“…Supported by mathematical modeling, we demonstrate that organelle exclusion by a membrane system causes spatio-temporal differences in molecular crowding states that are sufficient to drive accumulation of mitotic regulators, such as Mad2 and Megator/Tpr, as well as soluble tubulin, in the spindle region. …”
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“…We see GHERG as an informal and entirely voluntary international collaboration of academic groups who are willing to contribute to improving disease burden estimates and respect the principles of the new guidelines – a form of “academic crowd–sourcing”. The main focus of GHERG will be to identify the “gap areas” where not much information is available and/or where there is a lot of uncertainty present about the accuracy of the existing estimates. …”
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“…Following gestational crowding of mouth brooding mothers, we saw differential methylation and transcription of GnRH1 in their offspring. …”
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“…Compounding the challenges of delivering timely emergency care are the known delays caused by ED crowding. However, the association of ED crowding with timeliness for patients with STEMI is unknown. …”
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“…We discuss the implications of these data for how crowd emotion should be conceptualised.…”
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“…Tolerance to crowding stress has played a crucial role in improving agronomic productivity in field corn; however, commercial sweet corn hybrids vary greatly in crowding stress tolerance. …”
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“…In contrast to the already known effect that macromolecular crowding usually promotes biological reactions, solutions of PEG 6k at high concentrations stop the cleavage of DNA by HindIII enzyme, due to the formation of DNA nanoparticles. …”
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“…However, the scientists may have little control over what gets recorded by the crowd, providing a potential source of error and uncertainty. …”
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“…However, cell cytoplasm is highly crowded, which makes particle detection challenging. …”
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“…The identical correlation of cell viability, membrane potential dissipation and morphology with the concentration regime of nisin, in both Bacillus subtilis (lipid II rich) and Escherichia coli (lipid II impoverished), hints at a non-specific physical mechanism where degree of membrane deformation depends on degree of crowding and oligomerization of nisin.…”
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“…In the dense and crowded environment of the cell cytoplasm, an individual protein feels the presence of and interacts with all surrounding proteins. …”
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“…Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in RNA-crowded environments. We competed for Dicer processing of pre-miRNA with a large amount of cellular RNA species and found that Dicer-TRBP, but not Dicer alone, remains resilient. …”
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“…This scoping review aims to assess the utility of social media and crowd-sourced data to detect and monitor adverse events related to health products including pharmaceuticals, medical devices, biologics and natural health products. …”
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“…We determined that molecular crowding conditions and cations, such as Na(+), K(+), Mg(2+) and Ca(2+), promote the formation of G-triplexes and stabilize these structures. …”
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“…Although we perceive a richly detailed visual world, our ability to identify individual objects is severely limited in clutter, particularly in peripheral vision. Models of such “crowding” have generally been driven by the phenomenological misidentifications of crowded targets: using stimuli that do not easily combine to form a unique symbol (e.g. letters or objects), observers typically confuse the source of objects and report either the target or a distractor, but when continuous features are used (e.g. orientated gratings or line positions) observers report a feature somewhere between the target and distractor. …”
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“…We here take a deductive modeling approach to establish the consequences of RNAP–nucleosome interactions for transcription in crowded environments. We show that under physiologically crowded conditions, the interactions of RNAP with nucleosomes induce a strong kinetic attraction between RNAP molecules, causing them to self-organize into stable and moving pelotons. …”
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“…SIMPLE SUMMARY: Waiving adoption fees to encourage adoptions and reduce euthanasias of healthy adult cats in crowded shelters is controversial because of concerns that people attracted to free adoptions may be less responsible owners. …”
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