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10481por Gaupels, Frank, Furch, Alexandra C. U., Zimmermann, Matthias R., Chen, Faxing, Kaever, Volkhard, Buhtz, Anja, Kehr, Julia, Sarioglu, Hakan, Kogel, Karl-Heinz, Durner, Jörg“…We also found that leaf injury triggered the systemic accumulation of cyclic guanosine monophosphate (cGMP) in the EFP and discuss the possible function of this second messenger in systemic NO and redox signaling within the EFP.…”
Publicado 2016
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10482“…Western blotting was used to investigate the effects of caffeine pretreatment on the ATM-Chk2-p53-Puma axis, while real-time polymerase chain reaction (RT-PCR) assessed changes in messenger RNA levels of p53 and downstream targets responding to IR. …”
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10483por Hernangómez, Miriam, Klusáková, Ilona, Joukal, Marek, Hradilová-Svíženská, Ivana, Guaza, Carmen, Dubový, Petr“…Simultaneously, CD200Fc attenuated activation of glial cells and decreased proinflammatory and increased anti-inflammatory cytokine messenger RNA (mRNA) levels. Administration of CD200Fc also diminished elevation of CD200 and CD200R proteins as a concomitant reaction of the modulatory system to increased neuroinflammatory reactions after nerve injury. …”
Publicado 2016
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10484por Broek, Jantine A. C., Lin, Zhanmin, de Gruiter, H. Martijn, van ‘t Spijker, Heleen, Haasdijk, Elize D., Cox, David, Ozcan, Sureyya, van Cappellen, Gert W. A., Houtsmuller, Adriaan B., Willemsen, Rob, de Zeeuw, Chris I., Bahn, Sabine“…This leads to a lack of fragile X mental retardation protein (FMRP), which regulates translation of a wide range of messenger RNAs (mRNAs). The extent of expression level alterations of synaptic proteins affected by FMRP loss and their consequences on synaptic dynamics in FXS has not been fully investigated. …”
Publicado 2016
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10485por Berman, Joan W., Carvallo, Loreto, Buckner, Clarisa M., Luers, Aimée, Prevedel, Lisa, Bennett, Michael V., Eugenin, Eliseo A.“…Cx43 upregulation is mediated by binding of the HIV-tat protein to the Cx43 promoter, but not to the Cx30 promoter, resulting in increased Cx43 messenger RNA (mRNA) and protein as well as gap junctional communication. …”
Publicado 2016
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10486por Ostaff, M J, Schäfer, C, Courth, L, Stebe, S R D, Ott, G, Stange, E F, Wehkamp, J“…METHODS: In 22 patients with heavy alcohol use and 17 control subjects, biopsies from gastric corpus, antrum, and duodenum were examined for messenger RNA (mRNA) of AMPs, cytokines, and Wnt pathway factors using real-time PCR. …”
Publicado 2015
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10487por Meira, Maria, Sievers, Claudia, Hoffmann, Francine, Haghikia, Aiden, Rasenack, Maria, Décard, Bernhard F., Kuhle, Jens, Derfuss, Tobias, Kappos, Ludwig, Lindberg, Raija L.P.“…OBJECTIVES: To assess messenger RNA (mRNA) expression of POU2AF1 and Spi-B and their potential regulatory microRNAs (miRNAs) in natalizumab-treated patients with multiple sclerosis and in therapy-associated progressive multifocal leukoencephalopathy (PML). …”
Publicado 2016
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10488“…Due to the existence of several protein (and messenger RNA (mRNA)) isoforms, these mutations were stratified, using the protein sequence which is considered canonical. …”
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10489por Corcoran, K A, Leaderbrand, K, Jovasevic, V, Guedea, A L, Kassam, F, Radulovic, J“…These effects were unrelated to the MK-801-induced changes of brain-derived neurotrophic factor messenger RNA levels. Together, the findings suggest that NR2B–RACK1 complexes specifically contribute to fear extinction, and may provide a target for the treatment of PTSD. …”
Publicado 2015
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10490Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissuepor Szrok, Sylwia, Stelmanska, Ewa, Turyn, Jacek, Bielicka-Gieldon, Aleksandra, Sledzinski, Tomasz, Swierczynski, Julian“…Altered expressions of MT1 and MT2 genes in all main fat depots were reflected by changes in serum MT1 and MT2 levels. MT1 and MT2 messenger RNA (mRNA) levels in WAT correlated inversely with serum insulin concentration. …”
Publicado 2016
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10491por Zou, Tiande, Yu, Bing, Yu, Jie, Mao, Xiangbing, Zheng, Ping, He, Jun, Huang, Zhiqing, Liu, Yue, Chen, Daiwen“…Maternal LE diet decreased the messenger RNA (mRNA) expression of genes involved in mitochondrial biogenesis and function such as peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A), nuclear respiratory factor 1 (NRF1), mitochondrial transcription factor A (TFAM), β subunit of mitochondrial H(+)-ATP synthase (ATB5B), sirtuin 1 (Sirt1), and citrate synthase (CS). …”
