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  1. 355441
    “…A standard clinical questioning data module, virtual case data module, and student learning difficulty module are established to achieve simulation. Students can view the objective examination and inspection data of actual cases, including details of the consultation and physical examination, and automatically provide their learning response via a multi-dimensional evaluation system. …”
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    Intelligent virtual case learning system based on real medical records and natural language processing
  2. 355442
    “…Participants were provided 2 months of access to a mobile app called Wysa, which is an established, multicomponent digital mental health intervention that uses chatbot technology and text-based access to human counselors to deliver cognitive behavioral therapy, mindfulness training, and sleep tools, among other features. …”
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    A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study
  3. 355443
    “…Future studies should evaluate the blink reflex as a clinical biomarker to predict treatment response at baseline and to establish the risk of relapse after treatment discontinuation. …”
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    Preventive treatment with CGRP monoclonal antibodies restores brain stem habituation deficits and excitability to painful stimuli in migraine: results from a prospective case-control study
  4. 355444
    “…RESULTS: Among 108 participants with SARS-CoV-2–positive PCR findings, 57 were children (35 boys [61.4%]; median age, 4 [IQR, 2-10] years) and 51 were adults (28 women [54.9%]; median age, 37 [IQR, 34-45] years). Using the 3 established serological assays, a lower proportion of children had seroconversion to IgG compared with adults (20 of 54 [37.0%] vs 32 of 42 [76.2%]; P < .001). …”
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    Comparison of Seroconversion in Children and Adults With Mild COVID-19
  5. 355445
    “…Immune response to mRNA-1273 vaccination across multiple cancer types and treatments remains to be established. OBJECTIVE: To quantitate antibody responses after mRNA-1273 vaccination among patients with solid tumors and hematologic cancer and to assess clinical and treatment factors associated with vaccine response. …”
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    Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida
  6. 355446
    “…However, staff and clinicians both reported that the virtual visit format limited the quality of the assessment and the ability to respond rapidly in situations of passive suicidal ideation, especially when this ideation did not meet the threshold for clinician notification specified in the in-person protocol.  Thus, we established the need for a specific virtual suicide risk assessment protocol. …”
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    Developing a New Suicide Risk Assessment for Virtual Encounters with Non-Clinicians
  7. 355447
    “…However, no reliable method for measuring P(ET)CO(2) during noninvasive ventilation (NIV) has been established. The purpose of this study was to evaluate the correlation and agreement between PaCO(2) and P(ET)CO(2) measured by these two methods and to compare them in patients who underwent NIV after extubation. …”
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    Accuracy evaluation of mainstream and sidestream end-tidal carbon dioxide monitoring during noninvasive ventilation: a randomized crossover trial (MASCAT-NIV trial)
  8. 355448
    “…We analyzed pooled safety results from three phase 3 IV golimumab trials in these rheumatologic diseases and hypothesized that the safety profile of IV golimumab would be similar to that established for other TNFi, including subcutaneous golimumab. …”
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    Pooled safety results across phase 3 randomized trials of intravenous golimumab in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
  9. 355449
    “…CONCLUSIONS: Interventions to promote dog walking may benefit from increasing intention to dog walk in male owners, forming schedules and routines that involve multiple household members in dog walking, and establishing habits around dog walking. Interventions may also need to address how to overcome barriers and perceived challenges in regards to self-efficacy of dog walking, that may prevent intention from being translated into action.…”
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    A cross-sectional study of factors associated with regular dog walking and intention to walk the dog
  10. 355450
    “…At the end, a circRNA-miRNA-mRNA regulatory axis was established for five final selected hub genes. This study implies the potential pathogenesis of the obtained network and proposes that the two DECs (has_circ_0070934 and has_circ_0004315) may be important prognostic markers for HCC.…”
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    Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis
  11. 355451
    “…The association of neighborhood-level socioeconomic status (SES) with cognition and dementia risk is not well known, particularly in midlife when late-life dementia may still be preventable through established interventions, such as blood pressure management. …”
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    Association of Neighborhood-Level Socioeconomic Measures With Cognition and Dementia Risk in Australian Adults
  12. 355452
    “…However, on adjustment for baseline BMI only four CpG sites remained genome-wide significant, and addition of the 76 CpG methylation risk score to a prediction model including established predictors of type 2 diabetes (age, sex, BMI and HbA(1c)) showed no improvement (AUC 0.757 vs 0.753). …”
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    Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts
  13. 355453
    “…A nationwide primary care-based LTBI testing and treatment programme for migrants from high-incidence countries was therefore established in high tuberculosis incidence areas in England. …”
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    Effectiveness of nationwide programmatic testing and treatment for latent tuberculosis infection in migrants in England: a retrospective, population-based cohort study
  14. 355454
    “…METHODS: We proposed a 2-stage detection system. First, we established the region localization stage to automatically locate specific detection regions of raw 2D DSA sequences. …”
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    Using a Convolutional Neural Network and Convolutional Long Short-term Memory to Automatically Detect Aneurysms on 2D Digital Subtraction Angiography Images: Framework Development and Validation
  15. 355455
    “…A hACE2 mouse model of novel SARS-CoV-2 pneumonia was established. Survival rates, histological changes, inflammatory markers, lung virus titers and the expression of the key proteins in the NF-κB/MAPK signaling pathway was detected by western blotting and immumohistochemical staining in the lungs were measured. …”
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    Liushen Capsules, a promising clinical candidate for COVID-19, alleviates SARS-CoV-2-induced pulmonary in vivo and inhibits the proliferation of the variant virus strains in vitro
  16. 355456
    “…Consideration needs to be given to addressing limited access to transport and flexible operating hours when establishing similar services. GRAPHICAL ABSTRACT: [Image: see text] Artist Jenni McEwen (Bundjalung) lives on Darkinjung Country. …”
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    Yarning about foot care: evaluation of a foot care service for Aboriginal and Torres Strait Islander Peoples
  17. 355457
    “…METHODS: NHS Highland (NHSH) frontline staff volunteers (N=169) were randomly assigned to the newly developed NHSH Staff Wellbeing Project (NHSWBP), an established digital intervention (My Possible Self [MPS]), or a waitlist (WL) group for 4 weeks. …”
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    Brief Digital Interventions to Support the Psychological Well-being of NHS Staff During the COVID-19 Pandemic: 3-Arm Pilot Randomized Controlled Trial
  18. 355458
    “…This review seeks to serve as a valuable resource for the SCI community by establishing a rigorous and unbiased description of miRNA changes after SCI for the next generation of SCI biomarkers and therapeutic interventions. …”
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    Spinal cord injury: a study protocol for a systematic review and meta-analysis of microRNA alterations
  19. 355459
    “…METHODS: The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-α-induced MMP-9 protein overexpression to evaluate the anti-inflammatory effects of quercetin. …”
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    Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells
  20. 355460
    “…BACKGROUND: The importance of patient-reported outcome measurement in chronic kidney disease (CKD) populations has been established. However, there remains a lack of research that has synthesised data around CKD-specific symptom and health-related quality of life (HRQOL) burden globally, to inform focused measurement of the most relevant patient-important information in a way that minimises patient burden. …”
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    Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis
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