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  1. 2281
    “…Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive. …”
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    Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases
  2. 2282
    “…Small extracellular vesicles (sEVs) serve as emerging messengers to connect primary tumour and metabolic organs to exert systemic regulation. …”
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    Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
  3. 2283
    “…Augmenting platelet factors, possible messengers of klotho, may enhance cognition in the young brain and decrease cognitive deficits in the aging brain.…”
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    Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
  4. 2284
    “…These signaling molecules act as messengers in the tumor microenvironment, especially the tumor immunosuppressive microenvironment. …”
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    An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment
  5. 2285
    “…Once activated, their levels of ROS increase, as messengers to mediate their proliferation and differentiation programs. …”
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    The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-Mediated Loss of Functions
  6. 2286
    “…The moderate production of reactive oxidative species (ROS) is important because ROS act as second messengers. However, their depletion through the over-activity of the antioxidant system may lead to reductive stress (RS) which is characterized by an increase in reducing equivalents and an elevation of some components of the antioxidant system disturbing redox homeostasis. …”
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    Alteration of the aortic vascular reactivity associated to excessive consumption of Hibiscus sabdariffa Linnaeus: Preliminary findings
  7. 2287
    “…The questionnaires were sent to participants through online messengers. The obtained data were analyzed by SPSS software (v25). …”
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    The Sexual Function, Desire, and Satisfaction of Couples during the Outbreak of COVID-19 in Qazvin
  8. 2288
    “…Results of our in-depth bioinformatics evaluations, highlighted pathways related to regulation of immune responses, T-cell receptor and activation, regulation of cell signaling receptors and messengers, Wnt signaling pathway, and apoptosis as key players in ATLL pathogenesis. …”
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    Illuminating (HTLV-1)-induced adult T-cell leukemia/lymphoma transcriptomic signature: A systems virology approach
  9. 2289
    “…These two gene products complement the activity of previously described members of the DIPP family, and reinforce the concept that Ap(5)A and Ap(6)A act as intracellular messengers.…”
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    Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
  10. 2290
    “…Our results show that PtdIns(4,5)P(2) is a key regulator of Cx43 channel function, with no role for other second messengers, and suggest that ZO-1 assembles PLCβ3 and Cx43 into a signaling complex to allow regulation of cell–cell communication by localized changes in PtdIns(4,5)P(2).…”
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    Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate
  11. 2291
    Publicado 1985
    “…The subcellular localization of the Ca2+/calmodulin-dependent protein kinase appears to be under control of two second messengers: Ca2+ and cAMP. We find that the Mr 55,000 subunit is phosphorylated when the extracted membrane- cytoskeleton complex is incubated with Ca2+, calmodulin, and ATP, with the concomitant release of this phosphorylated peptide from the complex. …”
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    Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons
  12. 2292
    Publicado 1985
    “…A possible role of several putative intracellular second messengers in NE receptor-Ca channel coupling was investigated. …”
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    Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons
  13. 2293
    “…This increase in BK(Ca) channel activity is not due to Ca(2+)-dependent mechanism(s) or changes in freely diffusible messengers, but to a direct action of the bile acid on the channel protein itself or some closely associated component in the cell membrane. …”
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    Natural Bile Acids and Synthetic Analogues Modulate Large Conductance Ca(2+)-activated K(+) (BK(Ca)) Channel Activity in Smooth Muscle Cells
  14. 2294
    por Lipton, SA, Rasmussen, H, Dowling, JE
    Publicado 1977
    “…These findings suggest that Ca(2+) and cGMP are interrelated messengers. We speculate that low Ca(2+) may lead to increased intracellular cGMP, and/or that applied cGMP, and/or that applied cGMP may lower cytosol Ca(2+), perhaps by stimulating Ca(2+)- ATPase pumps in the outer segment.…”
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    Electrical and adaptive properties of rod photoreceptors in bufo marinus. II. Effects of cyclic nucleotides and protaglandins
  15. 2295
    por Yang, Yan, Gillis, Kevin D.
    Publicado 2004
    “…We conclude that glucose and second messengers can modulate insulin release triggered by a high-affinity Ca(2+) sensor that is poised to respond to modest, global elevations of [Ca(2+)](i).…”
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    A Highly Ca(2+)-sensitive Pool of Granules Is Regulated by Glucose and Protein Kinases in Insulin-secreting INS-1 Cells
  16. 2296
    “…Dimorphism in S. schenckii responds to second messengers such as cAMP and calcium, suggesting the possible involvement of a calcium/calmodulin kinase in its regulation. …”
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    Functional, genetic and bioinformatic characterization of a calcium/calmodulin kinase gene in Sporothrix schenckii
  17. 2297
    por Turner, P L, Mainster, M A
    Publicado 2008
    “…This information permits human physiology to be optimised and aligned with geophysical day–night cycles using neural and hormonal messengers including melatonin. Age-related transmittance spectra of crystalline lenses and photopic pupil diameter are used with the spectral sensitivity of melatonin suppression and the transmittance spectra of intraocular lenses (IOLs) to analyse how ageing and IOL chromophores affect circadian photoreception. …”
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    Circadian photoreception: ageing and the eye’s important role in systemic health
  18. 2298
    “…This study provides clear evidence for galanin and galanin receptor expression in human neuroblastic tumours. The messengers coding for galanin, Gal-R1 and -R3 were highly expressed in neuroblastoma and their amount dramatically decreased in ganglioneuroma. …”
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    Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status
  19. 2299
    “…Ras functions as a ‘molecular switch’ in transduction of signals from the membrane receptors of many growth factors, cytokines, and other second messengers to the cell nucleus. Numerous studies have shown that in multiple malignant tumors and hematopoietic malignancies, faulty signal transduction via the Ras pathway plays a key role in tumorigenesis. …”
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    Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation
  20. 2300
    “…Characterization of the first tomato strigolactone-deficient mutant supports the putative general role of strigolactones as messengers of suppression of lateral shoot branching in a diversity of plant species.…”
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    A tomato strigolactone-impaired mutant displays aberrant shoot morphology and plant interactions
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