Publicado 2016
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10492por Alkabie, Samir, Basivireddy, Jayasree, Zhou, Lixin, Roskams, Jane, Rieckmann, Peter, Quandt, Jacqueline A.“…SPARC protein levels were quantified by Western blotting and immunocytochemistry and messenger RNA (mRNA) by RT-PCR. RESULTS: Constitutive SPARC expression by proliferating hCMEC/D3s is reduced as cells mature and establish a confluent monolayer. …”
Publicado 2016
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10493por Wei, Junfei, Damania, Ashish, Gao, Xin, Liu, Zhuyun, Mejia, Rojelio, Mitreva, Makedonka, Strych, Ulrich, Bottazzi, Maria Elena, Hotez, Peter J., Zhan, Bin“…METHODS: In order to discover additional hookworm vaccine antigens, messenger RNA was obtained from the intestine of male hookworms, Ancylostoma ceylanicum, maintained in hamsters. …”
Publicado 2016
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10494“…Here, we show that the behavioral deficits and the increased 5MC and 5HMC at glutamic acid decarboxylase 67 (Gad1), reelin (Reln) and brain-derived neurotrophic factor (Bdnf) promoters and the reduced expression of the messenger RNAs (mRNAs) and proteins corresponding to these genes in FC of adult PRS mice is reversed by treatment with clozapine (5 mg kg(−1) twice a day for 5 days) but not by haloperidol (1 mg kg(−1) twice a day for 5 days). …”
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10495por Reddy, I A, Pino, J A, Weikop, P, Osses, N, Sørensen, G, Bering, T, Valle, C, Bluett, R J, Erreger, K, Wortwein, G, Reyes, J G, Graham, D, Stanwood, G D, Hackett, T A, Patel, S, Fink-Jensen, A, Torres, G E, Galli, A“…Interestingly, acute administration of Ex-4 reduces septal expression of the retrograde messenger 2-arachidonylglycerol (2-AG), as well as a product of its presynaptic degradation, arachidonic acid (AA). …”
Publicado 2016
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10496por Sathishkumar, Chandrakumar, Prabu, Paramasivam, Balakumar, Mahalingam, Lenin, Raji, Prabhu, Durai, Anjana, Ranjith Mohan, Mohan, Viswanathan, Balasubramanyam, Muthuswamy“…While subtypes of HDACs were differentially expressed at their transcriptional levels in patients with type 2 diabetes, the most prominent observation is the significantly (p < 0.05) elevated messenger RNA (mRNA) levels of HDAC3. Expression levels of Sirt1 which represents the class III HDAC were decreased significantly in T2DM (p < 0.05). …”
Publicado 2016
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10497“…BACKGROUND: Ca(2+) ion is a versatile second messenger that operate in a wide ranges of cellular processes that impact nearly every aspect of life. …”
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10498por Sade, Y, Toker, L, Kara, N Z, Einat, H, Rapoport, S, Moechars, D, Berry, G T, Bersudsky, Y, Agam, G“…Namely, IP(3) but not IP(1) reduced the immobility time of wild-type mice in the forced swim test model of antidepressant action by 30%, an effect that was reversed by an antagonist of all three IP(3) receptors; amphetamine-induced hyperlocomotion of wild-type mice (distance traveled) was 35% reduced by IP(3) administration; IP(3) administration increased hippocampal messenger RNA levels of Beclin-1 (required for autophagy execution) and hippocampal and frontal cortex protein levels ratio of Beclin-1/p62 by about threefold (p62 is degraded by autophagy). …”
Publicado 2016
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10499por Zhu, Huanxi, Chen, Zhe, Shao, Xibin, Yu, Jianning, Wei, Chuankun, Dai, Zichun, Shi, Zhendan“…The stimulation of reproductive activities caused by the increasing photoperiod was associated with increases in gonadotropin-releasing hormone (GnRH), but decreases in gonadotropin-inhibitory hormone (GnIH) and vasoactive intestinal peptide (VIP) gene messenger RNA (mRNA) levels in the hypothalamus. In the pituitary gland, the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) mRNA abruptly increased during the longer 12-hour photoperiod. …”
Publicado 2017
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10500por Rudra, Pratyaydipta, Shi, W. Jenny, Vestal, Brian, Russell, Pamela H., Odell, Aaron, Dowell, Robin D., Radcliffe, Richard A., Saba, Laura M., Kechris, Katerina“…In addition, we applied the methods to both microRNA (miRNA) and messenger RNA (mRNA) sequencing datasets from a recombinant inbred mouse panel. …”
Publicado 2017
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