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12141por Mata, Alberto Ramírez, Pacheco, César Millán, Cruz Pérez, José F., Sáenz, Martha Minjárez, Baca, Beatriz E.“…BACKGROUND: The cyclic-di-GMP (c-di-GMP) second messenger exemplifies a signaling system that regulates many bacterial behaviors of key importance; among them, c-di-GMP controls the transition between motile and sessile life-styles in bacteria. …”
Publicado 2018
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12142por Abu-Halima, Masood, Kahraman, Mustafa, Henn, Dominic, Rädle-Hurst, Tanja, Keller, Andreas, Abdul-Khaliq, Hashim, Meese, Eckart“…While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression changes of circulating miRNAs and messenger RNAs (mRNA) in monogenic constitutional anomalies affecting several organ systems, like Marfan syndrome (MFS). …”
Publicado 2018
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12143Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosispor Luong, Vu Huy, Chino, Takenao, Oyama, Noritaka, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Niwa, Shin-ichiro, Biswas, Tanima, Hamasaki, Akiyuki, Fujita, Mikako, Okamoto, Yoshinari, Otsuka, Masami, Ihn, Hironobu, Hasegawa, Minoru“…HPH-15 treatment resulted in decreased messenger RNA (mRNA) expression of the M2 macrophage markers arginase 1 and Ym-1 in the skin, whereas it inversely augmented expression of Friend leukemia integration 1 and Krüppel-like factor 5 mRNAs, the transcription factors that repress collagen synthesis. …”
Publicado 2018
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12144por Roberts, Maxine J., Broome, Rebecca E., Kent, Toby C., Charlton, Steven J., Rosethorne, Elizabeth M.“…This highlights the importance of monitoring the kinetics and localisation of intracellular signals, as well as multiple pathways when profiling novel compounds, as population second messenger assays may not always predict phenotypic outcomes. …”
Publicado 2018
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12145por Sanders, Jessica R., Ashley, Bethany, Moon, Anna, Woolley, Thomas E., Swann, Karl“…It is widely accepted that these Ca(2+) oscillations are initiated by a sperm derived phospholipase C isoform, PLCζ that hydrolyses its substrate PIP(2) to produce the Ca(2+) releasing messenger InsP(3). However, it is not clear whether PLCζ induced InsP(3) formation is periodic or monotonic, and whether the PIP(2) source for generating InsP(3) from PLCζ is in the plasma membrane or the cytoplasm. …”
Publicado 2018
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12146“…A key feature of the UPR is the upregulation of ZmbZIP60 and the splicing of its messenger RNA. We conducted an association analysis of a recombinant inbred line (RIL) derived from a cross of a tropical founder line, CML52 with a standard temperate line, B73. …”
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12147por Sun, Yuanyuan, Guo, Dadong, Liu, Bin, Yin, Xuewei, Wei, Huixia, Tang, Kai, Bi, Hongsheng“…MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate messenger RNA (mRNA) expression. It is predicted that rno-miR-30b-5p can regulate the expressions of interleukin-10 (IL-10) and Toll-like receptor 4 (TLR4). …”
Publicado 2018
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12148por Mapanga, Witness, Girdler-Brown, Brendan, Feresu, Shingairai A., Chipato, Tsungai, Singh, Elvira“…The main cervical cancer screening methods described for HIV-seropositive women are HPV deoxyribonucleic acid/messenger RNA (DNA/mRNA) testing (n = 16, 64.0%), visual inspection with acetic acid (VIA) (n = 13, 52.0%) and Pap smear (n = 11, 44.0%). …”
Publicado 2018
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12149por Tornai, David, Furi, Istvan, Shen, Zu T., Sigalov, Alexander B., Coban, Sahin, Szabo, Gyongyi“…A 5‐week alcohol feeding with the Lieber‐DeCarli diet in mice resulted in increased serum alanine aminotransferase (ALT), liver steatosis, and increased proinflammatory cytokines in the liver. TREM‐1 messenger RNA (mRNA) expression was significantly increased in alcohol‐fed mice, and TREM‐1 inhibitors significantly reduced this increase. …”
Publicado 2018
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12150por Liu, Runping, Ahluwalia, Vishwadeep, Kang, Jason D., Ghosh, Siddhartha S., Zhou, Huiping, Li, Yunzhou, Zhao, Derrick, Gurley, Emily, Li, Xiaojiaoyang, White, Melanie B., Fagan, Andrew, Lippman, H. Robert, Wade, James B., Hylemon, Phillip B., Bajaj, Jasmohan S.“…For the animal study, young (10‐12 weeks) and old (1.5 years) C57BL/6 mice were given either CCl(4) gavage to develop cirrhosis or a vehicle control and were followed for 12 weeks. Cortical messenger RNA (mRNA) expression of inflammatory mediators (interleukin [IL]‐6, IL‐1β, transforming growth factor β [TGF‐β], and monocyte chemoattractant protein 1), sirtuin‐1, and gamma‐aminobutyric acid (GABA)‐ergic synaptic plasticity (neuroligin‐2 [NLG2], discs large homolog 4 [DLG4], GABA receptor, subunit gamma 1/subunit B1 [GABRG1/B1]) were analyzed and compared between younger/older control and cirrhotic mice. …”
