“…Quantification of interleukin (IL)-2, interferon gamma, IL- 4, IL-5, and IL-10 secretion by immunoassays, and of interferon gamma, IL-4 and IL-10 messenger RNA expression by competitive reverse transcriptase polymerase chain reaction after in vitro stimulation of the TCR revealed a similar Th1 cytokine profile in T cells from HIV- infected persons and from controls. …”
Enlace del recurso
Enlace del recurso

“…The cytoplasmic domain is involved in trafficking, localization, and modulation by cytoplasmic second messenger systems but its role in channel assembly and function is poorly understood and little is known about its structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Action potential-driven current transients were recorded from sensory cilia and used to monitor the spike frequency generated by olfactory receptor neurons, which were maintained in their natural position in the sensory epithelium. Both basal and messenger-induced activities, as elicited with forskolin or cyclic nucleotides, were dependent on the presence of mucosal Na+. …”
Enlace del recurso
Enlace del recurso

“…This study used messenger RNA encoding each subunit (alpha, beta, gamma and delta) of the nicotinic acetylcholine (ACh) receptor from mouse BC3H-1 cells and from Torpedo electric organ. …”
Enlace del recurso
Enlace del recurso

“…Nitric oxide (NO) is known to be a potent messenger in the intracellular signal transduction system in many tissues. …”
Enlace del recurso
Enlace del recurso

“…The delay in the appearance of the current is consistent with the idea that the production and accumulation of a second messenger is the rate-limiting step in current activation. …”
Enlace del recurso
Enlace del recurso

“…Cyclic AMP is a ubiquitous second messenger that coordinates diverse cellular functions. …”
Enlace del recurso
Enlace del recurso

“…The mammalian cotransporter may be important in eliminating the products of NO metabolism, particularly in cells that generate vast amounts of this messenger. By cotransporting NO(3) (−) with H(+) the cells would additionally eliminate acid equivalents from activated cells that are metabolizing actively, without added energetic investment and with minimal disruption of the transmembrane potential, inasmuch as the cotransporter is likely electroneutral.…”
Enlace del recurso
Enlace del recurso

“…Hence, the objective of this experiment was to qualitatively and quantitatively assess the integrity of total and messenger RNA extracted from bovine skeletal muscle, subcutaneous adipose tissue and liver stored at 4°C at a range of time points up to 22 days post-mortem. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Conclusion and implications: Bimatoprost lacks effects on the FP receptor but may interact with the FP-altFP receptor heterodimer to induce alterations in second messenger signalling. Hence, FP-altFP complexes may represent the underlying basis of bimatoprost pharmacology.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrate that presumptive interfollicular stem cells, alpha 6(+)/MHCI(- )cells, are enriched in messenger RNAs encoding surface receptors, cell adhesion molecules, extracellular matrix proteins, transcripts encoding members of IFN-alpha family proteins and components of IFN signaling, but contain lower levels of transcripts encoding proteins which take part in energy metabolism, cell cycle, ribosome biosynthesis, splicing, protein translation, degradation, DNA replication, repair, and chromosome remodeling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MicroRNAs (miRNAs) interact in a sequence-specific manner with target messenger RNAs (mRNAs) to induce either cleavage of the message or impede translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multicistronic constructs, in which several proteins are encoded by a single messenger RNA, are commonly used in genetically engineered animals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODOLOGY/PRINCIPAL FINDINGS: To examine miRNA regulatory effect on global gene expression under endogenous condition, we performed pair-wise correlation coefficient analysis on expression levels of 366 miRNAs and 14,174 messenger RNAs (mRNAs) in 90 immortalized lymphoblastoid cell lines, and observed significant correlations between the two species of RNA transcripts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression by binding to target messenger RNAs and by controlling protein production or causing RNA cleavage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In Saccharomyces cerevisiae, it is the second messenger in the Ras/PKA pathway which regulates nutrient sensing, stress responses, growth, cell cycle progression, morphogenesis, and cell wall biosynthesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Only the MSG gene adjacent to the expression site is represented by messenger RNA. Several P. carinii MSG genes have been sequenced, which showed that genes in the family can encode distinct isoforms of MSG. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“….-)) may function as a second messenger or regulator of signal transduction when produced at low concentrations in the proper locations within cells. …”
Enlace del recurso
Enlace del recurso

“…Profiling studies of messenger RNA (mRNA) in these cells additionally demonstrated down-regulation of ten let-7 target genes in the adult cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Late phase formalin behavior scores among 10 inbred mouse strains were correlated with a spinal cord gene expression database constructed using expression arrays. Messenger RNA levels for several genes were highly correlated with the late phase behavioral responses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso