“…To enable this, clinical, academic and public calls for the undertaking of rigorous clinical trials to establish an evidence base for the therapeutic use of cannabis medicines have been made internationally. While this commitment to undertake human studies with cannabis medicines is welcomed, it has highlighted unique challenges, notably in the review stages of ethics and governance. …”
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“…The sponsor and the investigators are committed to conducting this study in accordance with ethics principles contained in the World Medical Association's Declaration of Helsinki (Ethical Principles for Medical Research Involving Human Subjects). …”
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“…This study found that aspects of acceptability and adequacy of services are equally valued. Additional commitment to further develop primary care through engagement of local decision-makers and professional associations is needed.…”
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“…The distalless gene family is necessary for the differentiation and tangential migration of committed neural progenitors to become GABAergic interneurons. …”
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“…The Arabic version of the HSCT, divided into automatic and inhibition conditions, was used; in each condition, participants’ response-time and number of errors committed were recorded. RESULTS: None of the scale items was removed. …”
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“…CONCLUSIONS: This study depicted a comprehensive landmark of DNA methylome of skeletal muscle-derived myogenic and adipogenic precursors, highlighted the critical role of CACNA2D2 in regulating myogenic differentiation, and illustrated the possible regulatory ways of DNA methylation on cell fate commitment and skeletal muscle homeostasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-020-02053-3.…”
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“…INTRODUCTION: The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. …”
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“…Results include improved processes that instil confidence. ‘Committing to patient involvement as part of HTA culture’ highlights several initiatives aimed at changes in HTA organisational culture to be more inclusive of patients. …”
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“…Most pharmaceutical companies commit a great deal of time and money to market in hopes of convincing physicians about their products. …”
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“…The challenges could be addressed by conducting a transition readiness assessment, identifying health sector priorities, developing a transition plan with a budget to continue critical health programmes and mobilising greater political commitment to health. The loss of aid could be turned into an opportunity to integrate vertical programmes into a more comprehensive health system.…”
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“…They acknowledged the curriculum as a commitment to wellness and felt it reduced burnout and improved empathy. …”
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“…This study demonstrates that committing to emergency care can potentially have large effects on reducing mortality.…”
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“…Methods In this paper, a Susceptible-Exposed-Infected-Removed model is described in terms of probabilistic cellular automata and ordinary differential equations for the transmission of COVID-19, flexible enough for simulating different scenarios of social isolation according to the following features: the start day for the social isolation after the first death, the period for the social isolation campaign, and the percentage of the population committed to the campaign. Results Results showed that efforts in the social isolation campaign must be concentrated both on the isolation percentage and campaign duration to delay the healthcare system failure. …”
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“…Finally, we show that the commitment to enhanced memory within Nr2f6-deficient OT-I T cells is established in the early phases of the antibacterial immune response and is IFN-γ mediated. …”
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“…CONCLUSION: Although the MAS has faced numerous obstacles, it has been possible to continue a longitudinal research project throughout the humanitarian crisis, because our research team has engaged the community deeply and developed a sense of mutual commitment, and also because our project has provided funding to help keep researchers employed, somewhat attenuating the brain drain.…”
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“…Concerns were raised about the impact of foreign investment on the diversity of the domestic cannabis sector in Jamaica, including the commitment to transition traditional illegal small-scale cannabis cultivators to the legal sector. …”
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“…Relevant content coded under these salient domains were categorised into seven key themes: unclear expectations of trial participation, personal attributes for questionnaire return, commitment to returning questionnaires given other priorities, sources of support in returning the questionnaires, individual preferences for presentation mode and timing of the questionnaires, internal and external strategies to encourage questionnaire return and the significance of questionnaire non-return. …”
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“…Restimulation-induced cell death (RICD) is one such mechanism where by activated T cells receive subsequent antigenic stimulation, reach a critical signal threshold through the T cell receptor (TCR), and commit to apoptosis. Many details of this process remain unclear, including the role of co-stimulatory and co-inhibitory proteins that influence the TCR signaling cascade. …”
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“…Functional analysis demonstrates that the lncRNA pairs in SepsigLnc are functionally similar and tend to implicate in the same biological processes including cell fate commitment and cellular response to steroid hormone stimulus. …”
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“…RESULTS: We identified the transcription factors and epigenomic changes in chromatin that are associated with differentiation of POU1F1-expressing progenitors into thyrotropes using cell lines that represent an undifferentiated Pou1f1 lineage progenitor (GHF-T1) and a committed thyrotrope line that produces TSH (TαT1). …”
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