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  1. 20641
    “…The interface provides an easy and intuitive access for data submission and a user-friendly web interface for annotated variant visualization. Non-IT mastered users can access through WEP to the most updated and tested WES algorithms, tuned to maximize the quality of called variants while minimizing artifacts and false positives. …”
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    WEP: a high-performance analysis pipeline for whole-exome data
  2. 20642
    “…Homologous CDK4 and CDK6 bound to cyclins D are master integrators of mitogenic/oncogenic signaling cascades by initiating the inactivation of the central oncosuppressor pRb and cell cycle commitment at the restriction point. …”
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    CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
  3. 20643
    “…Retinoid X Receptor alpha (RXRα) is an obligate partner for multiple NRs and considered a master regulator of hepatic gene expression, yet the full extent of RXRα chromatin binding in male and female livers is unclear. …”
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    Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice
  4. 20644
    “…BACKGROUND: In 2007, a 3-year online part-time Master of Surgical Sciences (MSc) degree programme was launched, utilizing an innovative platform with virtual case scenarios based on common surgical conditions addressed by the curriculum relating to the Membership Examination of the Royal Colleges of Surgeons (MRCS). …”
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    Distance Learning Improves Attainment of Professional Milestones in the Early Years of Surgical Training
  5. 20645
    “…Submicroscopic parasitaemia samples were subjected to pre-amplification using TaqMan PreAmp Master Mix following the manufacturer’s instructions before SNP barcode analysis. …”
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    Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia
  6. 20646
    “…Healthy adults were recruited from McMaster University between September 2011 and December 2011. …”
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    Online Artículo Texto
    Immunosenescence in the nursing home elderly
  7. 20647
    “…The risk of bias of experimental and quasi-experimental studies will be appraised using the Cochrane Effective Practice and Organization of Care Risk-of-Bias tool, methodological quality of observational studies will be appraised using the Newcastle-Ottawa Scale, and quality of reporting of safety outcomes will be conducted using the McMaster Quality Assessment Scale of Harms (McHarm) tool. …”
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    Comparative safety of anti-epileptic drugs among infants and children exposed in utero or during breastfeeding: protocol for a systematic review and network meta-analysis
  8. 20648
    “…CONCLUSIONS: Various serious complications can occur during locoregional anesthesia techniques in ophthalmic surgery. The mastering and perfecting of these techniques by practitioners and compliance with safety standards in anesthesia are the only way to guarantee the prevention of such complications.…”
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    Convulsions during cataract surgery under peribulbar anesthesia: a case report
  9. 20649
    “…Interestingly, the induction of WIPI-1 expression was dependent on the transcription factor PU.1, a master regulator of myelopoiesis, supporting our notion that WIPI-1 expression is reduced in AML patients lacking proper PU-1 activity. …”
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    WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells
  10. 20650
    “…CONCLUSIONS: This study provides a comprehensive examination of gene activities in bovine embryos and identified little-known potential master regulators of pre-implantation development. …”
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    Transcriptional profiles of bovine in vivo pre-implantation development
  11. 20651
    “…To validate and evaluate the system’s clinical applicability, a simple peg task experiment and workspace identification experiment are performed with five novice volunteers using the fundamentals of laparoscopic surgery (FLS) board kit. The master interface of the proposed system employs the hands-on-throttle-and-stick (HOTAS) controller used in aerospace engineering. …”
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    Pneumatic-type surgical robot end-effector for laparoscopic surgical-operation-by-wire
  12. 20652
    “…The primary outcome measure is pain (Western Ontario and McMaster Universities WOMAC) subscale at 12 weeks. Secondary outcomes include WOMAC stkiffness and function domain scores, lower extremity strength and power, functional balance, physical performance tests, psychological and psychosocial functioning, durability effects, health related quality of life, and healthcare utilization at 12, 24 and 52 weeks. …”
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    Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial
  13. 20653
    “…Knee pain was assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire. …”
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    Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?
  14. 20654
    “…The results provide evidence that soil pH has a marginal direct effect on potential denitrification, but that it is the master variable controlling the percentage of denitrified N emitted as N(2)O. …”
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    Excessive use of nitrogen in Chinese agriculture results in high N(2)O/(N(2)O+N(2)) product ratio of denitrification, primarily due to acidification of the soils
  15. 20655
    “…The following were studied as independent factors: socio-demographic data (age, sex, instruction level, living condition, received help), comorbidities, characteristics of the fracture, treatment performed, destination at discharge, health-related quality of life (12-Item Short Form Health Survey) and hip function (Short Western Ontario and McMaster Universities Osteoarthritis Index). As main outcome functional status was measured (Barthel Index and Lawton Instrumental Activities of Daily Living Scale). …”
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    Factors related to functional prognosis in elderly patients after accidental hip fractures: a prospective cohort study
  16. 20656
    “…The graph yields a stochastic master equation for how microstate probabilities change over time. …”
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    A framework for modelling gene regulation which accommodates non-equilibrium mechanisms
  17. 20657
    “…An adapted version of the Western Ontario and McMaster Universities Osteoarthritis Index was used to assess pain and physical function expectations following total knee arthroplasty before/after the intervention. …”
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    Reducing gender disparities in post-total knee arthroplasty expectations through a decision aid
  18. 20658
    “…Follow-up will be at regular intervals during a 4-week period with a visual analog scale to assess pain, and additional characterization with the Western Ontario and McMaster Universities Index score; rescue medication will be recorded as the extent and time pattern. …”
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    Clinical effectiveness and micro-perfusion alteration of Jingui external lotion in patients with knee osteoarthritis: study protocol for a randomized controlled trial
  19. 20659
    “…The primary assessment tool was the Likert-type Western Ontario and McMaster University (WOMAC) pain scale at weeks 0, 6, 10, 14, 18, and 26. …”
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    Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26-week non-inferiority trial comparing Durolane to Artz
  20. 20660
    “…BACKGROUND: Hox genes are master regulatory genes that specify positional identities during axial development in animals. …”
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    HoxA and HoxD expression in a variety of vertebrate body plan features reveals an ancient origin for the distal Hox program
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