“…In the last five years, significant advances have progressed the structural and functional understanding of PARP1-3, such as understanding allosteric activation via inter-domain contacts, how PARP senses damaged DNA in the crowded nucleus, and the complementary role of histone PARylation factor 1 in modulating the active site of PARP. …”
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“…Almost all participants reported that they avoid crowded places frequently. About 93.4% of the participants declared frequently wearing face mask when leaving home, and 85.5% maintained social distancing frequently. …”
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“…Natural stimuli typically possess crowded, spectrally dense, dynamic, and multimodal properties within a rich multiscale structure. …”
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“…Moreover, they avoided crowded or shared spaces by reducing bus trips and trips toward commercial areas. …”
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“…Herein, a programmable pathway is established to exploit a simple chemistry to construct structural transition of protocell models from emulsion droplets, nanocapsules to molecularly crowded droplets. The transitional process toward distinct cell‐like compartments is driven by interfacial self‐assembly of simple components and regulated by physicochemical cues (e.g., mechanical force, solvent evaporation, acid/base equilibrium) triggered dynamic covalent chemistry. …”
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“…As the research space for higher incidence malignancies became increasingly crowded, attention has turned towards those malignancies with lower incidence. …”
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“…Considering the other anomalies, crowding was one of the most frequent with a prevalence of up to 84%, followed by spacing, which reached a frequency of 60%. …”
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“…Moreover, this effect mainly comes from the crowding-out effect of imported intermediate goods on domestic intermediate goods. …”
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“…For the weakly confined polymers, in compression process, the flexible linear polymer collapses into condensed states under a small external force, whereas the ring polymer only shows slight shrinkage, due to the excluded volume interactions of two strands in the crowded states. These results are essential for understanding the deformations of the ring biomacromolecules and polymer chains in mechanical compression or driven transport.…”
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“…After reviewing the simulation results, it was concluded that under the impacts of both sudden incident and peak passenger flow, the more the passengers coming from platform inlets, the longer the non-incidental line platform total train operation delay and the higher the crowding degree. However, train headway has little influence on non-incidental line platform risk development. …”
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“…Most interestingly, in membrane-mimicking solution, the Cu(II) affinities of amylin analogues are lower than the ones in water, probably due to the crowding effect of the membrane solution and the fact that amide coordination occurs at higher pH, which happens most likely because the α-helical structure, imposed by the membrane-mimicking solvent, prevents the amides from binding at lower pH, requiring a local unwinding of the α-helix.…”
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“…In our daily routine, the use of a face (surgical) mask is necessary, especially in public places, to prevent the spread of this disease. Furthermore, in crowded indoor areas, the automated recognition of people wearing a mask is a requisite for the assurance of public health. …”
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“…We show that MeCP2 alone forms liquid-like spherical droplets via multivalent electrostatic interactions and with isotropic mobility. Crowded environments and DNA promote MeCP2 LLPS and slow down MeCP2 mobility. …”
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“…The internal environment of cells is molecularly crowded, which requires spatial organization via subcellular compartmentalization. …”
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“…On non-planar membranes, Snf7 monomers are curvature insensitive, but Snf7-spirals selectively adapt their conformation to membrane geometry. In a non-crowded system, Snf7-spirals reach a critical radius, and remodel to minimize internal stress. …”
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“…The results show that women's feeling of not being safe in the urban space of Tehran, the capital of Iran, is the result of some influential structural factors such as “socioeconomic challenges” and “dysfunctional socialization” and some contextual factors such as “crowded places” and “showing off.” The women in the study also believe that their feelings of unsafety are reinforced by certain reasons evident in the behavior, language, and gestures of men. …”
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“…However, the mechanisms underlying the identification and approach of X chromosome pairs in the crowded nucleus are unclear. To elucidate the driving force of Xic pairing, we developed a coarse-grained molecular dynamics model of intranuclear chromosomes in ES cells and in cells 2 days after the onset of differentiation (2-day cells) by considering intrachromosomal epigenetic-structural feature-dependent mechanics. …”
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“…We found that these cells feature several hallmarks of amoeboid-like migration that enable them to tailor their movements to the spatial constraints of the crowded retina. These hallmarks include cell and nuclear shape changes, as well as persistent rearward polarization of stable F-actin. …”
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“…Their needs may be diverse, with priority for the shortest path, the less crowded or the less polluted one, the accessibility for reduced mobility, or the sheltering from unfavorable weather conditions. …”
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“…The test consists of two cards with five contorted lines of increasing overlap, crowding, and difficulty. The task starts from each of the letters at the top of the page, follows the line from the letter to the corresponding number at the bottom of the page, and the number is named. …”
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