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  1. 2261
    “…At a molecular level, vinpocetine and celecoxib treatments modulated the downstream messengers of GPR91 (i.e., ERK1/2 and JNK), suppressed NF-κB and IL-1β expressions in the bladder, and prevented the fibrogenesis observed in FFRs. …”
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    Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle
  2. 2262
    “…CBLs are ubiquitous Ca(2+) sensors that interact with CIPK with the aid of secondary Ca(2+) messengers for regulation of growth and development and response to stresses faced by plants. …”
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    Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study
  3. 2263
    por Shearn, Christina, Krockow, Eva M.
    Publicado 2023
    “…Thematic synthesis identified three main themes of “institutional mistrust”, “lack of confidence in vaccine and vaccine development process”, and “lack of reliable information or messengers”. Two minor themes included “complacency/perceived lack of need” and “structural barriers to vaccine access”. …”
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    Reasons for COVID-19 vaccine hesitancy in ethnic minority groups: A systematic review and thematic synthesis of initial attitudes in qualitative research
  4. 2264
    “…These cells respond to external and internal signals, producing a wide array of primary or secondary messengers involved in coagulation, vascular tone, inflammation, and cell-to-cell signaling. …”
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    Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review
  5. 2265
    por Tortonese, Domingo J.
    Publicado 2022
    “…The resulting melatonin‐evoked differential productions of VEGF‐A isoforms will induce seasonal remodeling of the vascular connection between the hypothalamus and hypophysis, and act as paracrine messengers in the pars distalis to generate the required seasonal endocrine response. …”
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    Hypophysial angiogenesis decodes annual time and underlies physiological adaptation to seasonal changes in the environment
  6. 2266
    “…The endocannabinoid system (ECS) is comprised of a set of lipid-derived messengers (the endocannabinoids, ECBs), proteins that control their production and degradation, and cell-surface cannabinoid (CB) receptors that transduce their actions. …”
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    Phytocannabinoids, the Endocannabinoid System and Male Reproduction
  7. 2267
    “…Exosomes, as cell-to-cell communication messengers, can reflect the functional changes of their source cell. …”
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    Biomarkers and Tools for Predicting Alzheimer’s Disease in the Preclinical Stage
  8. 2268
    por Kaur, Jasmeet, Dora, Sanchit
    Publicado 2023
    “…Purines are building blocks of nucleic acids but also function as metabolic intermediates and messengers, as part of a signaling pathway known as purinergic signaling. …”
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    Purinergic signaling: Diverse effects and therapeutic potential in cancer
  9. 2269
    “…The binding of extracellular ligands to GPCRs activates a heterotrimeric G protein and triggers the production of numerous secondary messengers, which transduce the extracellular signals into cellular responses. …”
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    An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis
  10. 2270
    por Amaro-Seoane, Pau, Audley, Heather, Babak, Stanislav, Baker, John, Barausse, Enrico, Bender, Peter, Berti, Emanuele, Binetruy, Pierre, Born, Michael, Bortoluzzi, Daniele, Camp, Jordan, Caprini, Chiara, Cardoso, Vitor, Colpi, Monica, Conklin, John, Cornish, Neil, Cutler, Curt, Danzmann, Karsten, Dolesi, Rita, Ferraioli, Luigi, Ferroni, Valerio, Fitzsimons, Ewan, Gair, Jonathan, Gesa, Lluis, Giardini, Domenico, Gibert, Ferran, Grimani, Catia, Halloin, Hubert, Heinzel, Gerhard, Hertog, Thomas, Hewitson, Martin, Holley-Bockelmann, Kelly, Hollington, Daniel, Hueller, Mauro, Inchauspe, Henri, Jetzer, Philippe, Karnesis, Nikos, Killow, Christian, Klein, Antoine, Klipstein, Bill, Korsakova, Natalia, Larson, Shane L., Livas, Jeffrey, Lloro, Ivan, Man, Nary, Mance, Davor, Martino, Joseph, McKenzie, Kirk, McWilliams, Sean T., Miller, Cole, Mueller, Guido, Nardini, Germano, Nelemans, Gijs, Nofrarias, Miquel, Petiteau, Antoine, Pivato, Paolo, Plagnol, Eric, Porter, E., Reiche, Jens, Robertson, David, Robertson, Norna, Rossi, Elena, Russano, Giuliana, Schutz, Bernard, Sesana, Alberto, Shoemaker, David, Slutsky, Jacob, Sopuerta, Carlos F., Sumner, Tim, Tamanini, Nicola, Thorpe, Ira, Troebs, Michael, Vallisneri, Michele, Vecchio, Alberto, Vetrugno, Daniele, Vitale, Stefano, Wanner, Gudrun, Ward, Harry, Wass, Peter, Weber, William, Ziemer, John, Zweifel, Peter
