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  1. 356281
    “…Well‐designed RCTs, or large prospective cohort studies, comparing six months with longer treatment regimens with long follow‐up periods established at initiation of ATT are needed to resolve the uncertainty regarding the safety and efficacy of six months regimens for TBM. 2 April 2019 Up to date All studies incorporated from most recent search All eligible published studies found in the last search (31 Mar, 2016) were included and one ongoing study was identified (see 'Characteristics of ongoing studies' section)…”
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    Six months therapy for tuberculous meningitis
  2. 356282
    “…It is therefore important at this stage to establish the efficacy and safety of these programmes, and furthermore to address the critical factors that determine their success or failure. …”
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    Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
  3. 356283
    “…However, we did not establish a correlation between the down-regulated CD3+CD69+ cells and the clinical subset, nor regarding the stage of the disease. …”
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    Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients
  4. 356284
    por McKee, Natalie, McHenry, Michelle
    Publicado 2019
    “…The persistence of effusion was likely on the basis of RA, and establishing that this was the driving factor once infection/ other aetiology was excluded led to re-evaluation regarding biologic therapy with multi-specialty input. …”
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    12. Dramatic improvement of chronic pleural effusion with abatacept treatment in longstanding rheumatoid arthritis, after chest sepsis during treatment with anti-TNF-α
  5. 356285
    “…Particularly in the context of a suspected infection, an extensive travel and social history is important in establishing risk of exposure to pathogens either directly or indirectly via vectors. …”
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    17. Tick-borne relapsing fever: a fever syndrome mimic
  6. 356286
    “…The leaders returned to their hospitals, established a multidisciplinary committee and started auditing maternal deaths, with the support of external facilitators. …”
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    Death audits and reviews for reducing maternal, perinatal and child mortality
  7. 356287
    por Bitat, Syed Rabha
    Publicado 2020
    “…The exact pathophysiologic mechanism and predictive biomarkers have not yet been established. The end result is permanent Insulin dependence. …”
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    MON-LB121 New Onset Insulin Dependent Diabetes Mellitus Secondary to Treatment With Immune Checkpoint Inhibitor
  8. 356288
    “…MAIN OUTCOMES: If the patient requires ambulatory observation, according to the protocol established in this respect in the Emergency Department, meets all the criteria for inclusion and none for exclusion, data will be taken by the person responsible on the data collection sheet. …”
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    Outpatient treatment of COVID-19 with steroids in the phase of mild pneumonia without the need for admission as an opportunity to modify the course of the disease: A structured summary of a randomised controlled trial
  9. 356289
    “…Multicomponent interventions, which can include phase-based approaches, were the most effective treatment package for managing PTSD in complex trauma. Establishing optimal ways to deliver multicomponent psychological interventions for people exposed to complex traumatic events is a research and clinical priority.…”
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    Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis
  10. 356290
    “…Here we report regional differences in clinical outcomes of severe COVID-19 patients treated with RDV, as part of an open-label, randomized phase-3 trial establishing RDV treatment duration. METHODS: Hospitalized patients with oxygen saturation ≤94%, a positive SARS-CoV-2 PCR in the past 4 days and radiographic evidence of pneumonia were randomized 1:1 to receive 5d or 10d of intravenous RDV. …”
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    73. Geographical Disparities in Clinical Outcomes of Severe COVID-19 Patients Treated with Remdesivir
  11. 356291
    “…Further research is justified to establish if nebulised heparin accelerates recovery in those who have or are at risk of ARDS. …”
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    Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
  12. 356292
