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11501“…Real-time quantitative PCR and Western blotting results suggested that messenger ribonucleic acid and protein expression of alkaline phosphatase, bone sialoprotein, collagen type I, and osteocalcin were all downregulated after treatment with recombinant mouse periostin. …”
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11502por Dongiovanni, Paola, Meroni, Marica, Mancina, Rosellina M., Baselli, Guido, Rametta, Raffaela, Pelusi, Serena, Männistö, Ville, Fracanzani, Anna L., Badiali, Sara, Miele, Luca, Grimaudo, Stefania, Petta, Salvatore, Bugianesi, Elisabetta, Soardo, Giorgio, Fargion, Silvia, Pihlajamäki, Jussi, Romeo, Stefano, Valenti, Luca“…In individuals with obesity, the A allele protecting against steatosis was associated with increased PPP1R3B messenger RNA expression and activation of lipid oxidation and with down‐regulation of pathways related to lipid metabolism, inflammation, and cell cycle. …”
Publicado 2018
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11503por Su, Chongyu, Shi, Kang, Cheng, Xu, Han, Yi, Li, Yunsong, Yu, Daping, Liu, Zhidong“…METHODS: Long noncoding RNA, microRNA, and messenger RNA levels were determined using reverse transcription quantitative polymerase chain reaction. …”
Publicado 2018
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11504por Yasar, Hanzey, Biehl, Alexander, De Rossi, Chiara, Koch, Marcus, Murgia, Xabi, Loretz, Brigitta, Lehr, Claus-Michael“…BACKGROUND: Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. …”
Publicado 2018
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11505por Suda, Takahiro, Tatsumi, Tomohide, Nishio, Akira, Kegasawa, Tadashi, Yoshioka, Teppei, Yamada, Ryoko, Furuta, Kunimaro, Kodama, Takahiro, Shigekawa, Minoru, Hikita, Hayato, Sakamori, Ryotaro, Fukuhara, Takasuke, Matsuura, Yoshiharu, Takehara, Tetsuo“…We analyzed serum CEACAM1 level, NK cell function, and CEACAM1 messenger RNA (mRNA) level in human liver samples. …”
Publicado 2018
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11506“…MATERIALS AND METHODS: Expression patterns of miR-128 and peroxisome proliferator-activated receptor gamma (PPAR-γ) messenger RNA in clinical samples and cells were measured using RT-qPCR assay. …”
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11507por Song, Cheng-Cheng, Hong, Quan, Geng, Xiao-Dong, Wang, Xu, Wang, Shu-Qiang, Cui, Shao-Yuan, Guo, Man-Di, Li, Ou, Cai, Guang-Yan, Chen, Xiang-Mei, Wu, Di“…The patient's total blood RNA was extracted to validate the messenger RNA (mRNA) expression of coenzyme Q(10) monooxygenase 6 (COQ6) and validated it by immunohistochemistry. …”
Publicado 2018
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11508por Kappeler, Berna I. G., Regitano, Luciana C. A., Poleti, Mirele D., Cesar, Aline S. M., Moreira, Gabriel C. M., Gasparin, Gustavo, Coutinho, Luiz L.“…BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotides, highly conserved among species, which modulate gene expression by cleaving messenger RNA target or inhibiting translation. MiRNAs are involved in the regulation of many processes including cell proliferation, differentiation, neurogenesis, angiogenesis, and apoptosis. …”
Publicado 2019
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11509“…When the CD44 gene is expressed, its pre-messenger RNA (mRNA) can be alternatively spliced into mature mRNAs that encode several CD44 isoforms. …”
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11510por Gao, Shenglan, Lin, Ziying, Li, Chunyan, Wang, Yahong, Yang, Lawei, Zou, Bao’an, Chen, Jie, Li, Jianwen, Feng, Dehui, Song, Zeqing, Liu, Gang“…We also observed that downregulation of INS-IGF2 readthrough, transcript variant 1, noncoding RNA reduces insulin-like growth factor 2 messenger RNA expression. Furthermore, INS-IGF2 readthrough, transcript variant 1, noncoding RNA downregulation suppresses non-small-cell lung cancer cell proliferation and migration. …”
Publicado 2019
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11511por Camacho, Luísa, Silva, Camila S., Hanig, Joseph P., Schleimer, Robert P., George, Nysia I., Bowyer, John F.“…Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia. Whole blood messenger RNA (mRNA) and whole blood and serum microRNA (miRNA) transcripts were identified in adult male Sprague-Dawley rats after exposure to toxic AMPH under normothermic conditions, AMPH when it produces pronounced hyperthermia, or environmentally-induced hyperthermia (EIH). mRNA transcripts with large increases in fold-change in treated relative to control rats and very low expression in the control group were a rich source of organ-specific transcripts in blood. …”