    Publicado 2017
    “…LISA is an all-sky monitor and will offer a wide view of a dynamic cosmos using Gravitational Waves as new and unique messengers to unveil The Gravitational Universe. It provides the closest ever view of the infant Universe at TeV energy scales, has known sources in the form of verification binaries in the Milky Way, and can probe the entire Universe, from its smallest scales near the horizons of black holes, all the way to cosmological scales. …”
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    Laser Interferometer Space Antenna
  11. 2271
    “…Free radicals are known to communicate the intracellular and extracellular compartments, acting as second messengers and exerting a decisive modulatory effect on tumour cell signalling. …”
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    Involvement of redox signalling in tumour cell dormancy and metastasis
  12. 2272
    “…The gene set enrichment analysis confirmed that the genes involved in signal transduction, such as growth factor receptors and second messengers, EGFR tyrosine kinase inhibitors, and PI3K signaling pathways, were mostly related with TSCCs. …”
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    Assessment of the Mutation Profile of Tonsillar Squamous Cell Carcinomas Using Targeted Next-Generation Sequencing
  13. 2273
    “…SIMPLE SUMMARY: Extracellular vesicles are considered intracellular messengers that exchange proteins, lipids, various types of DNA and RNA, etc. …”
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    Extracellular Vesicles as Biomarkers in Head and Neck Squamous Cell Carcinoma: From Diagnosis to Disease-Free Survival
  14. 2274
    “…Bacteria produce a variety of nucleotide second messengers to adapt to their surroundings. Although chemically similar, the nucleotides guanosine penta- and tetraphosphate [(p)ppGpp] and adenosine penta- and tetraphosphate [(p)ppApp] have distinct functions in bacteria. …”
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    Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp
  15. 2275
    “…Interventions to promote vaccination should include trusted messengers and sources of information, while long term efforts should focus on addressing the social conditions that deter confidence in scientific data, vaccine efficacy, and the healthcare system.…”
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    Disparities in COVID-19 vaccine hesitancy among a diverse community-based sample in Connecticut, United States
  16. 2276
    por Junkermeier, Eike H, Hengge, Regine
    Publicado 2023
    “…For many years the surprising multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins has intrigued researchers studying bacterial second messengers. How can several signaling pathways act in parallel to produce specific outputs despite relying on the same diffusible second messenger maintained at a certain global cellular concentration? …”
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    Local signaling enhances output specificity of bacterial c-di-GMP signaling networks
  17. 2277
    “…SIMPLE SUMMARY: Extracellular vesicles (EVs), consisting of microvesicles and exosomes, serve as messengers for intercellular communication by transporting proteins and nucleic acids. …”
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    Extracellular Vesicles and Epidermal Growth Factor Receptor Activation: Interplay of Drivers in Cancer Progression
  18. 2278
    “…Main features of endocannabinoids (eCBs) are that they are produced on demand, in response to enhanced neuronal activity, act as retrograde messengers, and participate in the induction of brain plasticity processes. …”
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    The endogenous cannabinoid system modulates male sexual behavior expression
  19. 2279
    “…Although many studies have demonstrated that reactive oxygen species (ROS) serve as important signaling messengers to modify the cell wall structure and affect cellular growth, the regulatory mechanism underlying the spatial-temporal regulation of ROS activity for cell wall maintenance remains largely unclear. …”
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    Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots
  20. 2280
    “…Programs utilizing trusted-messenger systems were deemed most effective, but resource-intensive. …”
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    What Chicago community organizations needed to implement COVID-19 interventions: lessons learned in 2021
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