    por Martínez, Pilar, Palanques Pastor, Tomás, Lopez Lorenzo, Jose Luiz, Cornago Navascués, Javier, Rodriguez-Macías, Gabriela, Cano, Isabel, Arnan Sangerman, Montserrat, Vidriales, María-Belén, Algarra, Jesús Lorenzo, Foncillas, Maria Angeles, Herrera Puente, Pilar, Botella, Carmen, Vives, Susana, Figuera Alvarez, Angela, Cuevas Palomares, Laida, Sobas, Marta, Contento-Gonzalo, Alejandro, Cuello, Rebeca, Amutio Diez, María Elena, De Miguel, Maria Dunia, Navas, Begoña, Bergua Burgues, Juan Miguel, Bernal del Castillo, Teresa, Mateos Rodríguez, María Carmen, de Cabo López, Erik, Franco Villegas, Ana Carolina, García-Boyero, Raimundo, Escolano Escobar, Cristian, Seri, Cristina, Cervero, Carlos, Roldán Pérez, Alicia, Hermosin, Maria Lourdes, Cervera, Marta, Olave, María Teresa, Villafuerte Gutierrez, Paola Sandra, De Laiglesia, Almudena, Serrano, Josefina, Najera Irazu, María Josefa, Piñana Sanchez, Jose Luis, Sanz, Miguel Ángel, Martinez-Lopez, Joaquin, Montesinos, Pau
    Publicado 2020
    “…In 48.1% of the cases treatment for AML was maintained, in 26.6% delayed and in 25.3% modified due to coronavirus disease.47.5% died, establishing an association between mortality and age over 60 years (58.3% vs 36.4%, p=0.043), ≥2 lines of treatment (72.7% vs 44.3%, p=0.020), active disease (62.5% vs 29.4%, p=0.002) and pneumonia (61.2% versus 22.7%, p=0.002). …”
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    Impact of Sars-Cov-2 Infection in Acute Myeloid Leukemia Patients: Experience of the Pethema Registry
  13. 356293
    “…OBJECTIVES: The objective of this review is to establish whether or not existing school‐based antibullying programs are effective in reducing school‐bullyng behaviors. …”
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    Effectiveness of school‐based programs to reduce bullying perpetration and victimization: An updated systematic review and meta‐analysis
  14. 356294
    “…Non-inferiority of follitropin delta in its individualised dosing regimen to conventional follitropin alfa was established with respect to the primary endpoint of ongoing pregnancy rate which was 31.3% with follitropin delta compared to 25.7% with follitropin alfa (estimated mean difference 5.4% [95% CI: −0.2%; 11.0%]). …”
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    A randomised controlled trial to clinically validate follitropin delta in its individualised dosing regimen for ovarian stimulation in Asian IVF/ICSI patients
  15. 356295
    “…At the same time, shared vaccination ideas and practices helped some parents establish social relationships, which in turn strengthened their views and practices around vaccination. …”
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    Factors that influence parents' and informal caregivers' views and practices regarding routine childhood vaccination: a qualitative evidence synthesis
  16. 356296
    “…Methods: Two self-reported assessment tools were used, with options of English or Spanish: 1) PROMIS® pediatric (8a, v1.0) or adult (4a, v1.0) depression measures, completed at HABIT enrollment, nearly all between May 2018 - March 2020 (“baseline”); 2) A pandemic-related open-access survey originated by Johns Hopkins University on established core adult mental health assessed risks and behaviors.[1] Questions were closely adapted for use by youth. …”
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    Mental Health Assessment of Youth with Sickle Cell Disease and Their Primary Caretakers: Baseline Depression and COVID-19 Pandemic-Associated Psychosocial Stress in a Multi-Site Study
  17. 356297
    “…A strategy to mitigate risks associated with COVID-19 was established at LCI in partnership with Atrium Health's (AH) Hospital at Home (HAH). …”
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    Platform Incorporating Patient Navigation, Preparative Guidelines, and Hospital at Home May Improve COVID-19 Outcomes for Patients with Myeloid Malignancies
  18. 356298
    “…The immunogenicity of the COVID-19 vaccines in patients with exposure to CD19 directed Chimeric Antigen Receptor (CAR)-T cell therapy is not established. CD19 CAR-T cell therapies cause B-cell aplasia, which in turn can affect humoral immune response against novel antigens. …”
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    Impaired mRNA Based COVID-19 Vaccine Response in Patients with B-Cell Malignancies after CD19 Directed CAR-T Cell Therapy
  19. 356299
    por Bader, Mohamed, Al-Hassani, Hayder
    Publicado 2021
    “…ECG completion rate of 31%, despite being low, represents a significant improvement as the team did not have an ECG machine prior to the audit. Establishing a baseline ECG would also be of clinical value even if normal, as it would allow for future comparisons of QTc intervals compared to pre-treatment baselines. …”
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    Physical health audit of gwent specialist substance misuse services (North Team)
  20. 356300
    “…We report a case of orbital mucosa-associated lymphoid tissue (MALT) lymphoma in a patient with established rheumatoid arthritis with secondary Sjogren’s syndrome with quiescent disease treated with methotrexate and etanercept for many years. …”
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    O04 Orbital lymphoma in a 72-year-old lady with rheumatoid arthritis: an argument for rituximab
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