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10821“…Of significance, Ag-PVP nanoparticles (10 nm) caused perturbations in a variety of upstream (toll like receptor 2 [TLR2], nucleotide-binding oligomerization-protein 2 [NOD2], cluster of differentiation [CD]40, CD80, and CD86) and downstream (IL-1 receptor-associated kinase 3 [IRAK3] and matrix metallopeptidase 9 [MMP9]) inflammatory signaling pathways by downregulating their messenger ribonucleic acid (mRNA) gene transcript expressions as induced by C. trachomatis in macrophages. …”
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10822por O'Bryan, Moira K., Clark, Brett J., McLaughlin, Eileen A., D'Sylva, Rebecca J., O'Donnell, Liza, Wilce, Jacqueline A., Sutherland, Jessie, O'Connor, Anne E., Whittle, Belinda, Goodnow, Christopher C., Ormandy, Christopher J., Jamsai, Duangporn“…Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. …”
Publicado 2013
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10823“…In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their partial analogy to a prokaryotic polycistron. …”
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10824por Berends, L M, Fernandez-Twinn, D S, Martin-Gronert, M S, Cripps, R L, Ozanne, S E“…In adult recuperated rats, Akt phosphorylation (P<0.01) and protein levels of Akt-2 (P<0.01) were also reduced. Messenger RNA expression levels of these proteins were not different, indicating a post-transcriptional effect. …”
Publicado 2013
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10825“…Target genes were predicted using a computational approach due to their base-pairing rules between miRNA and messenger RNA target sites. The locations of binding sequences were within the target’s 3′ untranslated regions (UTR), and the conservation of target binding sequences occurred within related genomes. …”
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10826por Starlard-Davenport, Athena, Kutanzi, Kristi, Tryndyak, Volodymyr, Word, Beverly, Lyn-Cook, Beverly“…We demonstrated that transfection of pre-miRNA-29b into less aggressive MCF-7 cells, but not MDA-MB-231 mesenchymal cells, inhibited cell proliferation, decreased DNMT3A and DNMT3B messenger RNA (mRNA), and decreased promoter methylation status of ADAM23 , CCNA1, CCND2, CDH1, CDKN1C, CDKN2A, HIC1, RASSF1, SLIT2, TNFRSF10D, and TP73 tumor-suppressor genes. …”
Publicado 2013
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10827por Santini, Tiziana, Turchi, Luana, Ceccarelli, Giulia, Di Franco, Carmen, Beccari, Elena“…CONCLUSIONS: The DX and SIN strains of B. mycoides display very similar RNA transcription specificity. The ftsZ messenger RNA can be found either as an independent transcript or expressed together with ftsA and ftsQ and, in low amounts, with genes that are specific to peptidoglycan biosynthesis.…”
Publicado 2013
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10828por Sugiyama, Tetsuya, Lee, So Yeon, Horie, Taeko, Oku, Hidehiro, Takai, Shinji, Tanioka, Hidetoshi, Kuriki, Yumi, Kojima, Shota, Ikeda, Tsunehiko“…Protein levels of P2X(7) receptor were significantly increased 1, 2, and 3 days after IOP elevation. The messenger ribonucleic acid expression of the P2X(7) receptor, TNF-α, IL-1β, and IL-6 was significantly upregulated in the retina after IOP elevation, and was suppressed by treatment with OxATP. …”
Publicado 2013
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10829por Voellger, Benjamin, Kirches, Elmar, Wilisch-Neumann, Annette, Weise, Andreas, Tapia-Perez, HJ, Rupa, Rosita, Mawrin, Christian, Firsching, Raimund“…We assessed the ability of resveratrol to kill GH3 cells by an enzyme-linked immunosorbent assay (ELISA) of nucleosome liberation and by DNA degradation (unidimensional gel electrophoresis). Relative messenger RNA (mRNA) expression of survivin, B-cell lymphoma-2 protein (BCL-2) and BCL-2-associated X protein (BAX) normalized to β2 microglobulin was measured using quantitative real-time polymerase chain reaction (qRT-PCR). …”
Publicado 2013
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10830“…We designed two IGF-IIP3 specific DNAzymes (DRz1 and DRz2) that target IGF-IIP3 messenger RNA (mRNA) with the aim of reducing IGF-II expression through promoter 3. …”
