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  1. 36961
    “…Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. …”
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    Telomere Maintenance Mechanisms in Cancer
  2. 36962
    “…Knock-down of Spindly in the female germ line results in mitotic arrest during embryonic cleavage divisions. We investigated the requirements of Spindly protein domains for its localisation and function, and found that the carboxy-terminal region controls Spindly localisation in a cell-type specific manner. …”
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    Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila
  3. 36963
    por Bornens, Michel
    Publicado 2018
    “…Metazoans are unique in making cohesive multicellular organisms through complete cell divisions. They evolved a primary cilium/centrosome (PC/C) organ, ensuring similar functions to the basal body/flagellum of unicellular eukaryotes, but in different cells, or in the same cell at different moments. …”
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    Cell polarity: having and making sense of direction—on the evolutionary significance of the primary cilium/centrosome organ in Metazoa
  4. 36964
    por Tomita, Kazunori
    Publicado 2018
    “…Telomere length homeostasis is achieved via a balance between telomere lengthening by telomerase, and erosion over successive cell divisions. Impaired telomerase regulation leads to shortened telomeres and can cause defects in tissue maintenance. …”
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    How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis
  5. 36965
    “…In short, alcohol transiently reduces reactivity to emotional faces and it does so similarly across the two major divisions of the human EAc. These observations reinforce the translational relevance of addiction models derived from preclinical work in rodents and provide new insights into the neural systems most relevant to the consumption of alcohol and to the initial development of alcohol abuse in humans.…”
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    Acute alcohol administration dampens central extended amygdala reactivity
  6. 36966
    “…While PIF1 deletion rescues the lethality of Dna2 depletion, RAD9 ablation relieves the first cell cycle arrest causing genotoxicity after few cell divisions. Slow fork speed attenuates DDR in Dna2 deprived cells. …”
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    Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement
  7. 36967
    “…Categories describe semantic divisions between classes of objects and category-based models are widely used for investigation of the conceptual system. …”
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    Temporal dynamics of access to amodal representations of category-level conceptual information
  8. 36968
    “…Here, we show that female mice genetically ablated for cyclin B3 are viable—indicating that the protein is dispensable for mitotic divisions—but are sterile. Mutant oocytes appear normal until metaphase I but then display a highly penetrant failure to transition to anaphase I. …”
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    Cyclin B3 promotes anaphase I onset in oocyte meiosis
  9. 36969
    “…Here we observed BMSC colony formation in real time via time lapsed optical imaging and analysis, to quantify whether and how heterogeneity emerged over multiple cell divisions spanning the duration of a typical colony formation unit assay. …”
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    Emergent heterogeneity in putative mesenchymal stem cell colonies: Single-cell time lapsed analysis
  10. 36970
    “…DNA methylation is an epigenetic mechanism which is both sensitive to environmental conditions and stably inherited across cell divisions. We therefore investigate early life predisposition in the round goby Neogobius melanostomus by growth back-calculations and then study DNA methylation by MBD-Seq in the brain region controlling vertebrate reproductive behavior, the hypothalamus. …”
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    DNA Methylation Patterns in the Round Goby Hypothalamus Support an On-The-Spot Decision Scenario for Territorial Behavior
  11. 36971
    “…Our findings have implications for political polarization and social learning in the midst of political divisions.…”
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    Epistemic spillovers: Learning others’ political views reduces the ability to assess and use their expertise in nonpolitical domains
  12. 36972
    “…The CLRs persist through the meiotic divisions and are inherited by young spermatids. During spermatid differentiation the ciliary caps elongate giving rise to the sperm axoneme. …”
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    The Microtubule-Depolymerizing Kinesin-13 Klp10A Is Enriched in the Transition Zone of the Ciliary Structures of Drosophila melanogaster
  13. 36973
    “…Taken together, these results suggest there is potential to expand the neural distance-to-bound approach to other divisions beyond animacy and object category.…”
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    Using neural distance to predict reaction time for categorizing the animacy, shape, and abstract properties of objects
  14. 36974
    “…Faithful chromosome segregation is required for both mitotic and meiotic cell divisions and is regulated by multiple mechanisms including the anaphase‐promoting complex/cyclosome (APC/C), which is the largest known E3 ubiquitin‐ligase complex and has been implicated in regulating chromosome segregation in both mitosis and meiosis in animals. …”
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    The Arabidopsis anaphase‐promoting complex/cyclosome subunit 8 is required for male meiosis
  15. 36975
    por Atashgahi, Siavash
    Publicado 2019
    “…Further analysis showed that the hybrid putative rdh genes are present in the genomes of pure cultures and uncultured members of Bacteriodetes and Deltaproteobacteria, but also in the genomes of the candidate divisions. The encoded hybrid putative RDases have cytoplasmic or exoplasmic C-terminus localization, and cluster phylogenetically separately from the existing RDase groups. …”
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    Discovered by genomics: putative reductive dehalogenases with N-terminus transmembrane helixes
  16. 36976
    “…At the epicenter of these divisions lies conflicting neuropsychological findings. …”
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    Characterizing memory loss in patients with autoimmune limbic encephalitis hippocampal lesions
  17. 36977
    “…Intracontinental biotic divisions across the vast Palaearctic region are not well-characterized. …”
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    Population genomics of two congeneric Palaearctic shorebirds reveals differential impacts of Quaternary climate oscillations across habitats types
  18. 36978
    por Kato, Ryo, Okada, Motohiro
    Publicado 2019
    “…Therefore, to explore the effects of governmental financial support on suicide mortality rates in Japan, the present study determined the relationship between the trends of empirical Bayes standardised Mobile Ratio of suicide mortality ratio in all 47 Japanese prefectures (EBSMR-RR) and the execution amounts of 10 sub-divisions of ‘Emergency Fund to Enhance Community-Based Suicide Countermeasure’ using stepwise multiple regression analysis. …”
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    Can Financial Support Reduce Suicide Mortality Rates?
  19. 36979
    “…After injecting CTB into the secondary auditory field (A2), we found densely innervated CTB-positive axon terminals that were mainly located in the lateral amygdala (La), and slight innervations in other divisions such as the basal amygdala. Moreover, we found a large number of retrogradely-stained CTB-positive neurons in La after injecting CTB into A2. …”
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    Reciprocal connectivity between secondary auditory cortical field and amygdala in mice
  20. 36980
    “…Classically, it has been linked to critical telomere curtailment following repetitive cell divisions, and later described as a response to oncogenes and other stressors. …”
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    Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process
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