“…We demonstrate that NSCs are unique among precursor cells in the uneven partitioning of genetic material during cell divisions.…”
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“…The curve relating flash energy and pupil response was clearly divisible into two parts commensurate with the duplex character of the human retina. …”
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“…In the initial embryonic divisions, Wolbachia segregate asymmetrically such that they occupy only a small subset of cells in the developing embryo, facilitating their concentration in the adult hypodermal chords and female germline. …”
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“…This means that each cell type contains a specific epigenetic program that needs to be replicated through cell divisions, along with the genome, in order to maintain cell identity. …”
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“…Our findings support a role for a domain-general resource in models of working memory, and furthermore suggest that this resource is flexibly divisible.…”
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“…We use the protein-coding gene CAD and 28S rDNA to determine phylogeny and to test the monophyly of existing subfamilies, the divisions Tomophtalmae, and ‘the sand chamber subfamilies’. …”
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“…However, a simple computational framework that accounts for these empirical features of multisensory integration has not been established. We propose that divisive normalization, acting at the stage of multisensory integration, can account for many of the empirical principles of multisensory integration exhibited by single neurons, such as the principle of inverse effectiveness and the spatial principle. …”
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“…Increased commitment was caused by reduced symmetric self-renewal and increased symmetric differentiation divisions of Satb1-deficient HSCs. Satb1 simultaneously repressed gene sets involved in HSC activation and cellular polarity, including Numb and Myc, two key factors for stem cell fate specification. …”
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“…More specifically, we observed the existence of phage carrier cells harboring an episomal P22 element that segregated asymmetrically upon subsequent divisions. Moreover, a newly discovered P22 ORFan protein (Pid) able to derepress a metabolic operon of the host (dgo) proved to be specifically expressed in these phage carrier cells. …”
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“…Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. …”
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“…Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. …”
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“…Our analyses revealed highly diverse entire colonization profiles, spread into 8 phyla/candidate divisions and in 15 different bacterial classes. A large inter-individual difference in the subjects’ microbiota was observed, comprising 35% of the total variance, but lacking conspicuous general temporal trends in both alpha and beta diversity. …”
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“…This effect will be especially strong in organisms that have large numbers of cell divisions between generations. This shows the necessity of going beyond phylogeny and integrating its study with other properties of organisms.…”
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“…It utilises this evidence to produce new estimates of the probable prevalence of syphilis among adult males, both nationally and among certain geographical divisions and social groups in the national population; and also to offer a comment on the likely prevalence of gonorrhoea.…”
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“…This should ease the tracking of cell shape, cell divisions and tagged proteins over long periods of time.…”
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“…It is found that the FPÖ has weakened Austria’s previously highly stable system of socio-structural and ideological divisions as expressed by the two mainstream parties, the People’s Party and the Social Democrats. …”
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“…Yet that promising biomedical advent was superseded for more than a half-century by deep, internal divisions and bitter rifts that festered between three medical disciplines: neurology; Freudian psychotherapy; and Kraepelinian biological psychiatry. …”
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“…Larger organisms tend to live longer, have more potentially carcinogenic cells, and undergo more cell divisions. While one might intuitively expect cancer incidence to scale with body size, this assertion does not hold over the range of different mammals. …”
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“…Three conditions are required: a circumferential location of stem cells, a limited number of cell divisions and mobility in response to population pressure. …”
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“…The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcription. …”
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