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10831por Kraemer, Anne, Barjaktarovic, Zarko, Sarioglu, Hakan, Winkler, Klaudia, Eckardt-Schupp, Friederike, Tapio, Soile, Atkinson, Michael J., Moertl, Simone“…BACKGROUND: microRNAs (miRNAs) are non-coding RNAs that alter the stability and translation efficiency of messenger RNAs. Ionizing radiation (IR) induces rapid and selective changes in miRNA expression. …”
Publicado 2013
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10832por Canaparo, Roberto, Varchi, Greta, Ballestri, Marco, Foglietta, Federica, Sotgiu, Giovanna, Guerrini, Andrea, Francovich, Andrea, Civera, Pierluigi, Frairia, Roberto, Serpe, Loredana“…A statistically significant enhanced mRNA (messenger ribonucleic acid) expression of NRF2 (P<0.001) and a significant downregulation of TIGAR (P<0.05) and MAP3K5 (P<0.05) genes was observed in cells exposed to TPPS-NPs and SWs at 24 hours, along with a statistically significant release of cytochrome c (P<0.01) at 48 hours. …”
Publicado 2013
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10833por Bhar, Anirban, Haubrock, Martin, Mukhopadhyay, Anirban, Maulik, Ujjwal, Bandyopadhyay, Sanghamitra, Wingender, Edgar“…BACKGROUND: Estrogen is a chemical messenger that has an influence on many breast cancers as it helps cells to grow and divide. …”
Publicado 2013
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10834por Zhao, Xiaohong, Li, Zuoqing, He, Benfu, Liu, Juncheng, Li, Suisheng, Zhou, Li, Pan, Cuiling, Yu, Zhe, Xu, Zhe“…RESULTS: Western blotting and reverse transcription-PCR showed that the expression level of Sam68 was markedly higher in NB cell lines than in the immortalized normal epithelial cells at both messenger RNA and protein levels. The MTT assay revealed that Sam68 expression supported proliferation of NB cells. …”
Publicado 2013
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10835por Udvardi, Patrick T, Föhr, Karl J, Henes, Carolin, Liebau, Stefan, Dreyhaupt, Jens, Boeckers, Tobias M, Ludolph, Andrea G“…In rat brains probed 2 months after final atomoxetine exposure, messenger RNA analysis also revealed significantly reduced levels of genes coding for NMDAR subunits in MES and STR. …”
Publicado 2013
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10836por Bracha, Shay, Viall, Austin, Goodall, Cheri, Stang, Bernadette, Ruaux, Craig, Seguin, Bernard, Chappell, Patrick E“…Results indicate that intracellular second messenger signal coupling of 5HTR2A is different between normal and malignant cells, warranting further research to investigate its potential as a novel therapeutic target for canine osteosarcoma.…”
Publicado 2013
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10837por Gadave, Kaustubh S., Panda, Santanu, Singh, Surender, Kalra, Shalini, Malakar, Dhruba, Mohanty, Ashok K., Kaushik, Jai K.“…XOR also produces free radicals serving as second messenger and microbicidal agent. Large variation in the XO activity has been observed among various species. …”
Publicado 2014
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10838por Curran, Jerry, Tang, Lifei, Roof, Steve R., Velmurugan, Sathya, Millard, Ashley, Shonts, Stephen, Wang, Honglan, Santiago, Demetrio, Ahmad, Usama, Perryman, Matthew, Bers, Donald M., Mohler, Peter J., Ziolo, Mark T., Shannon, Thomas R.“…Here, we investigate how the cellular second messenger, nitric oxide, mediates CaMKII activity downstream of the adrenergic signaling cascade and promotes the generation of arrhythmogenic spontaneous Ca(2+) waves in intact cardiomyocytes. …”
Publicado 2014
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10839por GURBUZ, VENHAR, KONAC, ECE, VAROL, NURAY, YILMAZ, AKIN, GUROCAK, SERHAT, MENEVSE, SEVDA, SOZEN, SINAN“…Cytotoxic activity, the activation of phosphorylated (p)-STAT3 protein, caspase (CASP) 3 activity at protein level, vascular endothelial growth factor (VEGF) A, VEGFC, vascular endothelial growth factor receptor 2, STAT3, matrix metalloproteinase-2, myeloid cell leukemia sequence 1 (MCL-1), CASP8 and CASP9 messenger RNA (mRNA) levels were determined. Morphology and apoptosis were confirmed by DAPI staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. …”
Publicado 2014
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10840por Xiong, Tou Cheu, Ronzier, Elsa, Sanchez, Frédéric, Corratgé-Faillie, Claire, Mazars, Christian, Thibaud, Jean-Baptiste“…Calcium (Ca(2+)) is a second messenger involved in many plant signaling processes. …”
Publicado 2014
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