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  1. 1981
    “…Lipid second messengers have essential roles in cellular function and contribute to the molecular mechanisms that underlie inflammation, malignant transformation, invasiveness, neurodegenerative disorders, and infectious and other pathophysiological processes. …”
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    Targeting phospholipase D in cancer, infection and neurodegenerative disorders
  2. 1982
    “…Aim: Osteocalcin and undercarboxylated osteocalcin are suggested to be endocrine messengers from the bones and have been shown to stimulate insulin secretion from pancreatic β-cells. …”
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    Glucose Tolerance Tests and Osteocalcin Responses in Healthy People
  3. 1983
    “…Extracellular miRNAs function as chemical messengers to mediate cell-cell communication. In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. …”
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    Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
  4. 1984
    “…The emerging molecular mechanism is that conditions like hypoxic stress trigger the release of placental messengers into the maternal circulation, which causes preeclampsia. …”
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    The direct and sustained consequences of severe placental hypoxia on vascular contractility
  5. 1985
    “…Members of the target audience are receptive to straightforward facts delivered by authentic messengers about the potentially harmful consequences of SLT use, specifically those that leverage the progression of short-term consequences (e.g., white patches) to long-term health effects. …”
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    Developing Smokeless Tobacco Prevention Messaging for At-Risk Youth: Early Lessons from “The Real Cost” Smokeless Campaign
  6. 1986
    “…Bile acids are critical biological detergents in the gastrointestinal tract and also act as messengers to regulate a multitude of intracellular signaling events, including mitogenic signaling, lipid metabolism and endo/exocytosis. …”
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    Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling
  7. 1987
    “…Enzymes controlling intracellular second messengers in bacteria, such as c-di-GMP, often affect some but not other targets. …”
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    Signaling specificity in the c-di-GMP-dependent network regulating antibiotic synthesis in Lysobacter
  8. 1988
    “…Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive TRP (thermoTRPV) channels, is activated by warm temperatures and serves as a key regulator of normal skin physiology through the release of pro-inflammatory messengers. Mutations in trpv3 have been identified as the cause of the congenital skin disorder, Olmsted syndrome. …”
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    Conformational ensemble of the human TRPV3 ion channel
  9. 1989
    por Lang, Di, Glukhov, Alexey V.
    Publicado 2018
    “…These protein–protein interactions are tightly controlled and regulated by a variety of neurohormonal signaling pathways and the diversity of cellular responses achieved with a limited pool of second messengers is made possible through the organization of essential signal components in particular microdomains. …”
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    Functional Microdomains in Heart’s Pacemaker: A Step Beyond Classical Electrophysiology and Remodeling
  10. 1990
    por Han, Liu, Lam, Eric W.-F., Sun, Yu
    Publicado 2019
    “…EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. …”
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    Extracellular vesicles in the tumor microenvironment: old stories, but new tales
  11. 1991
    “…They can be modulated either by calcium itself and/or by calcium-binding proteins (CBPs). Intracellular messengers usually interact with binding domains present at the most variable TRP regions—N- and C-cytoplasmic termini. …”
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    TRPM6 N-Terminal CaM- and S100A1-Binding Domains
  12. 1992
    “…These distortions minimize the true extent to which SPR is stabilized by locality in cGMP depletion, nonlinear effects linking cGMP to current, and Ca(2+) feedback arising from the physical separation of E* from the ion channels located on the outer shell, and the diffusion of these second messengers in the cytoplasm.…”
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    Local, nonlinear effects of cGMP and Ca(2+) reduce single photon response variability in retinal rods
  13. 1993
    “…One of the best known roles for NOXs is in host protection against pathogens but ROS themselves are important second messengers involved in tissue regeneration and the modulation of pathways that induce and sustain cell proliferation. …”
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    A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action
  14. 1994
    “…Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle and are required to react rapidly to environmental stimuli. …”
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    Studying signal compartmentation in adult cardiomyocytes
  15. 1995
    por Luo, Jing, Liu, Dongmin
    Publicado 2020
    “…Unlike the genomic responses, where the classical nuclear ERα and ERβ act as transcriptional factors following estrogen binding to regulate gene transcription in estrogen target tissues, the non-genomic cellular responses to estrogen are believed to start at the plasma membrane, leading to rapid activation of second messengers-triggered cytoplasmic signal transduction cascades. …”
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    Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?
  16. 1996
    “…Cyclic dinucleotides (CDNs) are second messengers conserved across all three domains of life. …”
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    A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
  17. 1997
    “…Additionally, ROS originating from both NOX and the mitochondria may act as second messengers to propagate immune activation; thus intracellular ROS signalling may underlie excessive inflammation and OS. …”
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    ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
  18. 1998
    “…However, we lack mechanistic insight into how TRPA1 recognizes and responds to electrophiles or cytoplasmic second messengers. Here, we show that electrophiles act through a two-step process in which modification of a highly reactive cysteine (C621) promotes reorientation of a cytoplasmic loop to enhance nucleophilicity and modification of a nearby cysteine (C665), thereby stabilizing the loop in an activating configuration. …”
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    Irritant-evoked activation and calcium modulation of the TRPA1 receptor
  19. 1999
    “…Second messenger signaling controls a surprisingly diverse range of processes in several eukaryotic pathogens. …”
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    Uncovering the Cyclic AMP Signaling Pathway of the Protozoan Parasite Entamoeba histolytica and Understanding Its Role in Phagocytosis
  20. 2000
    “…MicroRNAs are thought to act as tumor messengers to “corrupt” stromal cells. We previously demonstrated that miR-9, a known metastamiR, is released by triple negative breast cancer (TNBC) cells to enhance the transition of normal fibroblasts (NFs) into cancer-associated fibroblast (CAF)-like cells. …”
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    miR-9-Mediated Inhibition of EFEMP1 Contributes to the Acquisition of Pro-Tumoral Properties in Normal Fibroblasts
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