Publicado 2019
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11512por Mana, Lulu, Feng, Huili, Dong, Yunfang, Wang, Yahan, Shi, Jing, Tian, Jinzhou, Wang, Pengwen“…Immunohistochemistry, western blot analysis and polymerase chain reaction (PCR) were used to detect the expression of the PI3K/AKT-mTOR signalling pathway–related proteins and messenger RNAs (mRNAs) in hippocampus of APP/PS1 transgenic mice after 3 months of drug administration. …”
Publicado 2019
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11513por Pandey, Sriti, Somal, Anjali, Parmar, Mehtab S., Gupta, Swati, Bharti, Mukesh K., Bhat, Irfan A., Indu, B., Chandra, Vikash, Kumar, G. Sai, Sharma, G. Taru“…Cleavage and blastocyst rates were also higher in roscovitine-treated group. The relative messenger RNA expression of oocyte (GDF9, BMP15, GREM1, EGFR, PTGS2 and HAS2) as well as blastocyst (INF-τ, GLUT1 and POU5F1) competence markers was significantly greater in roscovitine-treated group relative to SF group. …”
Publicado 2018
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11514“…To this end, we utilised a range of molecular tools to characterise a well-defined group of female adults with poorly controlled atopic asthma associated with house dust mite (HDM) allergy, relative to non-asthmatic control subjects. Circulating messenger RNA (mRNA) and microRNA (miRNA) were sequenced and quantified, and a differential expression analysis of the two RNA populations performed to determine how gene expression and regulation varied in the disease state. …”
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11515por Salaheldin, Taher A, Loutfy, Samah A, Ramadan, Marwa A, Youssef, Tareq, Mousa, Shaker A“…Evaluation of the cytotoxic effects showed messenger RNA (mRNA) in β-actin and Bax apoptotic genes, but no expression of mRNA of caspase-3 after 24 hours of cell exposure, suggesting the involvement of an intrinsic apoptotic caspase-independent pathway. …”
Publicado 2019
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11516por Ye, Fei, Tang, Qiong Lan, Ma, Fang, Cai, Lei, Chen, Ming, Ran, Xiao Xia, Wang, Xiao Yu, Jiang, Xue Feng“…Bioinformatic analyses, including the negative correlation network analyses of circRNAs–microRNAs (miRNAs)–messenger RNAs (mRNAs) and the Cytoscape, were used to delineate the interaction of circRNAs/miRNAs of the entire network. …”
Publicado 2019
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11517por Rutigliano, Grazia, Bräunig, Julia, Del Grande, Claudia, Carnicelli, Vittoria, Masci, Isabella, Merlino, Sergio, Kleinau, Gunnar, Tessieri, Luca, Pardossi, Simone, Paisdzior, Sarah, Dell’Osso, Liliana, Biebermann, Heike, Zucchi, Riccardo“…TAAR1 is stimulated with nanomolar affinity by 3-iodothyronamine (T1AM), an endogenous messenger considered a novel branch of thyroid hormone signaling. …”
Publicado 2019
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11518por Xiao, Ning, Li, Hongli, Shafique, Laiba, Zhao, Shanshan, Su, Xiaoping, Zhang, Yu, Cui, Kuiqing, Liu, Qingyou, Shi, Deshun“…The histological hematoxylin-and-eosin (H&E) staining results indicated that eumelanin amounts were absent in hair follicles of MC1R-knockout (KO) rabbits, when compared with that of donor BR. In addition, the messenger RNA (mRNA) levels of some key downstream genes in the MC1R pathway were all downregulated in MC1R-KO rabbits compared with BR and YR. …”
Publicado 2019
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11519por de Jong, Joep J., Liu, Yang, Robertson, A. Gordon, Seiler, Roland, Groeneveld, Clarice S., van der Heijden, Michiel S., Wright, Jonathan L., Douglas, James, Dall’Era, Marc, Crabb, Simon J., van Rhijn, Bas W. G., van Kessel, Kim E. M., Davicioni, Elai, Castro, Mauro A. A., Lotan, Yair, Zwarthoff, Ellen C., Black, Peter C., Boormans, Joost L., Gibb, Ewan A.“…While MIBC subtyping has primarily been based on messenger RNA (mRNA), long non-coding RNAs (lncRNAs) may provide additional resolution. …”
Publicado 2019
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11520por Li, Ting, Guo, Hanqing, Li, Hong, Jiang, Yanzhi, Zhuang, Kun, Lei, Chao, Wu, Jian, Zhou, Haining, Zhu, Ruixue, Zhao, Xiaodi, Lu, Yuanyuan, Shi, Chongkai, Nie, Yongzhan, Wu, Kaichun, Yuan, Zuyi, Fan, Dai-Ming, Shi, Yongquan“…METHODS: We performed microRNA (miRNA) and messenger RNA (mRNA) profiling using microarray in cells treated with bile acids. …”
Publicado 2019
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