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11621por Nußbaum, Sarah Marie, Krabbe, Julia, Böll, Svenja, Babendreyer, Aaron, Martin, Christian“…Furthermore, the preparation of PCLS seems to influence messenger ribonucleic acid (mRNA) expression of most target genes. …”
Publicado 2022
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11622por Magnus, Maria C, Håberg, Siri E, Carlsen, Ellen Ø, Kwong, Jeffrey C, Buchan, Sarah A, Fell, Deshayne B“…METHODS: We compared the relative effectiveness of messenger RNA (mRNA) COVID-19 vaccines according to whether women received both doses while pregnant (n = 7412), 1 dose while pregnant (n = 3538), both doses while postpartum (n = 1856), or both doses while neither pregnant nor postpartum (n = 6687). …”
Publicado 2022
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11623por Kostaki, Antigone, Wacker, James W., Safarika, Asimina, Solomonidi, Nicky, Katsaros, Konstantinos, Giannikopoulos, George, Koutelidakis, Ioannis M., Hogan, Catherine A., Uhle, Florian, Liesenfeld, Oliver, Sweeney, Timothy E., Giamarellos-Bourboulis, Evangelos J.“…We prospectively validated a 29–messenger RNA host response classifier for predicting severity in these patients. …”
Publicado 2022
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11624por Han, Mingxiao, Chen, Zhihao, He, Ping, Li, Ziyuan, Chen, Qi, Tong, Zelei, Wang, Min, Du, Hong, Zhang, Haifang“…Furthermore, based on the data of Gene Expression Omnibus, the expression profiles of micro RNAs (miRNAs) and messenger RNAs (mRNAs) in the serum of 44 sepsis patients caused by K. pneumoniae infection were analyzed, and 11 differently expressed miRNAs and 8 DEmRNAs associated with the membrane function were found. …”
Publicado 2022
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11625por Shiga, Hisashi, Kakuta, Yoichi, An, Kumiko, Abe, Yuko, Fujimaki, Shinichi, Shimoyama, Yusuke, Naito, Takeo, Moroi, Rintaro, Kuroha, Masatake, Khor, Seik‐Soon, Kawai, Yosuke, Tokunaga, Katsushi, Kinouchi, Yoshitaka, Masamune, Atsushi“…We prospectively analyzed antibody titers of IBD patients in Asia induced by two‐dose and additional dose of messengerRNA COVID‐19 vaccine. METHODS: After measuring high‐affinity antibody titers, factors associated with antibody titers were identified by multiple regression analyses using the following covariates: sex, age (≥60 or <60 years), disease type (Crohn's disease or ulcerative colitis), vaccine type (BNT162b2 or mRNA‐1273), time from second/third vaccination, molecular‐targeted agent (anti‐tumor necrosis factor [TNF] agents, ustekinumab, vedolizumab, tofacitinib, or no molecular‐targeted agents), thiopurine, steroid, and 5‐aminosalicylic acid. …”
Publicado 2022
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11626“…However, the role of MACF1 in targeting the competing endogenous RNA (ceRNA) network to regulate osteoblast differentiation remains poorly understood. Here, we profiled messenger RNA (mRNA), microRNA (miRNA), and long ncRNA (lncRNA) expression in MACF1 knockdown MC3TC‑E1 pre‑osteoblast cells. …”
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11627por Ailsworth, Samuel M., Keshavarz, Behnam, Richards, Nathan E., Workman, Lisa J., Murphy, Deborah D., Nelson, Michael R., Platts-Mills, Thomas A.E., Wilson, Jeffrey M.“…BACKGROUND: BNT162b2 (Pfizer/BioNTech, Comirnaty) and mRNA-1273 (Moderna, Spikevax) are messenger RNA (mRNA) vaccines that elicit antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (S-RBD) and have been approved by the US Food and Drug Administration to combat the coronavirus disease 2019 (COVID-19) pandemic. …”
Publicado 2023
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11628por Chuleerarux, Nipat, Manothummetha, Kasama, Moonla, Chatphatai, Sanguankeo, Anawin, Kates, Olivia S., Hirankarn, Nattiya, Phongkhun, Kasidis, Thanakitcharu, Jaedvara, Leksuwankun, Surachai, Meejun, Tanaporn, Thongkam, Achitpol, Mongkolkaew, Thanuthong, Dioverti, M. Veronica, Torvorapanit, Pattama, Langsiri, Nattapong, Worasilchai, Navaporn, Plongla, Rongpong, Chindamporn, Ariya, Gopinath, Shilpa, Nissaisorakarn, Pitchaphon, Thaniyavarn, Tany, Nematollahi, Saman, Permpalung, Nitipong“…The average rate (range) of positive functional T-lymphocyte response was 44.2% (34.2%-48.5%) after 2 doses of messenger RNA (mRNA) COVID-19 vaccines. The average antispike antibody response rates (range) were 42.7% (20.8%-88.5%) and 78.2% (55.8%-94.2%) after 1 and 2 doses of mRNA COVID-19 vaccines, respectively. …”
Publicado 2022
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11629por Zhou, Chenxing, Liang, Tuo, Jiang, Jie, Zhang, Zide, Chen, Jiarui, Chen, Tianyou, Chen, Liyi, Sun, Xuhua, Huang, ShengSheng, Zhu, Jichong, Wu, Shaofeng, Zhan, Xinli, Liu, Chong“…To construct a clinical diagnostic model, this study identified the micro RNA-messenger RNA (miRNA-mRNA) interaction network and immune cell infiltration-related hub genes associated with AS. …”
Publicado 2022
