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  1. 36941
    “…This suggests that the majority of Lgr5-positive cell divisions serve to renew epithelial cells and only few result in the effective replacement of a neighbour to effect expansion to the entire gland. …”
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    Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium
  2. 36942
    “…The LHb contains two anatomically and functionally distinct regions: lateral (LHbl) and medial (LHbm) divisions. We compared serotonin’s effects on glutamatergic transmission across the LHb in rat brains. …”
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    Serotonin modulates glutamatergic transmission to neurons in the lateral habenula
  3. 36943
    por Kurhekar, Manish, Deshpande, Umesh
    Publicado 2016
    “…This model incorporates stem cell death (apoptosis) after a certain number of cell divisions and also demonstrates that a single HSC can potentially populate the entire bone marrow. …”
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    Agent-Based Deterministic Modeling of the Bone Marrow Homeostasis
  4. 36944
    por Tsichlaki, Elina, FitzHarris, Greg
    Publicado 2016
    “…Controlling nucleus size is a particular challenge in early development, where the nucleus must downscale in size with progressive reductive cell divisions. Here we use live and fixed imaging, micromanipulation approaches, and small molecule analyses during preimplantation mouse development to probe the mechanisms by which nucleus size is determined. …”
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    Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs
  5. 36945
    “…This result suggests that either mammary epithelial stem cells maintain their telomere length in order to self renew, or that the absence or reduction of telomerase template results in more frequent death/extinction of stem cells during symmetric divisions. A third possibility is the inability of signaling cells in the niche to replicate resulting in reduction of the maintenance signals necessary for stem cell renewal. …”
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    Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for “reprogramming” neural stem cells
  6. 36946
    “…Within Japan, the inter-regional differences for both isotope ratios was less than 1‰, which indicates low dietary heterogeneity among prefectural divisions. The carbon and nitrogen isotope ratios of the hair showed a significant correlation with the results of questionnaires on self-reported dietary habits. …”
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    Homogeneous diet of contemporary Japanese inferred from stable isotope ratios of hair
  7. 36947
    “…When we force expression of IME1 from an inducible promoter in cells incubated in sporulation medium for 2 hr, the vast majority of cells exhibit synchrony during premeiotic DNA replication and meiotic divisions. Inducing IME1 expression too early or too late affects the synchrony of sporulation. …”
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    Temporal Expression of a Master Regulator Drives Synchronous Sporulation in Budding Yeast
  8. 36948
    “…Furthermore, LIN-23, the C. elegans β-TrCP ortholog, appears to function as a repressor of CDC-25.2 to prevent excess intestinal divisions. We previously reported that intestinal hyperplasia in lin-23(e1883) mutants was effectively suppressed by the RNAi depletion of cdc-25.2. …”
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    LIN-23, an E3 Ubiquitin Ligase Component, Is Required for the Repression of CDC-25.2 Activity during Intestinal Development in Caenorhabditis elegans
  9. 36949
    por Mohandoss, Anusa Arunachalam
    Publicado 2016
    “…As only whole sum numbers associated with state, age groups, and genders and years were only available parameters, descriptive statistics of rate of suicides, linear trend with age groups, gender, and geographical divisions are presented. RESULTS: In 14 years period, 1,721,946 suicides with an average of 122,996 suicides per year were observed. …”
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    Ideological Cause and Hero Worship Related Suicides: Indian Perspective and Changing Trends During 2001–2014: An Exploratory Study
  10. 36950
    “…We first performed a partial hepatic parenchymal transection to expose the hilar plate, and then transected the proximal bile duct to confirm margin status. Then, divisions of the hepatic artery and portal vein of the future resected liver are performed, followed by the residual hepatic parenchymal transection. …”
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    Transhepatic Hilar Approach for Perihilar Cholangiocarcinoma: Significance of Early Judgment of Resectability and Safe Vascular Reconstruction
  11. 36951
    “…BACKGROUND: Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory. …”
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    The architecture of chicken chromosome territories changes during differentiation
  12. 36952
    “…Therefore, dedicated plasmid maintenance systems have evolved, leading to plasmid loss rates as low as 1 per 10(7) divisions. These low rates complicate studies of plasmid loss, as traditional techniques for measuring plasmid loss are laborious and not quantitative. …”
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    Direct and convenient measurement of plasmid stability in lab and clinical isolates of E. coli
  13. 36953
    “…Containing thirty-two candidate divisions and possibly undocumented prokaryotic lineages, the hypersaline sapropels were found to accommodate one of the most diverse and novel ecosystems reported to date and may contribute to completing the phylogenetic branching of the tree of life.…”
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    Hypersaline sapropels act as hotspots for microbial dark matter
  14. 36954
    “…These epigenetic modifications are less stable than genetic alterations and even reversible under a variety of circumstances, such as developmental changes, regeneration of tissues, cell divisions, aging, and pathological conditions observed in many cancers. …”
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    The interplay between epigenetic changes and the p53 protein in stem cells
  15. 36955
    “…This reduction in chromosome number occurs through two highly asymmetric cell divisions, resulting in one large egg and two small polar bodies. …”
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    A casein kinase 1 prevents expulsion of the oocyte meiotic spindle into a polar body by regulating cortical contractility
  16. 36956
    “…The changes in pectin distribution took place when periclinal divisions appeared within a procambial trace. The distribution difference of pectin epitopes was also present in procambium–cambium derivatives. …”
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    Dynamic Changes of Pectin Epitopes in Cell Walls during the Development of the Procambium–Cambium Continuum in Poplar
  17. 36957
    “…Spermatogenesis is a dynamic developmental process that includes stem cell proliferation and differentiation, meiotic cell divisions and extreme chromatin condensation. Although studied in mice, the molecular control of human spermatogenesis is largely unknown. …”
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    Unraveling transcriptome dynamics in human spermatogenesis
  18. 36958
    “…Next, genetic relationships along administrative and ethnic divisions were analyzed using pairwise genetic distances, multidimensional scaling (MDS), principal component analysis (PCA) and phylogenetic analysis. …”
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    Genetic characteristics and phylogenetic analysis of three Chinese ethnic groups using the Huaxia Platinum System
  19. 36959
    “…We found that Drosophila Mms19 is also essential for mitotic divisions and for the proliferation of diploid cells. …”
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    Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase
  20. 36960
    “…Conscious and differential choices of the R&D and business models for different companies and different divisions in the same company seem to best allow a company to fully exploit the potential of both internal and external innovations.…”
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    Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making?
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