Publicado 2018
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12151por Velez-Irizarry, Deborah, Casiro, Sebastian, Daza, Kaitlyn R., Bates, Ronald O., Raney, Nancy E., Steibel, Juan P., Ernst, Catherine W.“…In this study, we perform eQTL analyses to identify potential candidate genes and molecular markers regulating growth and meat quality traits in pigs. RESULTS: Messenger RNA transcripts obtained with RNA-seq of longissimus dorsi muscle from 168 F2 animals from a Duroc x Pietrain pig resource population were used to estimate gene expression variation subject to genetic control by mapping eQTL. …”
Publicado 2019
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12152Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcomapor Jia, Jinpeng, Yin, Pei, Zhang, Xingpeng, Yang, Fei, Song, Ge, Bi, Wenzhi, Han, Gang, Xu, Meng, Wang, Wei, Zheng, Xiaoque“…Tumor tissues and para-carcinoma normal tissues were collected from 64 STS patients. The messenger ribonucleic acid (mRNA) expression levels of p16 and nm23-H1 in the tissues were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the protein expression levels of p16 and nm23-H1 in tissues were detected using immunohistochemistry. …”
Publicado 2019
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12153por Dick, Alec L. W., Khermesh, Khen, Paul, Evan, Stamp, Fabian, Levanon, Erez Y., Chen, Alon“…Editing within the Htr2c transcript and relative abundance of Htr2c messenger RNA (mRNA)variants were also observed within the BLA of susceptible mice 2 days following CSDS. …”
Publicado 2019
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12154por Feng, Dexiang, Wang, Xiaodan, Li, Erchao, Bu, Xianyong, Qiao, Fang, Qin, Jianguang, Chen, Liqiao“…The hepatopancreatic cytochrome P450 2 and 4 (CYP2, CYP4), fatty acid binding proteins 3 and 10 (FABP3, FABP10) and intracellular lipolytic enzyme (IL) Messenger Ribonucleic Acid (mRNA) levels in the PCB-only group were significantly higher than those in the control group, and dietary 240000 IU/kg vitamin A supplementation decreased hepatopancreatic CYP4, FABP3, FABP10 and IL enzyme mRNA level. …”
Publicado 2019
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12155por Jin, Song, Xiang, Peng, Liu, Jie, Yang, Yang, Hu, Shuai, Sheng, Jindong, He, Qun, Yu, Wei, Han, Wenke, Jin, Jie, Peng, Jing“…The quantitative polymerase chain reaction was used for assaying the level of messenger RNA expression of CCL5. CCL5 in the conditioned media was detected by the enzyme‐linked immunosorbent assay. …”
Publicado 2019
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12156por Li, Ming, Xie, Zhongyu, Cai, Zhaopeng, Su, Fang, Zheng, Guan, Li, Jinteng, Wang, Shan, Cen, Shuizhong, Liu, Wenjie, Tang, Su’an, Ye, Guiwen, Li, Zhaofeng, Mi, Rujia, Pan, Yiqian, Wang, Peng, Wu, Yanfeng, Shen, Huiyong“…BACKGROUND: The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating the function of monocytes and to clarify the mechanisms by which MSCs exert immunoregulatory effects on monocytes. …”
Publicado 2019
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12157por Kotsafti, Andromachi, D'Incà, Renata, Scarpa, Melania, Fassan, Matteo, Angriman, Imerio, Mescoli, Claudia, Bortoli, Nicolò, Brun, Paola, Bardini, Romeo, Rugge, Massimo, Savarino, Edoardo, Zingone, Fabiana, Castoro, Carlo, Castagliuolo, Ignazio, Scarpa, Marco“…Immunohistochemistry and real time polymerase chain reaction for CD4, CD69, CD107, and CD8β messenger RNA (mRNA) expression and flow cytometry for epithelial cells expressing CD80 or HLA avidin-biotin complex were performed. …”
Publicado 2019
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12158“…Real-time quantitative polymerase chain reaction (RT-qPCR) was used to measure messenger RNA expression of Toll-like receptor 7 (TLR7), myeloid differentiation primary response 88 (MyD88), and nuclear factor-kappa B (NF-κB) p65 in the TLR7 signaling pathway and virus replication in the lungs. …”
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12159por Briggs, Benjamin J, Santos, Yale, Ramesh, Akshaya, Grabherr, Manfred, Achari, Asmeeta, Yu, Guixia, Miller, Steve, Miller, Steve, Federman, Scot, Arevalo, Shaun, Sample, Hannah, Zorn, Kelsey, Harriman, Kathleen, Messenger, Sharon, Domingue, Samuel, Dominguez, Samuel, Glaser, Carol, Wadford, Debra, Messacar, Kevin, Messacar, Kevin, Wilson, Michael, Chiu, Charles, Chiu, CharlesEnlace del recurso
Publicado 2019
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12160por Castanheira, Mariana, Doyle, Timothy B, Hubler, Cory, Healy, Matthew, Smith, Caitlin J, Mendes, Rodrigo E“…We evaluated resistance mechanisms against these agents among 109 PSA isolates using WGS and messenger (m)RNA-sequencing. METHODS: PSA clinical isolates from Europe (n = 62), Asia-Pacific (n = 22), and Latin America (n = 25) in 2017 were susceptibility tested using reference methods and 109 were randomly selected for WGS and total mRNA-sequencing. …”
Publicado 2019
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