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  1. 2241
    “…Cancer induces immune suppression to overcome its recognition and eradication by the immune system. Cytokines are messengers able to modulate immune response or suppression. …”
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    Circulating Cytokines in Metastatic Breast Cancer Patients Select Different Prognostic Groups and Patients Who Might Benefit from Treatment beyond Progression
  2. 2242
    “…The stringent response enables bacteria to respond to nutrient limitation and other stress conditions through production of the nucleotide-based second messengers ppGpp and pppGpp, collectively known as (p)ppGpp. …”
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    Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp
  3. 2243
    “…Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. …”
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    cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors
  4. 2244
    “…To evaluate this so-called biased agonism for H(1)R, bioluminescence resonance energy transfer (BRET)-based biosensors were applied to measure H(1)R signaling through heterotrimeric G(q) proteins, second messengers (inositol 1,4,5-triphosphate and Ca(2+)), and receptor-protein interactions (GRKs and β-arrestins) in response to histamine, 2-phenylhistamines, and histaprodifens in a similar cellular background. …”
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    BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H(1) Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins
  5. 2245
    “…Several mechanisms of chemoresistance have been identified, including drug transporters, key secondary messengers, and metabolic regulators. However, no therapeutic approach targeting chemoresistance has succeeded in clinical trials, especially due to broad secondary effects in healthy cells. …”
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    Lysosome-mediated chemoresistance in acute myeloid leukemia
  6. 2246
    “…Extracellular vesicles (EVs) are lipid bilayer-delimited nanoparticles and key messengers in cell-to-cell communication. Many publications indicate that microbial EVs are both positively and negatively involved in the pathogenesis of various intractable diseases, including inflammatory diseases, metabolic disorders, and cancers. …”
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    A new horizon of precision medicine: combination of the microbiome and extracellular vesicles
  7. 2247
    “…The pharmacological efficacies of carbon monoxide (CO) and xenon (Xe) are further examined with emphasis on intracellular messengers associated with cytoprotection and functional improvement for the CNS, heart, retina, liver, kidneys, lungs, etc. …”
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    Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges
  8. 2248
    “…We therefore undertook an in-depth cellular and molecular comparative study of CXCR3-A and CXCR3-B, investigating their activation at different levels of the signaling cascades, including G protein coupling, β-arrestin recruitment and modulation of secondary messengers as well as their downstream gene response elements. …”
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    The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B
  9. 2249
    “…Members of the Penn State CTSI were invited to serve on state and local advisory bords and became trusted messengers in our communities.…”
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    164 Better Together: Community Engagement During COVID-19
  10. 2250
    “…Additionally, this direct approach for EV analysis will enable researchers to explore corners of EVs as cellular messengers in healthy and pathological conditions.…”
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    An imaging flow cytometry-based methodology for the analysis of single extracellular vesicles in unprocessed human plasma
  11. 2251
    “…The program is delivered by community resident “credible messengers,” who conduct the mentorship and interrupt conflicts in the streets. …”
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    Preventing Urban Firearm Homicides during COVID-19: Preliminary Results from Three Cities with the Advance Peace Program
  12. 2252
    “…Trained diabetes advocates could be core messengers. However, interdisciplinary cooperation is mandatory for both education and the clinical aspect of diabetes care. …”
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    Oral Health Knowledge and Habits of People With Type 1 and Type 2 Diabetes
  13. 2253
    “…Extracellular vesicles (EVs), defined as intercellular messengers that carry their cargos between cells, are involved in several physiological and pathological processes. …”
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    Role of exosomal microRNAs in cancer therapy and drug resistance mechanisms: focus on hepatocellular carcinoma
  14. 2254
    “…SOS1 function in circadian clock regulation requires the salt-mediated secondary messengers cytosolic free calcium and reactive oxygen species, pointing to a distinct regulatory role for SOS1 in addition to its function as a transporter to maintain Na(+) homeostasis. …”
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    The Na(+)/H(+) antiporter SALT OVERLY SENSITIVE 1 regulates salt compensation of circadian rhythms by stabilizing GIGANTEA in Arabidopsis
  15. 2255
    “…Reactive oxygen species (ROS) act as secondary messengers that can be sensed by specific redox-sensitive proteins responsible for the activation of signal transduction culminating in altered gene expression. …”
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    Gene network downstream plant stress response modulated by peroxisomal H(2)O(2)
  16. 2256
    “…Here, we present event-triggered STED, an automated multiscale method capable of rapidly initiating two-dimensional (2D) and 3D STED imaging after detecting cellular events such as protein recruitment, vesicle trafficking and second messengers activity using biosensors. STED is applied in the vicinity of detected events to maximize the temporal resolution. …”
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    Event-triggered STED imaging
  17. 2257
    “…Mitochondrial reactive oxygen species (mtROS) are cellular messengers essential for cellular homeostasis. In response to stress, reverse electron transport (RET) through respiratory complex I generates high levels of mtROS. …”
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    Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
  18. 2258
    “…Phosphoinositides are important second messengers that regulate key cellular processes in eukaryotes. …”
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    A VPS15-like kinase regulates apicoplast biogenesis and autophagy by promoting PI3P generation in Toxoplasma gondii
  19. 2259
    por Williamson, Lillie D., Tarfa, Adati
    Publicado 2022
    “…The findings have implications for future communication efforts from healthcare professionals and health messengers.…”
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    Examining the relationships between trust in providers and information, mistrust, and COVID-19 vaccine concerns, necessity, and intentions
  20. 2260
    “…Reactive oxygen species (ROS) as second messengers and oxidative modifications of cysteinyl (Cys) residues are key to transduce and translate intracellular and intercellular signals. …”
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    Redox signaling and metabolism in Alzheimer's disease
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