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17840por Hakim-Weber, Robab, Krogsdam, Anne-M, Jørgensen, Claus, Fischer, Maria, Prokesch, Andreas, Bogner-Strauss, Juliane G, Bornstein, Stefan R, Hansen, Jacob B, Madsen, Lise, Kristiansen, Karsten, Trajanoski, Zlatko, Hackl, Hubert“…Additionally, the analysis results indicate a different or additional role for pRb family member involvement in the lineage commitment. CONCLUSION: In this study a number of commonly modulated genes during adipogenesis in 3T3-L1 cells and MEFs, potential transcriptional regulation mechanisms, and differentially regulated targets during adipocyte differentiation of Rb-/- MEFs could be identified. …”
Publicado 2011
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