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  1. 2381
    “…BACKGROUND: Tumor-derived exosomes are messengers that participate in tumor progression. Fibroblasts are associated with the metastasis of cancer depending on their cellular plasticity. …”
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    Melanoma-Derived Exosomes Endow Fibroblasts with an Invasive Potential via miR-21 Target Signaling Pathway
  2. 2382
    “…In tandem with local signaling, tumors transmit protein and RNA messengers within extracellular vesicles that travel through the bloodstream and other bodily fluids. …”
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    Interrupting Neuron—Tumor Interactions to Overcome Treatment Resistance
  3. 2383
    “…In recent times, it is widely accepted that these toxic by-products could act as secondary messengers, such as hydrogen peroxide (H(2)O(2)), to drive important signaling pathways. …”
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    The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide
  4. 2384
    “…In the context of tumor interactions, extracellular vesicles are essential in number of key aspects in oncology: as major interactors with extracellular matrix, as cell-to-cell messengers, as carriers of diagnostic-valuable biomarkers, and as target-specific treatment-deliver agents. …”
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    3D Cell Cultures as Prospective Models to Study Extracellular Vesicles in Cancer
  5. 2385
    “…In order to adjust to changing environmental conditions, bacteria use nucleotide second messengers to transduce external signals and translate them into a specific cellular response. …”
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    Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis
  6. 2386
    “…The membrane lipids diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers that can regulate membrane transport by recruiting proteins to the membrane and by altering biophysical membrane properties. …”
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    Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
  7. 2387
    “…Cyclic di-nucleotides (CDN) are bacterial second messengers that are rapidly sensed by the immune system as a danger signal, allowing the utilization of these molecules as potent activators of the immune response. …”
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    Cyclic Di-Adenosine Monophosphate: A Promising Adjuvant Candidate for the Development of Neonatal Vaccines
  8. 2388
    “…However, the cross-talk messengers between respiratory mucosal immunity and gut microbiota are largely unknown. …”
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    Gentamicin Induced Microbiome Adaptations Associate With Increased BCAA Levels and Enhance Severity of Influenza Infection
  9. 2389
    “…Indeed, EVs isolated from tumor and stromal cells act as key messengers in intercellular communications able to propagate traits of resistance and/or educate the microenvironment to sustain a breast cancer resistant phenotype. …”
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    The Emerging Role of Extracellular Vesicles in Endocrine Resistant Breast Cancer
  10. 2390
    “…Biological functions of Calculus Bovis are associated with protein hydrolyzation, phosphorylation of serine/threonine residues of protein substrates, peptide bond hydrolyzation of peptides and proteins, hydrolyzation of intracellular second messengers, antioxidation and reduction, RNA transcription, and other biological processes. …”
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    A Network Pharmacology to Explore the Mechanism of Calculus Bovis in the Treatment of Ischemic Stroke
  11. 2391
    “…Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. …”
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    From purines to purinergic signalling: molecular functions and human diseases
  12. 2392
    “…BACKGROUND: Extracellular vesicles (EVs) are intercellular messengers with epigenetic potential since they can shuttle microRNA (miRNA). …”
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    Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIV
  13. 2393
    “…Extracellular vesicles (EV) function as messengers between endothelial cells (EC) and vascular smooth muscle cells (VSMC). …”
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    Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT‐1 expression
  14. 2394
    “…The results showed that this Palaearctic night migrant possesses a magnetic compass, as well as the fact that magnetic cues act as primary directional messengers. When birds were exposed to different environmental conditions at 22 °C and 38 °C temperatures under simulated overcast conditions, they showed a delay in Zugunruhe (migratory restlessness) at 22 °C, while an advance migratory restlessness was observed under 38 °C conditions. …”
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    Magnetic Compass Orientation in a Palaearctic–Indian Night Migrant, the Red-Headed Bunting
  15. 2395
    “…ROS may modulate cancer cell metabolism by acting as secondary messengers in the signaling pathways (NF-kB, HIF-1α) involved in cellular proliferation and metastasis. …”
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    Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation
  16. 2396
    “…However, many of these studies are based on measurements of second messengers or gene transcription that occurs many steps downstream of receptor activation and can represent convergence points of several signalling pathways. …”
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    Heterogeneity of G protein activation by the calcium-sensing receptor
  17. 2397
    “…Exosomes serve as intercellular messengers and carry molecular cargo that can alter gene expression and the phenotype of recipient cells. …”
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    Exosomes in Epilepsy of Tuberous Sclerosis Complex: Carriers of Pro-Inflammatory MicroRNAs
  18. 2398
    “…Age and race differences in perspectives highlight the need for tailored education, delivered by trusted messengers.…”
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    COVID-19 vaccine perceptions in New York State's intellectual and developmental disabilities community
  19. 2399
    “…Our results show that two ancient second messengers are independently generated in nanodomains close to Orai1 Ca(2+) channels.…”
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    AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca(2+) Channels
  20. 2400
    “…Volatiles are important airborne chemical messengers that facilitate plant adaptation to a variety of environmental challenges. …”
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    The Synthesis of Pentyl Leaf Volatiles and Their Role in Resistance to Anthracnose Leaf Blight
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