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11630por Morales-Núñez, José Javier, Muñoz-Valle, José Francisco, Machado-Sulbarán, Andrea Carolina, Díaz-Pérez, Saúl Alberto, Torres-Hernández, Paola Carolina, Panduro-Espinoza, Beatriz Verónica, Gallegos-Díaz de Leon, Jonathan Adrián, Munguía-Ramirez, Carlos David, Hernández-Bello, Jorge“…This study aimed to compare reactogenicity and NAbs generated by three different COVID-19 vaccine platforms in individuals with and without prior COVID-19. 336 individuals vaccinated (112 with CoronaVac [inactivated virus], 112 with BNT162b2 [messenger RNA], and 112 with Ad5-nCoV [non-replicating viral vector]) were included. …”
Publicado 2022
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11631“…Phospholipids, particularly phosphatidic acid (PA) that functions as a second messenger, play crucial and differential roles in autophagosome formation; however, the underlying mechanism remains largely unknown. …”
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11632por Guo, Keke, Wang, Lusheng, Zhong, Yulan, Gao, Shuang, Jing, Rongrong, Ye, Jiabin, Zhang, Kaini, Fu, Mengli, Hu, Zhenlin, Zhao, Wengang, Xu, Nuo“…In addition, the level of FGF18 messenger ribonucleic acid (mRNA) in the dorsal skin was measured on days 15 and 18 by quantitative real-time polymerase chain reaction (qRT-PCR), while the level of FGF18 protein was measured by western blot and immunofluorescence staining. …”
Publicado 2022
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11633por Wakai, Haruki, Abe, Natsumi, Tokuda, Touno, Yamanaka, Rika, Ebihara, Satoshi, Izumaru, Kensuke, Ishii, Daisuke, Hyodo, Toru, Yoshida, Kazunari“…METHODS: Baseline characteristics and anti-spike protein antibody titers (Roche) over 90 days after administration of the BNT162b2 messenger RNA vaccine were investigated in dialysis patients. …”
Publicado 2022
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11634por Garcia-Dominguez, Dario, Henry, Carole, Ma, LingZhi, Jani, Hardik, Amato, Nicholas J., Manning, Taylor, Freyn, Alec, Davis, Heather, Hsiao, Chiaowen Joyce, Li, Mengying, Koch, Hillary, Elbashir, Sayda, DiPiazza, Anthony, Carfi, Andrea, Edwards, Darin, Bahl, Kapil“…Here, the dosing interval for mRNA-1273, a messenger RNA based SARS-CoV-2 vaccine administered on a 2-dose primary schedule with 4 weeks between doses, was evaluated in mice by varying the dose interval between 1 and 8 weeks and examining immune responses through 24 weeks after dose 2. …”
Publicado 2022
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11635por Jiang, Jieyun, Turpin, Courtney, Qiu, Guofang (Shirley), Xu, Mei, Lee, Eun, Hinds, Terry D., Peterson, Martha L., Spear, Brett T.“…Analysis of data from the Cancer Genome Atlas and Clinical Proteomic Tumor Consortium indicated that ZHX2 messenger RNA and protein levels were significantly higher in patients with HCC and associated with clinical pathological parameters. …”
Publicado 2022
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11636por Cabral, Pablo D., Silva, Guillermo B., Baigorria, Sandra T., Juncos, Luis I., Ajayi, Ebenezer I. O., García, Néstor H.“…Since cyclic adenosine monophosphate (cAMP) is a major messenger for the 8-iso-PGF2α signaling cascade, and NO inhibits J(Cl) by decreasing cAMP bioavailability, we measured 8-iso-PGF2α–stimulated cAMP in the presence of sodium nitroprusside (SNP). …”
Publicado 2022
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11637por Dong, Huimin, Zhao, Lu, Sun, Hengchang, Shang, Mei, Lv, Gang, Yu, Xinbing, Hu, Bo, Huang, Yan“…In cell models, compared with the model in which LX-2 cells were incubated with HBV-positive sera (HBV group), transcripts of alpha-smooth muscle actin and types I and III collagen were significantly elevated in the models of LX-2 cells treated with CsTPs and HBV-positive sera (CsTP+HBV group), while the messenger RNA levels of tumour necrosis factor-α, interleukin (IL)-1β and IL-6 in the CsTP+HBV group were clearly lower. …”
Publicado 2022
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11638por Shi, Yanlong, Wang, Yizhu, Yang, Rui, Zhang, Wenning, Zhang, Yu, Feng, Kun, Lv, Qingpeng, Niu, Kaiyi, Chen, Jiping, Li, Li, Zhang, Yewei“…In addition, the five-gene messenger RNA (mRNA) and protein expression were overexpressed in HCC cells and tissues. …”
Publicado 2022
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11639por Li, Ding, Fan, Xinxin, Zuo, Lihua, Wu, Xuan, Wu, Yingxi, Zhang, Yuanyuan, Zou, Fanmei, Sun, Zhi, Zhang, Wenzhou“…METHODS: The clinical information and corresponding messenger RNA (mRNA)/lncRNA expression profiles were obtained from The Cancer Genome Atlas (TCGA) database, and 502 RAS-related lncRNAs were identified by Pearson correlation analysis. …”
Publicado 2022
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11640por Deng, Xiao-Dong, Ke, Jian-Lin, Chen, Tai-Yu, Gao, Qin, Zhao, Zhuo-Lin, Zhang, Wei, Liu, Huan, Xiang, Ming-Liang, Wang, Li-Zhen, Ma, Ying, Liu, Yun“…The expression levels of ERCC1 messenger RNA (mRNA) in peripheral blood mononuclear cells and its protein in plasma were detected by quantitative real-time PCR (qPCR) and enzyme-linked immunosorbent assay (ELISA), respectively. …”
Publicado 2023
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